Impact of physicochemical properties of nasal spray products on drug deposition and transport in the pediatric nasal cavity model

Sosnowski, Tomasz R.; Rapiejko, Piotr; Sova, Jarosław; Dobrowolska, Katarzyna

doi:10.1016/j.ijpharm.2019.118911

Cited by 32 publications

(31 citation statements)

References 31 publications

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“…By contrast, a wider plume will result in dispersed deposition and thinner liquid films, which need more spray doses to reach the threshold. Based on the above two reasons (i.e., higher OL dose and easier to move), a narrow plume (i.e., 10°) is recommended over the conventional nasal devices, whose plume angles typically range from 20° to 50° [ 12 , 38 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

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Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study

April

Sami

2021

Pharmaceutics

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Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often suffered from a lack of quantitative dosimetry in the target region, which relied on the observer’s subjective perception of color changes in the endoscopy images. The objective of this study is to test the feasibility of gravitationally driven droplet translocation numerically to enhance the nasal spray dosages in the olfactory region and quantify the intranasal dose distribution in the regions of interest. A computational nasal spray testing platform was developed that included a nasal spray releasing model, an airflow-droplet transport model, and an Eulerian wall film formation/translocation model. The effects of both device-related and administration-related variables on the initial olfactory deposition were studied, including droplet size, velocity, plume angle, spray release position, and orientation. The liquid film formation and translocation after nasal spray applications were simulated for both a standard and a newly proposed delivery system. Results show that the initial droplet deposition in the olfactory region is highly sensitive to the spray plume angle. For the given nasal cavity with a vertex-to-floor head position, a plume angle of 10° with a device orientation of 45° to the nostril delivered the optimal dose to the olfactory region. Liquid wall film translocation enhanced the olfactory dosage by ninefold, compared to the initial olfactory dose, for both the baseline and optimized delivery systems. The optimized delivery system delivered 6.2% of applied sprays to the olfactory region and significantly reduced drug losses in the vestibule. Rheological properties of spray formulations can be explored to harness further the benefits of liquid film translocation in targeted intranasal deliveries.

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Section: Discussionmentioning

confidence: 99%

“…Nasal spray velocities and droplet sizes were modeled following the measurements in the literature, which are approximately 10 m/s and 60 ± 25 µm, respectively, for a typical nasal spray product [ 18 , 38 , 39 ]. In this study, monodisperse aerosol droplets were generated ( Figure 3 a).…”

Section: Methodsmentioning

confidence: 99%

Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study

April

Sami

2021

Pharmaceutics

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“…The deposition and penetration of drugs from nasal spray to nose are mainly determined by liquid atomization in the spraying nozzle and aerosol formation, and the released drug droplets are mainly deposited by impact, and then due to the interaction of airflow, the deposited liquid drug diffuses along the nasal surface. [92]. Nasal spray ( Figure 1C) is very suitable for the long-term daily administration of drugs; solution and suspension can be prepared into nasal spray [93].…”

Section: Nasal Spraymentioning

confidence: 99%

Current Perspective on Nasal Delivery Systems for Chronic Rhinosinusitis

2021

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Chronic rhinosinusitis is an upper respiratory disease during which topical drug treatment via the nasal cavity is the most actively utilized therapeutic strategy. In addition to steroids, antibiotics, and antifungal agents, which are widely used in clinical practice, research on novel topical agents to improve the bacterial biofilm or mucociliary clearance remains ongoing. Moreover, owing to the complex structure of the nasal cavity, the effects of nasal drug delivery vary depending on factors related to delivery fluid dynamics, including device, volume, and compounds. In this article, we review methods and compounds that have been applied to chronic rhinosinusitis management and introduce recent advances and future perspectives in nasal drug delivery for upper respiratory diseases.

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“…Cheng et al [3] evaluated four different nasal pumps and found that spray angle and droplet size of the nasal spray were critical parameters that influenced deposition pattern in the nasal airway. Kundoor and Dalby [20] and Sosnowski et al [21] demonstrated nasal spray deposition patterns in a human nose model using a color-based gel which revealed that lower viscosity formulations provided greater coverage than a higher viscosity formulation.…”

Section: Introductionmentioning

confidence: 99%

Primary break-up and atomization characteristics of a nasal spray

et al. 2020

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The primary objective of this research was to extract the essential information needed for setting atomization break up models, specifically, the Linear Instability Sheet Atomization (LISA) breakup model, and alternative hollow cone models. A secondary objective was to gain visualization and insight into the atomization break up mechanism caused by the effects of viscosity and surface tension on primary break-up, sheet disintegration, ligament and droplet formation. High speed imaging was used to capture the near-nozzle characteristics for water and drug formulations. This demonstrated more rapid atomization for lower viscosities. Image processing was used to analyze the near-nozzle spray characteristics during the primary break-up of the liquid sheet into ligament formation. Edges of the liquid sheet, spray break-up length, break-up radius, cone angle and dispersion angle were obtained. Spray characteristics pertinent for primary breakup modelling were determined from high speed imaging of multiple spray actuations. The results have established input data for computational modelling involving parametrical analysis of nasal drug delivery.

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Impact of physicochemical properties of nasal spray products on drug deposition and transport in the pediatric nasal cavity model

Cited by 32 publications

References 31 publications

Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study

Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study

Current Perspective on Nasal Delivery Systems for Chronic Rhinosinusitis

Primary break-up and atomization characteristics of a nasal spray

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