Impact of polyethylene glycol as additive on the formation and extraction behavior of ionic‐liquid based aqueous two‐phase system

Vahidnia, Mohammad H.; Pazuki, Gholamreza; Abdolrahimi, Shiva

doi:10.1002/aic.15035

Cited by 17 publications

(12 citation statements)

References 38 publications

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“…The partitioning behavior of biomolecules can be improved by introducing some additives such as neutral salts, polymers, surfactants, and hydrophilic solvents. , Recently, a novel approach toward improvement in biomolecules partitioning by the addition of nanoparticles to ATPS was proposed …”

Section: Introductionmentioning

confidence: 99%

Effect of Nanoparticle Additives on Partitioning of Cephalexin in Aqueous Two-Phase Systems Containing Poly(ethylene glycol) and Organic Salts

2016

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In this work, the ability of four nanoparticles including Al2O3, TiO2, graphene, and graphene oxide (GO) as additives for extraction of cephalexin in aqueous two-phase systems composed of polyethylene glycol (PEG) and three sodium-based organic salts was investigated. For this purpose, phase diagrams and the liquid–liquid equilibrium (LLE) data for the {PEG 6000 + sodium citrate, sodium tartrate, sodium succinate + H2O} and partition coefficient for cephalexin were determined. The addition of 0.001 wt % graphene oxide increased the partition coefficient by 9% for the {PEG + sodium citrate + water} system, while other nanoparticles had no effect or decreased the partition coefficient. To investigate the effect of GO concentration on the partition coefficient, various concentrations ranging from 0.005 to 0.04 wt % was examined. It is observed that at a GO concentration equal to 0.01 wt %, the maximum partition coefficient improvement is achievable to be 59%. The highest partition coefficient 5.74 was obtained for the system {PEG6000 19 wt %, sodium citrate 10 wt %, and GO 0.01 wt %}. It can be concluded that a trace amount of nanoparticles can change the partition coefficient either by increasing or decreasing. It seems that the concentration of nanoparticle also has a significant effect on the partition coefficient.

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Section: Introductionmentioning

confidence: 99%

Effect of Nanoparticle Additives on Partitioning of Cephalexin in Aqueous Two-Phase Systems Containing Poly(ethylene glycol) and Organic Salts

2016

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“…A common standard RSM design is central composite design (CCD). This was used as a base of this study to investigate the effect of process factors on the viscosity of ketchup (Vahidnia, Pazuki, & Abdolrahimi, 2016).…”

Section: Response Surface Methodologymentioning

confidence: 99%

Effect of pressure homogenization and modified starch on the viscosity of ketchup: Experimental and modeling

Baeghbali

Shahriari

Pazuki

2021

J Food Process Engineering

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The simultaneous determination of the suitable level of homogenization pressure and modified starch is an important issue, which affects the quality of the industrial ketchup. In this study, ketchup was produced at different pressures of homogenization (0, 5, 8, 11, 14, 17, and 20 MPa) and different weight percentages of modified starch (0, 0.1, 0.4, 0.7, and 1 g/100 g). The viscosity of ketchup was measured at different temperatures. The results showed that the selected ketchup, which contains 1 g/100 g of modified starch and homogenized at a temperature of 25°C and a pressure of 14 MPa, has the optimum viscosity and consistency. After that, to evaluate the effect of homogenization on the physical properties of selected ketchup, additional tests such as the dynamic dispersion scale, the optical microscopy and the Fourier transform infrared spectrophotometer were done. The results indicated a smaller particle size, a more uniform, and a continuous structure of selected ketchup compared with the control sample. Consequently, several different rheological models were investigated for evaluating the rheological behavior of selected ketchup. The statistical measures indicated that the Cross model could predict the rheological behavior of selected ketchup well (R2 = 0.998). Practical Applications Viscosity and syneresis can have strong effects on ketchup quality. Also, reliable rheological data are necessary for designing and optimization of ketchup processing equipment such as pumps, piping, heat exchangers, evaporators, sterilizers, filters, and mixers. In this research, the simultaneous effect of the modified starch and pressure homogenization on the rheological data of ketchup was evaluated. The purpose of this study is to help the ketchup industry by determining the optimum level of homogenization pressure and the optimal dose of modified starch when used simultaneously. Paying attention to this subject is vital for loss prevention in the process and machine depreciation. Furthermore, the rheological behavior which is important during storage, processing, and the transport of ketchup in the industry is determined.

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“…Confinement of enzymes allows their continuous use while they are physically or chemically confined or localised in a certain defined area of the support, maintaining their structural integrity and exhibiting better catalytic activity [63][64][65]. Therefore, the choice of the support and enzyme confinement technique should take into account the nature of the enzyme, namely its biochemical and kinetic properties, the nature and type of the support and the purpose of application [66][67][68][69][70].…”

Section: Types Of Asnase Confinementmentioning

confidence: 99%

Recent Strategies and Applications for l-Asparaginase Confinement

et al. 2020

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l-asparaginase (ASNase, EC 3.5.1.1) is an aminohydrolase enzyme with important uses in the therapeutic/pharmaceutical and food industries. Its main applications are as an anticancer drug, mostly for acute lymphoblastic leukaemia (ALL) treatment, and in acrylamide reduction when starch-rich foods are cooked at temperatures above 100 °C. Its use as a biosensor for asparagine in both industries has also been reported. However, there are certain challenges associated with ASNase applications. Depending on the ASNase source, the major challenges of its pharmaceutical application are the hypersensitivity reactions that it causes in ALL patients and its short half-life and fast plasma clearance in the blood system by native proteases. In addition, ASNase is generally unstable and it is a thermolabile enzyme, which also hinders its application in the food sector. These drawbacks have been overcome by the ASNase confinement in different (nano)materials through distinct techniques, such as physical adsorption, covalent attachment and entrapment. Overall, this review describes the most recent strategies reported for ASNase confinement in numerous (nano)materials, highlighting its improved properties, especially specificity, half-life enhancement and thermal and operational stability improvement, allowing its reuse, increased proteolysis resistance and immunogenicity elimination. The most recent applications of confined ASNase in nanomaterials are reviewed for the first time, simultaneously providing prospects in the described fields of application.

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Impact of polyethylene glycol as additive on the formation and extraction behavior of ionic‐liquid based aqueous two‐phase system

Cited by 17 publications

References 38 publications

Effect of Nanoparticle Additives on Partitioning of Cephalexin in Aqueous Two-Phase Systems Containing Poly(ethylene glycol) and Organic Salts

Effect of Nanoparticle Additives on Partitioning of Cephalexin in Aqueous Two-Phase Systems Containing Poly(ethylene glycol) and Organic Salts

Effect of pressure homogenization and modified starch on the viscosity of ketchup: Experimental and modeling

Recent Strategies and Applications for l-Asparaginase Confinement

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