Impact of phytomedicines and their novel delivery systems as an alternative for the treatment of neurodegenerative disorders

Nakhate, Kartik T.; Mangrulkar, Shubhada V.; Badwaik, Hemant; Choudhary, Rajesh; Baghel, Madhuri; Goyal, Sameer N.; AJAZUDDIN, .

doi:10.1016/b978-0-323-99125-4.00011-1

Cited by 1 publication

(1 citation statement)

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“…There are trials of several promising and potent phyto-based formulations to treat AD, which are currently in the recruiting phase or in different stages. These formulations are anticipated to be potential sources in the development of anti-AD and other medicaments [176][177][178]. To summarize, while plant-based medicines have gained popularity, clinical trials are required to verify their safety and efficacy.…”

Section: Clinical Trialsmentioning

confidence: 99%

Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights

Nagori,

Nakhate,

Yadav

et al. 2023

Future Pharmacology

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Alzheimer’s disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment. It has become more prevalent in recent years. Therefore, understanding the pathophysiology of AD and developing efficient therapeutic strategies are essential. Moreover, the progression of the disease is unaffected by the pharmaceutical approaches discovered to date. Additionally, the failure of over 200 potential drug candidates in clinical trials over the past decade suggests the complexity and difficulty of both the disease and its underlying causes. Therefore, research focused on medicinal plant-based natural products in the search for novel neuroprotective therapeutic candidates for AD is essential. Indeed, several scientific investigations have demonstrated the efficacy of many medicinal plants and their principal phytochemicals in the treatment of AD. This review article covered the pathophysiological mechanisms of AD, the necessity for natural products as anti-AD treatments, and the most recent preclinical studies revealing the function of neuroprotective medicinal plants and their bioactive compounds in the effective management of AD. In addition, the review also presents clinical trial data of promising anti-AD formulations/agents of plant origin. Revealing recent findings and highlighting the clinical trial data related to the development of new treatments for AD would promote further research in this field and pave the way for the development of more effective and safe treatments for this debilitating disease.

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Section: Clinical Trialsmentioning

confidence: 99%