Impact of Polyphenols on Inflammatory and Oxidative Stress Factors in Diabetes Mellitus: Nutritional Antioxidants and Their Application in Improving Antidiabetic Therapy

Krawczyk, Michal; Burzynska-Pedziwiatr, Izabela; Wozniak, Lucyna A.; Bukowiecka-Matusiak, Malgorzata

doi:10.3390/biom13091402

Cited by 18 publications

(10 citation statements)

References 188 publications

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“…For example, dapagliflozin protects hyperglycemia-induced cardiomyocytes damage through inhibiting NADPH oxidase-mediated oxidative stress ( Xing et al, 2021 ). Notably, polyphenols have been considered to have the potential to treat diabetes due to their strong antioxidant ability ( Krawczyk et al, 2023 ). Rutin and quercetin have been found to enhance glucose uptake by decreasing oxidative stress in L6 myotubes induced by tertiary butyl hydrogen peroxide ( Dhanya et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

N-p-coumaroyloctopamine ameliorates hepatic glucose metabolism and oxidative stress involved in a PI3K/AKT/GSK3β pathway

Huang,

Zhang,

et al. 2024

Front. Pharmacol.

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Type 2 diabetes mellitus is regarded as a chronic metabolic disease characterized by hyperglycemia. Long-term hyperglycemia may result in oxidative stress, damage pancreatic β-cell function and induce insulin resistance. Herein we explored the anti-hypoglycemic effects and mechanisms of action of N-p-coumaroyloctopamine (N-p-CO) in vitro and in vivo. N-p-CO exhibited high antioxidant activity, as indicated by the increased activity of SOD, GSH and GSH-Px in HL-7702 cells induced by both high glucose (HG) and palmitic acid (PA). N-p-CO treatment significantly augmented glucose uptake and glycogen synthesis in HG/PA-treated HL-7702 cells. Moreover, administration of N-p-CO in diabetic mice induced by both high-fat diet (HFD) and streptozotocin (STZ) not only significantly increased the antioxidant levels of GSH-PX, SOD and GSH, but also dramatically alleviated hyperglycemia and hepatic glucose metabolism in a dose-dependent manner. More importantly, N-p-CO upregulated the expressions of PI3K, AKT and GSK3β proteins in both HG/PA-induced HL-7702 cells and HFD/STZ-induced mice. These findings clearly suggest that N-p-CO exerts anti-hypoglycemic and anti-oxidant effects, most probably via the regulation of a PI3K/AKT/GSK3β signaling pathway. Thus, N-p-CO may have high potentials as a new candidate for the prevention and treatment of diabetes.

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Section: Discussionmentioning

confidence: 99%

N-p-coumaroyloctopamine ameliorates hepatic glucose metabolism and oxidative stress involved in a PI3K/AKT/GSK3β pathway

Huang,

Zhang,

et al. 2024

Front. Pharmacol.

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“…Polyphenols exert promising antioxidant properties, protecting cells against oxidative damage and chronic ailments 22 . In addition, they possess anti-inflammatory properties via regulating inflammatory pathways and enhance cardiovascular well-being by improving blood vessel functionality and reducing LDL cholesterol levels 23 . Additionally, they possess neuroprotective properties, which may aid in treating neurodegenerative disorders 12 , 24 .…”

Section: Introductionmentioning

confidence: 99%

Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

Mamun,

Shao,

Geng

et al. 2024

Int. J. Biol. Sci.

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Polyphenolic compounds have shown promising neuroprotective properties, making them a valuable resource for identifying prospective drug candidates to treat several neurological disorders (NDs). Numerous studies have reported that polyphenols can disrupt the nuclear factor kappa B(NF-κB) pathway by inhibiting the phosphorylation or ubiquitination of signaling molecules, which further prevents the degradation of IκB. Additionally, they prevent NF-κB translocation to the nucleus and pro-inflammatory cytokine production. Polyphenols such as curcumin, resveratrol, and pterostilbene had significant inhibitory effects on NF-κB, making them promising candidates for treating NDs. Recent experimental findings suggest that polyphenols possess a wide range of pharmacological properties. Notably, much attention has been directed towards their potential therapeutic effects in NDs such as Alzheimer's disease (AD), Parkinson's disease (PD), cerebral ischemia, anxiety, depression, autism, and spinal cord injury (SCI). Much preclinical data supporting the neurotherapeutic benefits of polyphenols has been developed. Nevertheless, this study has described the significance of polyphenols as potential neurotherapeutic agents, specifically emphasizing their impact on the NF-κB pathway. This article offers a comprehensive analysis of the involvement of polyphenols in NDs, including both preclinical and clinical perspectives.

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“…Polyphenols, for instance, are one of the chemical molecules that have captured the scienti c community's attention in search for novel therapeutic agents to treat in ammatory illnesses. Secondary plant metabolites such as phenolic acids, avonoids, catechins, tannins, lignans, stilbenes, and anthocyanidins have been shown to have key chemopreventive and protective activities for health maintenance [24][25][26]. Long-term consumption of polyphenol-rich diets offers protection against the development of a variety of chronic diseases, including neurodegenerative, cardiovascular, cancer, diabetes, in ammatory disorders, infectious diseases, and anemia, according to preclinical and clinical evidence [27,28].…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology and an in silico-based study to identify proinflammatory pathways and promising bioactive polyphenols for the treatment of sickle cell anemia

Pérez,

Lázaro,

Puentes

et al. 2024

Preprint

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Sickle cell anemia (SCA) is a disease transmitted as an autosomal recessive Mendelian trait. It causes symptoms that worsen with age, such as acute and chronic pain, chest syndrome, pulmonary hypertension, stroke, kidney disease, and vaso-occlusive crises (VOCs), which are the leading cause of hospitalization and premature death. Although there are existing treatments to manage it, side effects related to VOCs such as patients’ inflammatory state requires the review of options for its control. In this sense, the study of polyphenols represents a potential alternative for the treatment of ACS due to their widely reported anti-inflammatory capacities. This research identified hub genes associated with inflammatory processes in SCA by extracting differentially expressed genes (DEGs) in a GEO dataset collection. Then, polyphenols with anti-inflammatory activity were selected from natural product databases, subsequently, molecular docking was performed with the polyphenols and the key protein derived from the selected hub genes. Finally, molecular dynamics were performed on the promising complexes. The comparative analysis allowed us to find 10 genes associated with proinflammatory pathways in SCA (MX1, FIT1, IFIT3, STAT1, ISG15, GBP1, OAS1, OAS2, OAS3, and RSAD); among them, STAT1 was selected as a central gene by regulating the expression of the rest. Docking and dynamics studies showed good binding energies among STAT1 and the fifteen polyphenolic extracted compounds, with quercetin, diosmetin, and fisetin showing the lowest binding energies. These flavonoids have been described in the past as compounds having anti-inflammatory and antioxidant features, as well as possible alternatives for SCA treatment.

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Impact of Polyphenols on Inflammatory and Oxidative Stress Factors in Diabetes Mellitus: Nutritional Antioxidants and Their Application in Improving Antidiabetic Therapy

Cited by 18 publications

References 188 publications

N-p-coumaroyloctopamine ameliorates hepatic glucose metabolism and oxidative stress involved in a PI3K/AKT/GSK3β pathway

N-p-coumaroyloctopamine ameliorates hepatic glucose metabolism and oxidative stress involved in a PI3K/AKT/GSK3β pathway

Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

Network pharmacology and an in silico-based study to identify proinflammatory pathways and promising bioactive polyphenols for the treatment of sickle cell anemia

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