Impact of Physical Activity on Cancer Recurrence and Survival in Patients With Stage III Colon Cancer: Findings From CALGB 89803

Meyerhardt, Jeffrey A.; Heseltine, Denise; Niedzwiecki, Donna; Hollis, Donna; Saltz, Leonard B.; Mayer, Robert J.; Thomas, James P.; Nelson, Heidi; Whittom, Renaud; Hantel, Alexander; Schilsky, Richard L.; Fuchs, Charles S.

doi:10.1200/jco.2006.06.0863

Cited by 649 publications

(481 citation statements)

References 48 publications

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“…Such randomization should have evenly distributed the pre-diagnosis exercisers between the IG and the UCG. Of note Meyerhardt et al in their investigation of colorectal cancer survivors using data from the Nurses Health Survey, found that pre-diagnosis exercise did not affect colo-rectal specific mortality or overall mortality, but post-diagnosis exercise did confer reduced colo-rectal mortality (39). A third limitation (or criticism) of this study is that the monthly phone call received by the IG may have been largely responsible for the observed improvement in symptomatology, as opposed to the walking program.…”

Section: Discussionmentioning

confidence: 99%

A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients

Yeo

Burrell

Sauter

et al. 2012

Journal of the American College of Surgeons

106

141

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A progressive postresection walking program significantly improves fatigue and health-related quality of life in pancreas and periampullary cancer patients. Recommended Citation Yeo, Theresa; Burrell, Sherry A; Sauter, Patricia K; Kennedy, Eugene P; Lavu, Harish; Leiby, Benjamin E; and Yeo, Charles, "A progressive postresection walking program significantly improves fatigue and health-related quality of life in pancreas and periampullary cancer patients." (2012 Methods:One hundred and two patients with resected PPC consented to participate in this study and were randomized to either an Intervention Group (IG) or a Usual Care Group (UCG).Subjects completed visual analog scales, the FACIT-Fatigue Scale (FFS) and the Short Form36v2® after surgery and again 3 to 6 months after hospital discharge. Results:Patients in the IG and UCG were comparable with regard to demographics, comorbidities, cancer type and staging, type of resection, pre-op fatigue and pain levels, adjuvant therapy and baseline walking distance. Patients in the IG had significantly improved scores on the FFS at study completion, improved fatigue and pain scores, as well as overall physical functioning and mental health composite scores. At study completion, participants in the IG were walking twice as far and were significantly more likely to have continued walking or another form of exercise as compared to the UCG. Using hierarchical cluster analysis three mutually exclusive symptom groupings were identified in the cohort. Kaplan-Meier survival analysis did not indicate an overall survival benefit for the IG. Conclusion:This is the first prospective, randomized and controlled trial to report that participation in a home walking program confers a significant benefit in resected PPC patients

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Section: Discussionmentioning

confidence: 99%

A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients

Yeo

Burrell

Sauter

et al. 2012

Journal of the American College of Surgeons

106

141

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“…Systematic reviews conclude that exercise is a safe and feasible supportive intervention associated with significant improvements in patient-reported outcomes (e.g., quality of life, fatigue) as well as physiological outcomes (exercise tolerance, muscle strength) in cancer populations (3,21). Moreover, several landmark epidemiologic studies have provided the first evidence that regular moderate-intensity exercise is associated with a 30 -50% reduction in the risk of cancer-specific mortality and all-cause mortality following a diagnosis of early breast or colorectal cancer (14,16,28). As such, elucidation of the molecular mechanisms underlying this association is of paramount importance to optimize the safety and efficacy of exercise in cancer control.…”

mentioning

confidence: 99%

Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer

Jones

Viglianti

Tashjian

et al. 2010

Journal of Applied Physiology

106

113

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“…[47][48][49] The NSABP (National Surgical Adjuvant Breast and Bowel Project) trial, a retrospective study of patients with stage II and III colon cancer, showed that BMI of 35 kg/m 2 or greater had an increased risk of disease recurrence and death. A pre-diagnosis BMI ( 35 kg/m 2 ) was found to have a prognostic impact on outcomes in patients with stage II and III colorectal cancer undergoing adjuvant chemotherapy (ACCENT).…”

Section: Survivorshipmentioning

confidence: 99%

Surveillance and Survivorship after Treatment for Colon Cancer

Makhoul

Alva

Wilkins

2015

Clinics in Colon and Rectal Surgery

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Colorectal cancer is the third most common cancer diagnosed in the United States. Majority of patients have localized disease that is amenable to curative resection. Disease recurrence remains a major concern after resection. In addition, patients are at an increased risk for developing a second or metachronous colon cancer. The principal goal of surveillance following treatment of colon cancer is to improve disease-free and overall survival. Survivorship is a distinct phase following surveillance to help improve quality of life and promote longevity.

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Impact of Physical Activity on Cancer Recurrence and Survival in Patients With Stage III Colon Cancer: Findings From CALGB 89803

Abstract: Beyond surgical resection and postoperative adjuvant chemotherapy for stage III colon cancer, for patients who survive and are recurrence free approximately 6 months after adjuvant chemotherapy, physical activity appears to reduce the risk of cancer recurrence and mortality.

Cited by 649 publications

References 48 publications

A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients

A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients

Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer

Surveillance and Survivorship after Treatment for Colon Cancer

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