Impact of pesticides exposure during neurodevelopmental period on autism spectrum disorders – A focus on gut microbiota

Yang, Yongyi; Zhou, Shun; Xing, Ying; Yang, Guosheng; You, Mingdan

doi:10.1016/j.ecoenv.2023.115079

Cited by 6 publications

(2 citation statements)

References 118 publications

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“…Moreover, ASD is truly a disorder that occurs on a spectrum, with some individuals requiring little to no assistance with daily functioning and others showing significant deficits in various skills and needing day‐to‐day support. The causes of ASD are thought to be multifactorial, with environmental (Awadh et al, 2023; Yang et al, 2023), gestational (Sato et al, 2022), and genetic factors (Fang et al, 2023; Ghafouri‐Fard et al, 2023; Kereszturi, 2023) at play. Interestingly, several studies have begun to provide evidence that olfactory deficits are a common feature of individuals with ASD.…”

Section: Introductionmentioning

confidence: 99%

Deficits in olfactory system neurogenesis in neurodevelopmental disorders

Sweat,

Cheetham

2024

Genesis

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SummaryThe role of neurogenesis in neurodevelopmental disorders (NDDs) merits much attention. The complex process by which stem cells produce daughter cells that in turn differentiate into neurons, migrate various distances, and form synaptic connections that are then refined by neuronal activity or experience is integral to the development of the nervous system. Given the continued postnatal neurogenesis that occurs in the mammalian olfactory system, it provides an ideal model for understanding how disruptions in distinct stages of neurogenesis contribute to the pathophysiology of various NDDs. This review summarizes and discusses what is currently known about the disruption of neurogenesis within the olfactory system as it pertains to attention‐deficit/hyperactivity disorder, autism spectrum disorder, Down syndrome, Fragile X syndrome, and Rett syndrome. Studies included in this review used either human subjects, mouse models, or Drosophila models, and lay a compelling foundation for continued investigation of NDDs by utilizing the olfactory system.

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Section: Introductionmentioning

confidence: 99%

Deficits in olfactory system neurogenesis in neurodevelopmental disorders

Sweat,

Cheetham

2024

Genesis

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“…Environmental toxicants induce inflammation, oxidative stress, and mitochondrial dysfunction in the brain, leading to neuropathology [3]. Environmental risk factors include air pollution, nutritional deficiencies, pesticides, toxic metal exposures, infection, and brain trauma [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Is Autism a PIN1 Deficiency Syndrome? A Proposed Etiological Role for Glyphosate

Seneff,

Kyriakopoulos,

Nigh

2024

Preprint

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Autism is a neurodevelopmental disorder whose prevalence has increased dramatically in the United States over the past two decades. It is characterized by stereotyped behaviors and impairments in social interaction and communication. In this paper, we present evidence that autism can be viewed as a PIN1 deficiency syndrome. PIN1 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1) is a peptidylprolyl cis/trans isomerase, and it has widespread influences in biological organisms. Broadly speaking, PIN1 deficiency is linked to many neurodegenerative diseases, whereas PIN1 overexpression is linked to cancer. Death associated protein kinase 1 (DAPK1) strongly inhibits PIN1, and the hormone melatonin inhibits DAPK1. Melatonin deficiency is strongly linked to autism. It has recently been shown that glyphosate exposure to rats inhibits melatonin synthesis due to increased glutamate release from glial cells and increased expression of metabotropic glutamate receptors. Glyphosate's inhibition of melatonin leads to a reduction in PIN1 availability in neurons. In this paper, we show that PIN1 deficiency can explain many of the unique morphological features of autism, including increased dendritic spine density, missing or thin corpus callosum and reduced bone density. We show how PIN1 deficiency disrupts the functioning of powerful high level signaling molecules, such as nuclear factor erythroid 2-related factor 2 (NRF2) and p53. Dysregulation of both of these proteins has been linked to autism. Severe depletion of glutathione in the brain resulting from chronic exposure to oxidative stressors and extracellular glutamate leads to oxidation of the cysteine residue in PIN1, inactivating the protein and further contributing to PIN1 deficiency. Impaired autophagy leads to increased sensitivity of neurons to ferroptosis. Finally, we consider evidence of the potential toxic effects of the mRNA SARS-CoV-2 vaccines in the light of metabolic defects in autism, and we propose that children with autism would be especially sensitive to damage from the vaccines.

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Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures

Ahmad,

Alsayegh

et al. 2024

Heliyon

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Impact of pesticides exposure during neurodevelopmental period on autism spectrum disorders – A focus on gut microbiota

Cited by 6 publications

References 118 publications

Deficits in olfactory system neurogenesis in neurodevelopmental disorders

Deficits in olfactory system neurogenesis in neurodevelopmental disorders

Is Autism a PIN1 Deficiency Syndrome? A Proposed Etiological Role for Glyphosate

Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures

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