Impact of PD-1 gene polymorphism and its interaction with tea drinking on susceptibility to tuberculosis

Abstract

The aim of this study was to explore the impact of polymorphism of PD-1 gene and its interaction with tea drinking on susceptibility to tuberculosis (TB). A total of 503 patients with TB and 494 controls were enrolled in this case–control study. Three single-nucleotide polymorphisms of PD-1 (rs7568402, rs2227982 and rs36084323) were genotyped and unconditional logistic regression analysis was used to identify the association between PD-1 polymorphism and TB, while marginal structural linear odds models were used to estimate the interactions. Genotypes GA (OR 1.434), AA (OR 1.891) and GA + AA (OR 1.493) at rs7568402 were more prevalent in the TB patients than in the controls (P < 0.05). The relative excess risk of interaction (RERI) between rs7568402 of PD-1 genes and tea drinking was −0.3856 (95% confidence interval −0.7920 to −0.0209, P < 0.05), which showed a negative interaction. However, the RERIs between tea drinking and both rs2227982 and rs36084323 of PD-1 genes were not statistically significant. Our data demonstrate that rs7568402 of PD-1 genes was associated with susceptibility to TB, and there was a significant negative interaction between rs7568402 and tea drinking. Therefore, preventive measures through promoting the consumption of tea should be emphasised in the high-risk populations.

Association of tuberculosis risk with genetic polymorphisms of the immune checkpoint genes PDCD1, CTLA-4, and TIM3

“…Previous groups have reported that some polymorphisms of PDCD1 , CTLA4 , and HAVCR2 are associated with TB risk [ 25 – 28 ]. In this study, we found a sex-dependent association of TB risk with the AG genotype of PDCD1 rs2227982, TC genotype of HAVCR2 rs13170556, AG genotype of CTLA4 rs231775, and CT genotype of CTLA4 rs231779.…”

“…Associations of TB susceptibility with some single nucleotide polymorphisms (SNPs) of PDCD1 and CTLA4 have been reported [25][26][27]. In PDCD1, rs7568402 is linked to increased TB risk [25], and rs3087243 AA in CTLA4 is negatively associated with severe pathology in pulmonary TB [26].…”

“…Associations of TB susceptibility with some single nucleotide polymorphisms (SNPs) of PDCD1 and CTLA4 have been reported [25][26][27]. In PDCD1, rs7568402 is linked to increased TB risk [25], and rs3087243 AA in CTLA4 is negatively associated with severe pathology in pulmonary TB [26]. In people of Southern Han Chinese ethnicity, rs231775 AG in CTLA4 has been associated with reduced risk for TB infection [27].…”