Impact of perfusion on neuronal development in human derived neuronal networks
Donatella Di Lisa,
Andrea Andolfi,
Giacomo Masi
et al.
Abstract:Advanced in vitro models of the brain have evolved in recent years from traditional two-dimensional (2D) ones, based on rodent derived cells, to three-dimensional (3D) ones, based on human neurons derived from induced pluripotent stem cells. To address the dynamic changes of the tissue microenvironment, bioreactors are used to control the in vitro microenvironment for viability, repeatability, and standardization. However, in neuronal tissue engineering, bioreactors have primarily been used for cell expansion … Show more
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