Impact of Pneumococcal Conjugate Vaccine on Pediatric Tympanostomy Tube Insertion in Partial Immunized Population

Wang, Mao-Che; Wang, Ying‐Piao; Chu, Chin‐Chou; Tu, Tzong-Yang; Shiao, An‐Suey; Chou, Pesus

doi:10.1155/2015/248678

Cited by 5 publications

(6 citation statements)

References 67 publications

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Section: Tympanostomy Tube Insertionmentioning

confidence: 99%

“…The remaining 5 studies 10,11,13,16,21 were included in the qualitative analysis. In 3 studies, 13,16,21 the rate of tympanostomy tube insertion was significantly decreased in the post-PCV7 period compared with the pre-PCV vaccine period. One study 11 reported a greater reduction in the number of tympanostomy tube insertions in the PCV13 group than in the PCV7 group (HR, 0.76; 95% CI, 0.72-0.80).…”

Section: Tympanostomy Tube Insertionmentioning

confidence: 99%

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Efficacy of Pneumococcal Vaccine on Otitis Media: A Systematic Review and Meta‐Analysis

Wannarong

Ekpatanaparnich

Boonyasiri

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveTo assess the effect of the pneumococcal vaccine (PCV) toward the surgical management and complications of otitis media.Data SourcesMEDLINE, EMBASE, PubMed, Scopus, and clinicaltrial.gov.Review MethodsA systematic search was performed using a combination of keywords and standardized terms about PCV and surgical management or complications of otitis media. Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, studies were screened by 3 independent reviewers. Risk of bias assessment, followed by meta‐analysis in only randomized‐controlled trials was conducted. Vaccine efficacy (VE) and 95% confidence interval (CI) were reported.ResultsOf the 2649 abstracts reviewed, 27 studies were included in the qualitative analysis and were categorized into 6 outcomes: tympanostomy tube insertion, otitis media with effusion (OME), mastoiditis, spontaneous tympanic membrane (TM) perforation, recurrent acute otitis media (AOM), and severe AOM. Fifteen studies were included in the meta‐analysis to evaluate the rate of tympanostomy tube insertion, OME, and recurrent AOM. PCV was significantly more effective in lowering the rate of tympanostomy tube insertion (VE, 22.2%; 95% CI, 14.6‐29.8) and recurrent AOM (VE, 10.06%; 95% CI, 7.46‐12.65) when compared with the control group, with no significant difference in reducing the incidence of OME. The qualitative analysis revealed that PCV had efficacy in preventing severe AOM and spontaneous TM perforation but the effect on mastoiditis remained unclear.ConclusionThe PCV was effective in reducing the rate of tympanostomy tube insertion and the incidence of recurrent AOM with a nonsignificant effect in preventing OME in children.

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Section: Tympanostomy Tube Insertionmentioning

confidence: 99%

Section: Tympanostomy Tube Insertionmentioning

confidence: 99%

Efficacy of Pneumococcal Vaccine on Otitis Media: A Systematic Review and Meta‐Analysis

Wannarong

Ekpatanaparnich

Boonyasiri

et al. 2023

Otolaryngol.--head neck surg.

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“…9,10 Besides antibiotic treatment, the pneumococcal conjugate vaccine (PCV) composed of capsular polysaccharide antigens has been demonstrated to be highly effective in preventing pneumococcal disease and controlling IPDs worldwide, particularly in the developed countries. [11][12][13][14] Moreover, herd immunity, which is believed to be mediated by a reduction in the transmission of pneumococci to susceptible individuals, has been discovered as another benefit of universal PCV7 immunization programs. 14 Three PCVs, including PCV 7, PCV 10, and PCV 13, are currently available on the market, which are immunogenic and protective among children less than 2 years old.…”

Section: Introductionmentioning

confidence: 99%

<p>Investigation of Antibiotic Resistance, Serotype Distribution, and Genetic Characteristics of 164 Invasive <em>Streptococcus pneumoniae</em> from North China Between April 2016 and October 2017</p>

Zhao

Xie

Zhang

et al. 2020

IDR

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Background Streptococcus pneumoniae infections are the major cause of global morbidity and mortality among children and patients aged more than 65 years. This study aimed to investigate the antimicrobial resistance, bacterial serotype distribution, and genetic characteristics of invasive S. pneumoniae from different cities in North China. Materials and Methods A total of 164 invasive S. pneumoniae strains were collected from 8 hospitals in 5 regions of North China between April 2016 and October 2017. Minimum inhibitory concentrations (MICs) were determined using the agar dilution method. Capsular serotypes were identified using the Quellung reaction test. Molecular epidemiology was investigated using multilocus sequence typing. Results S. pneumoniae isolates were highly resistant to macrolides, clindamycin, and tetracycline in all age groups. The overall rate of resistance to penicillin was 56.7%. However, fluoroquinolones and vancomycin maintained excellent antimicrobial activities. The rate of resistance to β-lactam in strains isolated from children aged less than 18 years was significantly higher than that in strains from other age groups. The most prevalent serotypes were 14 (22.6%), 19F (16.5%), non-vaccine types (14.0%), 19A (9.8%), and 23F (9.1%). The coverage for PCV10 and PCV13 was 59.8% and 75.6%, respectively. The vaccine coverage rate was the highest among children aged less than 5 years. The proportion of penicillin-resistant isolates was higher among vaccine-covered strains compared with non-covered strains. S. pneumoniae showed considerable clonal dissemination, and ST876 (28, 17.1%), ST271 (22, 13.4%), ST81 (17, 10.4%) and ST320 (14, 8.5%) were the major STs. Conclusion All the 164 invasive S. pneumoniae isolates demonstrated high resistance to antibiotics. The coverage of S. pneumoniae vaccine was higher in children than in adults.

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“…16 We therefore consider that the dataset used herein is Prophylactic effects of PCV were examined in studies of the 10-valent pneumococcal non-typable Hemophilus influenzae protein D conjugate vaccine (PHiD-CV); most of the studies reported a reduction in the MTTI incidence by PHiD-CV. [17][18][19] Investigations conducted after the introduction of PCVs indicated that both PCV7 [8][9][10][11][12][13][14]20 and the subsequent introduction of PCV13 continued to reduce the incidence of MTTI. [21][22][23] However, most of those etiological studies were conducted based on the use of the whole data with all age groups of children.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies further suggest prophylactic effects on the onset of ROM and the incidence of MTTI caused by complex otitis media (ComOM). [8][9][10][11][12][13][14] However, little information is available about specific age groups who would receive health benefit from the prevention of ComOM that requires MTTI.…”

Section: Introductionmentioning

confidence: 99%

Pneumococcal conjugate vaccines reduce myringotomy with tympanostomy tube insertion in young children in Japan

Ogawa

Kunimoto

Takeno

et al. 2021

Laryngoscope Investig Oto

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Objective: Pneumococcal conjugate vaccines (PCVs) have been reported to reduce the incidence of myringotomy with tympanostomy tube insertion (MTTI) in children.However, little information is available focusing specific ages. We examined the prophylactic efficacy of PCVs on the onset of complex otitis media (ComOM) that requires MTTI.Method: From 2011, the public support for PCV7 started with the usual four-dose schedule and an emergency schedule for 2-to 4-year-old children in Japan. PCV7 was replaced with PCV13 in 2013. We reviewed the nationwide database obtained from the JMDC Claims Database (https://www.jmdc.co.jp/en/) to examine the MTTI incidence during the era before and after PCV introduction (from 2008 to 2010 and from 2011 to 2017, respectively). Subjects were analyzed by stratified age groups (from 0 to 8 years old) and in subdivided groups of 6 months (from 0 to 35 months old). We compared the MTTI incidence between the groups for each age as well as between those for each calendar year.Results: A significant reduction in the MTTI incidence was detected in the 1-year-old children of the PCV era compared to those of the pre-PCV era. The reduction rates were more prominent in the 12-17 months group as compared to the 18-23 months group (PCV7 p = .005 and PCV13 p = .011, PCV7 p = .014 and PCV13 p = .153, respectively). The significant difference in the 1-year-old children continued in six of seven calendar years from 2011 to 2017, whereas no significant reduction was detected in children >3 years old. Conclusions:The introduction of both PCV7 and PCV13 reduced MTTI incidences in children around 1 year old, and the effects were more prominent during the early half-periods. Our results support etiological evidence that pneumococcal infection in children aged 1 year and younger might play roles in the pathogenesis of ComOM that requires MTTI.

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Impact of Pneumococcal Conjugate Vaccine on Pediatric Tympanostomy Tube Insertion in Partial Immunized Population

Cited by 5 publications

References 67 publications

Efficacy of Pneumococcal Vaccine on Otitis Media: A Systematic Review and Meta‐Analysis

Efficacy of Pneumococcal Vaccine on Otitis Media: A Systematic Review and Meta‐Analysis

<p>Investigation of Antibiotic Resistance, Serotype Distribution, and Genetic Characteristics of 164 Invasive <em>Streptococcus pneumoniae</em> from North China Between April 2016 and October 2017</p>

Pneumococcal conjugate vaccines reduce myringotomy with tympanostomy tube insertion in young children in Japan

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