Impact of placental Plasmodium falciparum malaria infection on the Cameroonian maternal and neonate’s plasma levels of some cytokines known to regulate T cells differentiation and function

Djontu, Jean Claude; Siewe, S; Edene, Yolande Delphine Mpeke; Nana, Benderli Christine; Foko, Edwige Vanessa Chomga; Bigoga, Jude D.; Leke, Rose G. F.; Megnekou, Rosette

doi:10.1186/s12936-016-1611-0

Cited by 22 publications

(29 citation statements)

References 45 publications

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“…Our ndings were different from those reported by Bayoumi et al [11] and Chêne and et al [12] who found higher levels of IL-4 and IL-10 in the non-infected group. The ndings of the increased IL-6 levels in non-infected women is in agreement with the results of other studies [11,16,32,33].…”

Section: Discussionsupporting

confidence: 92%

“…The roles of IFN-γ and IL-10 in the malaria-infected women with maternal anemia and baby birth weight was controversially documented in a reviewed by Seitz et al [40]. Although Djontu et al [16] reported no signi cant association between IL-6 level, maternal hemoglobin and baby birth weight, an elevated level of IL-6 was associated with anemia in another study [30].…”

Section: Discussionmentioning

confidence: 98%

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Impact of placental malaria on maternal, placental and foetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan

Omer

Franco-Jarava²,

Noureldien

et al. 2020

Preprint

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Background Sequestration of Plasmodium falciparum infected cells in the placenta results in placental malaria (PM). It activates a mother's immune cells and induces secretion of inflammatory cytokines, which might influence pregnancy outcomes. This study aims to investigate the inflammatory environment in maternal peripheral, placental, and umbilical cord blood in response to PM and the extent to which this may influence maternal haemoglobin levels and birth weight Methods A total of 185 consenting Sudanese women from Blue Nile state were enrolled in a cross sectional conducted between Jan 2012-Dec2005. Malaria infection in the collected samples was determined microscopically, and ELISA was used to measure the plasma levels of the antibodies, IL-4, IL-6, IL-10, IL-17A, and INF γ in the collected positive and negative malaria samples. Results Elevated levels of antibodies, IL-4 and IL-10 and reduced levels of IL-6 were detected in the malaria positive samples in comparison to the negative ones in the three types of samples investigated. Maternal antibodies, IL-4 and IL-10 were significantly higher in the samples collected from the PM infected group compared to the non-infected control (P < 0.001). While the absence of PM was significantly associated with the IL-6 and maternal IFN-γ levels, maternal IL-17A, placental and umbilical cord IFN-γ levels showed no significant difference (P = 0.214, P = 0.065, P = 0.536 respectively) due to infection. Haemoglobin level and birth weight were increased in the group with high levels of IL-6 and IL-17A but not in the group with IL-4 and IL-10 levels. Only maternal peripheral FN-γ level was significantly positively correlated with maternal hemoglobin (r = 0.171, P = 0.020), and baby birth weight (r = 0.233, P = 0.001). Conclusion These results suggest that PM cross-reacts with the mother’s immune response and impairs her cytokine profile, which might alter maternal haemoglobin levels and the baby's birth weight.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Impact of placental malaria on maternal, placental and foetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan

Omer

Franco-Jarava²,

Noureldien

et al. 2020

Preprint

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“…Decreased levels of IL-27 have been found in infants with severe falciparum malaria [26]. IL-27 levels are elevated in placental and cord blood compared with peripheral blood immediately following delivery in falciparum infected women [15], while no clear pattern was found during P. vivax malaria [27]. This is, however, the first report of IL-27 levels in adult patients with falciparum malaria demonstrating increased plasma levels as compared with healthy controls and HIV-infected patients with similar febrile illness, independent of co-infection with HIV.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical suspicion of malaria was defined as a history of fever, chills, headache, mental confusion, dyspnea, vomiting and/or diarrhea, myalgia and/or general malaise in the absence of other symptoms and findings indicating other severe infections or conditions. Pregnancy was an exclusion criteria due to the different immune response compared to non-pregnancy [14,15]. Of the 212 screened patients, 129 had P. falciparum malaria as assessed by qualitative PCR and two had rapid diagnostic test (RDT) and malaria slide positive for P. falciparum giving a total of 131 malaria patients (median age 37 years [18-84 years], 47% women, 53% co-infected with HIV-1 [PCR and/or serological tests]).…”

Section: Description Of Study Design and Participantsmentioning

confidence: 99%

Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria

et al. 2020

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Background: The immune response during falciparum malaria mediates both harmful and protective effects on the host; however the participating molecules have not been fully defined. Interleukin (IL)-27 is a pleiotropic cytokine exerting both inflammatory and anti-inflammatory effects, but data on IL-27 in malaria patients are scarce. Methods: Clinical data and blood samples were collected from adults in Mozambique with P. falciparum infection, with (n = 70) and without (n = 61) HIV-1 co-infection, from HIV-infected patients with similar symptoms without malaria (n = 58) and from healthy controls (n = 52). In vitro studies were performed in endothelial cells and PBMC using hemozoin crystals. Samples were analyzed using enzyme immunoassays and quantitative PCR. Results: (i) IL-27 was markedly up-regulated in malaria patients compared with controls and HIV-infected patients without malaria, showing no relation to HIV co-infection. (ii) IL-27 was correlated with P. falciparum parasitemia and von Willebrand factor as a marker of endothelial activation, but not with disease severity. (iii) In vitro, IL-27 modulated the hemozoin-mediated cytokine response in endothelial cells and PBMC with enhancing effects on IL-6 and attenuating effects on IL-8. Conclusion: Our findings show that IL-27 is regulated during falciparum malaria, mediating both inflammatory and anti-inflammatory effects, potentially playing an immune-regulatory role during falciparum malaria.

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“…There are inconsistencies regarding whether levels of IL-6, a TH2 cytokine with both pro-and anti-inflammatory properties, increases or decreases in response to malaria. When compared to uninfected placentas, infected placentas have significantly decreased IL-6 (Moormann et al, 1999), although associations between increased levels of IL-6 and placental and peripheral P. falciparum parasitemia have been reported (Djontu et al, 2016). Importantly, elevated IL-6 levels in neonatal cord blood and amniotic fluid is an independent risk factor for intraventricular haemorrhage and periventricular leukomalacia in preterm infants; white matter lesions are seen in neonates born to mothers with elevated concentrations of TNF-α, IL-1β, and IL-6 in their amniotic fluid, while periventricular leukomalacia is seen in neonates with increased levels of IL-6 in cord blood plasma (Martinez et al, 1998;Yoon et al, 1997).…”

Section: Inflammatory Factorsmentioning

confidence: 95%

Establishing a conceptual framework of the impact of placental malaria on infant neurodevelopment

Lawford

Lee

Kumar

et al. 2019

International Journal of Infectious Diseases

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A novel conceptual framework to describe the relationship between placental malaria and adverse infant neurodevelopmental outcomes is proposed. This conceptual framework includes three distinct stages:(1) maternal and environmental risk factors for the development of placental malaria; (2) placental pathology and inflammation associated with placental malaria infection; and (3) postnatal impacts of placental malaria. The direct, indirect, and bidirectional effects of these risk factors on infant neurodevelopment across the three stages were critically examined. These factors ultimately culminate in an infant phenotype that not only leads to adverse birth outcomes, but also to increased risks of neurological, cognitive, and behavioural deficits that may impact the quality of life in this high-risk population. Multiple risk factors were identified in this conceptual framework; nonetheless, based on current evidence, a key knowledge gap is the uncertainty regarding which are the most important and how exactly they interact.

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Impact of placental Plasmodium falciparum malaria infection on the Cameroonian maternal and neonate’s plasma levels of some cytokines known to regulate T cells differentiation and function

Cited by 22 publications

References 45 publications

Impact of placental malaria on maternal, placental and foetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan

Impact of placental malaria on maternal, placental and foetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan

Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria

Establishing a conceptual framework of the impact of placental malaria on infant neurodevelopment

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