Impact of phylogeny on the inference of functional sectors from protein sequence data
Nicola Dietler,
Alia Abbara,
Subham Choudhury
et al.
Abstract:Statistical analysis of multiple sequence alignments of homologous proteins has revealed groups of coevolving amino acids called sectors. These groups of amino-acid sites feature collective correlations in their amino-acid usage, and they are associated to functional properties. Modeling showed that natural selection on an additive functional trait of a protein is generically expected to give rise to a functional sector. These modeling results motivated a principled method, called ICOD, which is designed to id… Show more
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