Impact of perioperative transfusion in patients undergoing resection of colorectal cancer liver metastases: A population-based study

Long, Bo; Xiao, Zhennan; Shang, Lihua; Pan, Bo-Yan; Chai, Jing

doi:10.12998/wjcc.v7.i10.1093

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…Moreover, a recent study could also demonstrate higher risks for postoperative morbidity depending on intraoperative transfusion requirements [ 30 ]. These findings are supported by a population-based study from the USA that reported increased risk for in-hospital mortality, morbidity and longer hospital stay [ 10 ]. A systematic review by Acheson et al recommended restrictive use of PRBC in surgeries of primary colorectal cancer (CRC) due to negative impacts on clinical parameters such as overall and cancer-related mortality [ 31 ].…”

Section: Discussionsupporting

confidence: 61%

“…In fact, some centers report that up to one third of resected patients require blood transfusions with different extent [ 9 ]. Over the past years many studies have reported inferior OS in case of intensive intra- or postoperative transfusions of packed red blood cells (PRBC) [ 10 – 12 ]. Negative effects of blood transfusions have been described for various tumor entities such as esophageal cancer, hepatocellular carcinoma, non-small-cell lung cancer, and urothelial carcinoma [ 13 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of perioperative blood transfusions on postoperative renal function and survival after resection of colorectal liver metastases

et al. 2022

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Background and aims Recent studies focusing on thoracic surgery suggest postoperative kidney injury depending on the amount of perioperative blood transfusions. Data investigating similar effects after resection of colorectal liver metastases (CRLM) are not available. Aim of this study was therefore to evaluate the influence of perioperative blood transfusions on postoperative renal function and survival after resection of CRLM. Methods Seven hundred twenty-seven cases of liver resection for CRLM were retrospectively analyzed. Renal function was measured via estimated glomerular filtration rate (eGFR) and a postoperative decline of ≥ 10% was considered substantial. Potential influences on postoperative kidney function were assessed using univariable and multivariable logistic regression analyses. Cox-regression analyses were performed to estimate the impact on overall survival (OS). Results Preoperative impaired kidney function (p = 0.001, OR 2.477) and transfusion of > 2 units of packed red blood cells (PRBC) (p = 0.046; OR 1.638) were independently associated with an increased risk for ≥ 10% loss of renal function. Neither a pre-existing renal impairment, nor the additional loss of renal function were associated with reduced survival. Chemotherapies in the context of primary colorectal cancer treatment (p = 0.002), age > 70 years at liver resection (p = 0.005), number (p = 0.001), and size of metastases > 50 mm (p = 0.018), duration of resection > 120 min (p = 0.006) and transfusions of > 2 units of PRBC (p = 0.039) showed a negative independent influence on OS. Conclusion The results demonstrate a negative impact of perioperative blood transfusions on the postoperative renal function and OS. Hence, efforts to reduce blood transfusions should be intensified.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Impact of perioperative blood transfusions on postoperative renal function and survival after resection of colorectal liver metastases

et al. 2022

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“…Restrictive transfusion strategies can reduce the adverse prognosis of diseases and save the cost of national health resources compared with liberal transfusion strategies. Mortality of transfused patients has been demonstrated to be higher than that of non-transfused patients, other adverse events such as postoperative complications, myocardial infarction, congestive heart failure and respiratory complications are also at a higher risk [7,8]. At the same time, the economic burden on the state and patients caused by the waste of RBC resources should be taken into account.…”

Section: Introductionmentioning

confidence: 99%

Restrictive versus liberal transfusion strategies in patients with malignant neoplasm -a meta-analysis of randomized controlled trials

Yang¹,

Dai²,

Liu³

et al. 2020

Transfusion and Apheresis Science

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Background: Transfusion strategies are involving the survival and prognosis of patients with malignant neoplasm and the rational utilization of medical resources, but there are still controversy between different transfusion strategies. The aim of this article is to compare the benefit and harm of restrictive and liberal red blood cell(RBC) transfusion strategies in patients with malignant tumors. Methods: We searched articles in the databases of PubMed, Cochrane Library, Web of Science, Embase and major conference proceedings, identified all randomized controlled trials (RCTs) and compared restrictive transfusion strategies with those that are liberal until MARCH 18, 2019. We used risk ratio (RR) and and 95 % confidence interval (95 %CI) to calculate the results of dichotomous variables, and the study heterogeneity was assessed by using the I 2 statistics. Also, we did sensitivity analysis and quality assessment. Results: Restrictive transfusion policies appear to have no effect on all-cause mortality (RR 1.33; 95 % CI 0.74-2.38; P = 0.34), compared with liberal policies. 2 trials including 498 patients were included of renal replacement therapy (RR 1.38; 95 % CI, 0.73-2.59; P = 0.32; I 2 = 0%). Myocardial infarction (RR 1.17; 95 % CI, 0.33-4.1; P = 0.81; I 2 = 0%) and ICU readmission were also mentioned in these articles (RR 1.19; 95 % CI, 0.7-2.04; P = 0.52; I 2 = 0%). However, the RR of hospital length can't be evaluated. Conclusion:Restrictive transfusion strategies were not associated with all-cause mortality and other clinical outcomes in malignant tumors, and may be more suitable for patients' quality of life and medical economy than liberal.

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“…A large proportion of the genome in human cells is transcribed into RNA molecules that lack protein-coding capacity (3,4). Of these, long non-coding RNAs (lncRNAs) are transcripts with lengths >200 nt (5) that play important roles in tumorigenesis and cancer progression (6–8). A growing number of gastric cancer-related lncRNAs have been identified in recent years.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of expression profiles of long non‑coding RNAs with associated ceRNA�network involved in gastric cancer progression

Ren²,

Zheng

et al. 2019

Mol Med Report

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long non-coding rnas (lncrnas) play critical roles in the development and progression of cancers. The present study aimed to identify novel lncrnas and associated micrornas (mirnas or mirs) and mrnas in gastric cancer. differentially expressed lncrnas (delncrnas) and differentially expressed mrnas (demrnas) of 6 paired gastric cancer and normal tissues were identified using microarray. The demirnas between gastric cancer and the normal control tissues were identified using mirna-seq data from cancer Genome atlas. common delncrnas from the cancer rna-Seq nexus database and circlncrnanet database were analyzed. a delncrnas-demirnas-demrnas network was constructed by target prediction. Functional enrichment analysis was employed to predict the function of demrnas in the network. The correlation between the expression of delncrnaS and demrnas in the network was analyzed. The expression levels of several genes were validated by reverse transcription-quantitative polymerase chain reaction (rT-qPcr). a total of 1,297 delncrnas, 2,037 demrnas and 171 DEmiRNAs were identified. Among the 4 lncRNAs common to the 3 datasets, prostate androgen-regulated transcript 1 (ParT1) was selected for further analysis. The analysis identified 5 DEmiRNAs and 13 DEmRNAs in the ParT1-mediated cerna network. The demrnas in the cerna network were markedly enriched in cancer-related biological processes (response to hypoxia, positive regulation of angiogenesis and positive regulation of endothelial cell proliferation) and pathways (cGMP-PKG signaling pathway, caMP signaling pathway and proteoglycans in cancer). out of the 13 demrnas, 11 were positively associated with ParT1. The downregulation of ParT1, myosin light chain 9 (MYl9), potassium calcium-activated channel subfamily M alpha 1 (KcnMa1), cholinergic receptor muscarinic 1 (cHrM1), solute carrier family 25 member 4 (SLC25A4) and ATPase na + /K + transporting subunit alpha 2 (aTP1a2) expression levels in gastric cancer was validated by rT-qPcr. on the whole, the current study identified a novel lncrna and associated mirnas and mrnas that are involved in the pathogenesis of gastric cancer that may serve as potential therapeutic targets for the treatment of gastric cancer.

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Impact of perioperative transfusion in patients undergoing resection of colorectal cancer liver metastases: A population-based study

Cited by 5 publications

References 16 publications

Impact of perioperative blood transfusions on postoperative renal function and survival after resection of colorectal liver metastases

Impact of perioperative blood transfusions on postoperative renal function and survival after resection of colorectal liver metastases

Restrictive versus liberal transfusion strategies in patients with malignant neoplasm -a meta-analysis of randomized controlled trials

Comprehensive analysis of expression profiles of long non‑coding RNAs with associated ceRNA�network involved in gastric cancer progression

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