Impact of Peppermint Therapy on Dysphagia and Non-cardiac Chest Pain: A Pilot Study

Khalaf, Mohamed; Chowdhary, Sejal; Elmunzer, B. Joseph; Elias, Puja S.; Castell, Donald O.

doi:10.1007/s10620-019-05523-8

Cited by 22 publications

(14 citation statements)

References 14 publications

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“…The pooled clinical success rate of all interventions, defined as the pooled proportion of patients having clinical improvement with treatment, was 73.6% [95% CI: 64.0%‐83.1%; Cochran's Q = 19.9, I 2 = 54.9%] 20,21,23,25,31,49‐53 (Figure 5). We did not detect any publication bias using Egger's test ( P = .290).…”

Section: Resultsmentioning

confidence: 99%

“…There were insufficient data to pool outcomes of individual treatments (except for POEM), so we pooled data into two categories: medical or endoscopic. Medical treatment (pooling data on calcium channel blockers, nitrates, PPIs, peppermint oil, and antidepressants) resulted in a pooled clinical success rate of 62.6% [95% CI: 46.5%‐78.7%; Cochran's Q = 9.2, I 2 = 45.8%] 20,21,23,25,31,52 . Endoscopic treatment (pooling data on endoscopic dilation, endoscopic Botox injection, and POEM) resulted in a pooled clinical success rate of 79.4% [95% CI: 74.2%‐84.5%; Cochran's Q = 2.8, I 2 = 0%] 21,23,25,31,49‐51,53 and this was significantly superior to medical treatment ( P = .012) (Figure 5).…”

Section: Resultsmentioning

confidence: 99%

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Jackhammer esophagus: A meta‐analysis of patient demographics, disease presentation, high‐resolution manometry data, and treatment outcomes

Wahba

Bouin

2020

Neurogastroenterology Motil

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Background: Jackhammer esophagus (JE) is a newly described esophageal motility disorder. However, there are limited data on JE and this entity remains misunderstood. Methods: We performed a systematic review of clinical series on JE through MEDLINE, EMBASE, and Web of Science. Data from included studies were then extracted, and random-effects meta-analyses were performed. Results: Thirty-eight studies met inclusion criteria. The pooled prevalence of JE was 1.97% [95% CI: 1.39%-2.78%] among patients referred for high-resolution manometry (HRM). The mean age at diagnosis was 60.8 years [95% CI: 57.1-64.4] and 65% [95% CI: 58%-72%] of patients were female. JE was significantly more prevalent in postlung transplant patients and morbidly obese patients undergoing HRM (23.99% [95% CI: 9.00%-38.97%] and 5.18% [95% CI: 1.76%-14.3%] respectively). Dysphagia was the most common presentation of JE (64% [95% CI: 52%-77%]) followed by gastroesophageal reflux disease (46% [95% CI: 26%-67%]). The pooled mean distal contractile integral (DCI) of all standard HRM swallows was 9249 mm Hg•s•cm [95% CI: 7834-10 663], and the pooled mean integrated relaxation pressure (IRP) was 13.9 mm Hg [95% CI: 8.2-19.7]. Overall, 73.6% [95% CI: 64.0%-83.1%] of JE patients who underwent treatment achieved clinical symptom improvement (79% [95% CI: 74%-85%] for endoscopic treatment and 63% [95% CI: 47%-79%] for medical treatment). The pooled clinical success rate of peroral endoscopic myotomy (POEM) specifically was 82% [95% CI: 75%-90%]. Conclusions: JE is a new motility disorder most commonly presenting with dysphagia. High clinical suspicion is important because the diagnosis can only be made through HRM.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Jackhammer esophagus: A meta‐analysis of patient demographics, disease presentation, high‐resolution manometry data, and treatment outcomes

Wahba

Bouin

2020

Neurogastroenterology Motil

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“…Thirty-eight patients were included in the study; among these, 63% of patients reported complete symptom resolution, and the remaining patients reported mild-tomoderate symptom improvement. This study involved not only patients with DES but also those with esophagogastric junction outflow obstruction, hypercontractile esophagus, ineffective esophageal motility, and symptomatic patients with normal motility testing [17]. In our case study, we managed an elderly patient with comorbidities who was best treated with peppermint oil treatment in order to avoid side effects that accompany other medications such as nitrates and calcium channel blockers.…”

Section: Discussionmentioning

confidence: 99%

Role of Peppermint Oil in Diffuse Esophageal Spasm in the Geriatric Population

Parvataneni

Vemuri-Reddy

2020

Cureus

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Diffuse esophageal spasm, also known as distal esophageal spasm (DES), is a rare motility disorder among the population with symptomatic motility disorders. This disorder is most commonly reported in females, with a median age of 60 years. Multiple therapeutic options have been developed for the treatment of DES. There has been limited research regarding the use of peppermint oil in the treatment of DES. Here, we discuss the interesting case of an elderly female patient who received symptomatic relief from peppermint oil.

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“…64 The most recent study showed that PO reduced dysphagia and chest pain in 83% with DES and 100% with EGJOO making this a promising therapy for spastic and obstructive esophageal conditions. 65…”

Section: Peppermint Oilmentioning

confidence: 99%

The Impact of Medications on Esophageal Motility

Snyder

Ravi

2021

Foregut

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The purpose of this review is to highlight the impact of common medications on esophageal motility. Esophageal motility is mediated through a complex network of neural innervation. Opioids lead to excitatory esophageal motor abnormalities termed opioid-induced esophageal dysfunction or OIED. Prokinetics have mixed effects on esophageal motility. Nitrates and calcium channel blockers relax esophageal smooth muscle, but they are limited clinically due to side effects. Sildenafil also relaxes smooth muscle, but it is costly. Peppermint oil may reduce distal esophageal spasm. Anticholinergics, selective serotonin reuptake inhibitors, estrogen, and cannabis need further study to evaluate their effects on esophageal motility.

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Impact of Peppermint Therapy on Dysphagia and Non-cardiac Chest Pain: A Pilot Study

Cited by 22 publications

References 14 publications

Jackhammer esophagus: A meta‐analysis of patient demographics, disease presentation, high‐resolution manometry data, and treatment outcomes

Jackhammer esophagus: A meta‐analysis of patient demographics, disease presentation, high‐resolution manometry data, and treatment outcomes

Role of Peppermint Oil in Diffuse Esophageal Spasm in the Geriatric Population

The Impact of Medications on Esophageal Motility

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