Impact of Poly (Vinyl Alcohol) on The Thermogelation Property and Drug Release Profile of Ophthalmic Formulations Based on Poloxamer 407

Dewan, Mitali; Adhikari, Arpita; Dutta, Koushik; Chattopadhyay, Dipankar

doi:10.1002/slct.202203528

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…It is widely known that various controlling factors like viscosity, gel strength, structure of pores in gel matrix, dissolution rate of gel in fluid and interaction between drug and gel may affect the drug diffusion rate. 35 Herein, the addition of cellulose increased the viscosity, densified the pore structure and prolonged the swelling time of P-407, thereby slowing down the diffusion rate of ALN from the gel. In PLO&CMC formulation, these changes were the most pronounced, resulting in the minimal rate of ALN release.…”

Section: Resultsmentioning

confidence: 96%

Poloxamer 407 modified collagen/β-tricalcium phosphate scaffold for localized delivery of alendronate

Zhang,

Zhu,

Liang

et al. 2024

J Biomater Appl

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Systemic administration of alendronate is associated with various adverse reactions in clinical settings. To mitigate these side effects, poloxamer 407 (P-407) modified with cellulose was chosen to encapsulate alendronate. This drug-loaded system was then incorporated into a collagen/β-tricalcium phosphate (β-TCP) scaffold to create a localized drug delivery system. Nuclear magnetic resonance spectrum and rheological studies revealed hydrogen bonding between P-407 and cellulose as well as a competitive interaction with water that contributed to the delayed release of alendronate (ALN). Analysis of the degradation kinetics of P-407 and release kinetics of ALN indicated zero-order kinetics for the former and Fickian or quasi-Fickian diffusion for the latter. The addition of cellulose, particularly carboxymethyl cellulose (CMC), inhibited the degradation of P-407 and prolonged the release of ALN. The scaffold’s structure increased the contact area of P-407 with the PBS buffer, thereby, influencing the release rate of ALN. Finally, biocompatibility testing demonstrated that the drug delivery system exhibited favorable cytocompatibility and hemocompatibility. Collectively, these findings suggest that the drug delivery system holds promise for implantation and bone healing applications.

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Section: Resultsmentioning

confidence: 96%

Poloxamer 407 modified collagen/β-tricalcium phosphate scaffold for localized delivery of alendronate

Zhang,

Zhu,

Liang

et al. 2024

J Biomater Appl

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“…Moreover, hydrogel is employed in electrocatalysis, providing a supporting matrix for electrocatalytic materials to enhance various reactions [44,45]. The hydrogel is applied not only in the electrochemical field, but also in various fields such as drug delivery system [46], mechanics [47,48], and environmental fields [49].…”

Section: Introductionmentioning

confidence: 99%

Single-Entity Electrochemistry in the Agarose Hydrogel: Observation of Enhanced Signal Uniformity and Signal-to-Noise Ratio

Park²,

Kwon

2023

Gels

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For the first time, single-entity electrochemistry (SEE) was demonstrated in a hydrogel matrix. SEE involves the investigation of the electrochemical characteristics of individual nanoparticles (NPs) by observing the signal generated when a single NP, suspended in an aqueous solution, collides with an electrode and triggers catalytic reactions. Challenges associated with SEE in electrolyte-containing solutions such as signal variation due to NP aggregation and noise fluctuation caused by convection phenomena can be addressed by employing a hydrogel matrix. The polymeric hydrogel matrix acts as a molecular sieve, effectively filtering out unexpected signals generated by aggregated NPs, resulting in more uniform signal observations compared to the case in a solution. Additionally, the hydrogel environment can reduce the background current fluctuations caused by natural convection and other factors such as impurities, facilitating easier signal analysis. Specifically, we performed SEE of platinum (Pt) NPs for hydrazine oxidation within the agarose hydrogel to observe the electrocatalytic reaction at a single NP level. The consistent porous structure of the agarose hydrogel leads to differential diffusion rates between individual NPs and reactants, resulting in variations in signal magnitude, shape, and frequency. The changes in the signal were analyzed in response to gel concentration variations.

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Influence of Sepiolite on the Rheological Properties of PVA Composite Hydrogels

Jiang,

Wen,

Lin

et al. 2024

ChemistrySelect

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Polyvinyl alcohol (PVA) hydrogel has attracted significant attention in the field of biomedicine, sensors, and other related areas due to their exceptional biocompatibility and interfacial properties. However, conventional single‐component hydrogels often face challenges associated with insufficient mechanical and rheological properties, lacking the structural strength required for practical applications. This study aims to investigate the impact of introducing sepiolite on the rheological behavior of PVA hydrogels. To this end, sepiolite/PVA composite hydrogels were fabricated using a chemical cross‐linking technique. Subsequently, a comprehensive series of rheological experiments was conducted to assess their properties. Experimental results and model comparisons demonstrate that fractional order constitutive equations can accurately describe the rheological behavior of the hybrid hydrogels. With the increase of sepiolite content in the hydrogel, the critical strain does not change significantly, but both the storage modulus and loss modulus of the hydrogel gradually increase. When the sepiolite content reaches 10 wt %, the tensile strength of the composite hydrogel at the yield point jumps to 17.07 kPa, and the toughness increases to 549.69 kJ/m3. This significant improvement in toughness is accompanied by a fracture strain of approximately 4000 %. By adjusting the sepiolite content, different rheological properties can be achieved.

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Impact of Poly (Vinyl Alcohol) on The Thermogelation Property and Drug Release Profile of Ophthalmic Formulations Based on Poloxamer 407

Cited by 5 publications

References 55 publications

Poloxamer 407 modified collagen/β-tricalcium phosphate scaffold for localized delivery of alendronate

Poloxamer 407 modified collagen/β-tricalcium phosphate scaffold for localized delivery of alendronate

Single-Entity Electrochemistry in the Agarose Hydrogel: Observation of Enhanced Signal Uniformity and Signal-to-Noise Ratio

Influence of Sepiolite on the Rheological Properties of PVA Composite Hydrogels

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