Impact of Pelvic Lymph Node Dissection and Its Extent on Perioperative Morbidity in Patients Undergoing Radical Prostatectomy for Prostate Cancer: A Comprehensive Systematic Review and Meta-analysis

Cacciamani, Giovanni; Maas, Marissa; Nassiri, Nima; Ortega, David G.; Gill, Karanvir; Dell’Oglio, Paolo; Thalmann, George N.; Heidenreich, Axel; Eastham, James A.; Evans, Christopher P.; Karnes, R. Jeffrey; Abreu, André Luís de Castro; Briganti, Alberto; Artibani, Walter; Gill, Inderbir S.; Montorsi, Francesco

doi:10.1016/j.euo.2021.02.001

Cited by 66 publications

(69 citation statements)

References 55 publications

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“…These wide ranges might be explained by variations in recording and reporting of perioperative complication data. The robustness of our data is ensured by the fact that, differently from the aforementioned studies [25] , we relied on the standardised methodology proposed by the EAU guidelines to collect postoperative complications [18] , which was proved to avoid missing critical information that could lead to an underestimation of perioperative complications [30] , [31] , [32] , [33] .…”

Section: Discussionmentioning

confidence: 99%

Retzius-sparing Robot-assisted Radical Prostatectomy in High-risk Prostate Cancer Patients: Results from a Large Single-institution Series

Dell’Oglio

Tappero

Longoni

et al. 2022

European Urology Open Science

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Section: Discussionmentioning

confidence: 99%

Retzius-sparing Robot-assisted Radical Prostatectomy in High-risk Prostate Cancer Patients: Results from a Large Single-institution Series

Dell’Oglio

Tappero

Longoni

et al. 2022

European Urology Open Science

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“… 7 , 8 The rationale underlying this approach is to combine a wide bilateral prophylactic fenestration of the pelvic peritoneum with the fixation of resorptive peritoneal flaps immediately adjacent to the area of PLND. 9 …”

mentioning

confidence: 99%

Bilateral Peritoneal Flaps Reduce Incidence and Complications of Lymphoceles after Robotic Radical Prostatectomy with Pelvic Lymph Node Dissection—Results of the Prospective Randomized Multicenter Trial ProLy

et al. 2022

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“…considering that ePLND might potentially be associated with treatment-related complications [48,49]. Moreover, nomograms do not provide any information regarding the topography of possible nodal disease dissemination.…”

Section: Random-effects M Odelmentioning

confidence: 99%

Can Negative Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Avoid the Need for Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients? A Systematic Review and Meta-analysis with Backup Histology as Reference Standard

Stabile

Pellegrino

Mazzone

et al. 2022

European Urology Oncology

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Context: The role of positron emission tomography/computed tomography (PET/ CT) with prostate-specific membrane antigen (PSMA) in the primary staging for patients with prostate cancer (PCa) is still debated. Objective: To analyze published studies reporting the accuracy of PSMA PET/CT for detecting lymph node invasion (LNI) at pelvic lymph node dissection (PLND). Evidence acquisition: A search of PubMed/MEDLINE, Cochrane library's Central, EMBASE and Scopus databases, from inception to May 2021, was conducted. The primary outcome was to evaluate the sensitivity, specificity, positive (PPV) and negative (NPV) predictive values of PSMA PET/CT in detecting LNI on a per-patient level. As a secondary outcome, NPV of PET PSMA was tested on a per-node-level analysis. Detection rates were pooled using random-effect models. Preplanned subgroup analyses tested the diagnostic accuracy after stratification for the preoperative risk group. PPV and NPV variation over LNI prevalence was evaluated. Only studies including extended PLND (ePLND) as the reference standard test were included. Evidence synthesis: Twenty-seven studies, with a total of 2832 participants, were included in quantitative synthesis. The sensitivity, specificity, PPV, and NPV of y These authors contributed equally to this study.

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Impact of Pelvic Lymph Node Dissection and Its Extent on Perioperative Morbidity in Patients Undergoing Radical Prostatectomy for Prostate Cancer: A Comprehensive Systematic Review and Meta-analysis

Cited by 66 publications

References 55 publications

Retzius-sparing Robot-assisted Radical Prostatectomy in High-risk Prostate Cancer Patients: Results from a Large Single-institution Series

Retzius-sparing Robot-assisted Radical Prostatectomy in High-risk Prostate Cancer Patients: Results from a Large Single-institution Series

Bilateral Peritoneal Flaps Reduce Incidence and Complications of Lymphoceles after Robotic Radical Prostatectomy with Pelvic Lymph Node Dissection—Results of the Prospective Randomized Multicenter Trial ProLy

Can Negative Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Avoid the Need for Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients? A Systematic Review and Meta-analysis with Backup Histology as Reference Standard

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