Impact of Percutaneous Coronary Intervention on Exercise-Induced Repolarization Changes in Patients With Stable Coronary Artery Disease

Jukić, Anita; Carević, Vedran; Zekanović, Dražen; Stojanović-Stipić, Sanda; Runjić, Frane; Ljubković, Marko; Fabijanić, Damir

doi:10.1016/j.amjcard.2015.06.009

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Several studies also demonstrated that the revascularization of ischemic myocardium decreases the arrythmogenic potential by reducing myocardial TDR. [14][15][16] In the present study, although the increased TDR gradually decreased after PCI, the significant decrease in the TDR was observed at least 24 hours after PCI. Figure 3.…”

Section: Discussionmentioning

confidence: 38%

Time Variance of Electrocardiographic Transmural Dispersion in Acute Myocardial Infarction

et al. 2016

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Background and Objectives: The mechanism responsible for lethal ventricular arrhythmia (LVA) after acute myocardial infarction (AMI) remains unclear. Subjects and Methods: The corrected QT interval (QTc) and interval from the peak to the end of the T wave (TpTe) were measured, which indicated myocardial transmural dispersion of repolarization (TDR) in 72 patients with AMI. TpTe was also expressed as a corrected value, [TpTe/QTe]x100% and TpTe/√RR. These parameters were obtained from all the 12-leads of electrocardiography after arrival at the hospital, just before and after percutaneous coronary intervention (PCI), and at 4, 24, and 48 hours and 5 days after PCI. Results: Analyzing with repeated measures analysis of variance, the TpTe, [TpTe/QTe]x100% and TpTe/√RR after AMI showed significant changes in time variance. The patients were divided into LVA (17 patients, 24%) and non-LVA group (55 patients, 76%). The [TpTe/ QTe]×100% (V 2 : 25±7% vs. 22±5%, p=0.036) and TpTe/√RR (V 2 : 109 ± 42 ms vs. 88 ± 22 ms, p=0.05, V 3 : 108±39 ms vs. 91±27 ms, p=0.048) in V 2 and V 3 leads were prolonged in the LVA group after PCI. The [TpTe/QTe]×100% (28±9 % vs. 22±5%, p=0.025) and TpTe/√RR (129±53 ms vs. 99±41 ms, p=0.05) in V 3 lead were prolonged in the LVA group 24 hours after PCI. Conclusion: The mechanisms responsible for LVA after AMI may be associated with increased TDR, and PCI may have an important role in reducing LVA.

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Section: Discussionmentioning

confidence: 38%

Time Variance of Electrocardiographic Transmural Dispersion in Acute Myocardial Infarction

et al. 2016

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“…They are both common indicators to evaluate the function of the cardiovascular system. Tpe and Tpe/QT have also been proven to be important indicators for predicting cardiovascular events, and they are of great significance for disease prognosis and risk stratification [ 51 , 52 , 53 ]. Meanwhile, abnormal STI and DTI in PCG signals also play an important role in the evaluation of cardiovascular function [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Discrimination of Patients with Varying Degrees of Coronary Artery Stenosis by ECG and PCG Signals Based on Entropy

Zhang

Wang

Liu

et al. 2021

Entropy

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Coronary heart disease (CHD) is the leading cause of cardiovascular death. This study aimed to propose an effective method for mining cardiac mechano-electric coupling information and to evaluate its ability to distinguish patients with varying degrees of coronary artery stenosis (VDCAS). Five minutes of electrocardiogram and phonocardiogram signals was collected synchronously from 191 VDCAS patients to construct heartbeat interval (RRI)–systolic time interval (STI), RRI–diastolic time interval (DTI), HR-corrected QT interval (QTcI)–STI, QTcI–DTI, Tpeak–Tend interval (TpeI)–STI, TpeI–DTI, Tpe/QT interval (Tpe/QTI)–STI, and Tpe/QTI–DTI series. Then, the cross sample entropy (XSampEn), cross fuzzy entropy (XFuzzyEn), joint distribution entropy (JDistEn), magnitude-squared coherence function, cross power spectral density, and mutual information were applied to evaluate the coupling of the series. Subsequently, support vector machine recursive feature elimination and XGBoost were utilized for feature selection and classification, respectively. Results showed that the joint analysis of XSampEn, XFuzzyEn, and JDistEn had the best ability to distinguish patients with VDCAS. The classification accuracy of severe CHD—mild-to-moderate CHD group, severe CHD—chest pain and normal coronary angiography (CPNCA) group, and mild-to-moderate CHD—CPNCA group were 0.8043, 0.7659, and 0.7500, respectively. The study indicates that the joint analysis of XSampEn, XFuzzyEn, and JDistEn can effectively capture the cardiac mechano-electric coupling information of patients with VDCAS, which can provide valuable information for clinicians to diagnose CHD.

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T-Wave Indices and Atherosclerosis

Tse

Bazoukis

Roever

et al. 2018

Curr Atheroscler Rep

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Tpeak-Tend interval, the time difference between the peak and the end of the T-wave, reflects the degree of dispersion of repolarization. Its prolongation has been associated with higher risks of developing ventricular arrhythmias and sudden cardiac death in different pro-arrhythmic conditions such as Brugada and long QT syndromes. In this review, we will provide a comprehensive overview on how Tpeak-Tend is altered in different atherosclerotic conditions such as hypertension, stable coronary artery disease, acute coronary obstruction, and coronary slow flow as well as inflammatory diseases affecting the arterial tree. We will explore its relationship with arterial function and dysfunction, ventricular remodeling, and arrhythmic and mortality outcomes. The published literature shows that patients with coronary atherosclerosis, whether in the form of stable coronary artery disease, chronic total occlusion, slow flow, or acute coronary obstruction, have prolonged Tpeak-Tend intervals and Tpeak-Tend/QT ratios. These can be used to predict the occurrence of ventricular arrhythmias and sudden cardiac death. They also correlate with the extent and severity of arterial stenosis and structural remodeling of the ventricles as well as arterial function and dysfunction. Finally, they can be normalized following revascularization and may therefore be used as a surrogate measure of treatment success.

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Impact of Percutaneous Coronary Intervention on Exercise-Induced Repolarization Changes in Patients With Stable Coronary Artery Disease

Cited by 5 publications

References 15 publications

Time Variance of Electrocardiographic Transmural Dispersion in Acute Myocardial Infarction

Time Variance of Electrocardiographic Transmural Dispersion in Acute Myocardial Infarction

Discrimination of Patients with Varying Degrees of Coronary Artery Stenosis by ECG and PCG Signals Based on Entropy

T-Wave Indices and Atherosclerosis

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