Impact of permeant cryoprotectors on under-membrane skeleton of human erythrocytes

Drug-loaded erythrocytes: Modern approaches for advanced drug delivery for clinical use

“…This suggests a potential partitioning of CPZ influenced by the solvent. The authors [ 78 ] utilized thermal dielectroscopy to investigate the effects of formamide, N-methylformamide, N,N-dimethylformamide and dimethyl sulfoxide on the segmental mobility and binding of the spectrin-based skeleton to the lipid membrane of human erythrocytes. The DMSO method yields highly loaded RBCs, but only a small fraction of cells (approximately 9%–25 %) are affected.…”