Impact of paternal age on intracytoplasmic sperm injection cycle results

Temel, Tuğçe; Akpak, Yaşam Kemal; Gün, İsmet; Oral, Serkan; Sofuoǧlu, Kenan

doi:10.18203/2320-1770.ijrcog20150063

Cited by 3 publications

(3 citation statements)

References 25 publications

(34 reference statements)

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“…Etiology of infertility includes male infertility (30%), female infertility (35%), combined infertility (20%) and unexplained infertility (15%). 1,2 In addition to these main causes other most significant factors having impact over fertilization, implantation and fetal development are immunological in origin. Antithyroid antibodies (ATA) are well studied part of immunological mechanisms having negative impact over fertility and also ART.…”

Section: Introductionmentioning

confidence: 99%

Thyroid disorders and fertility

Karaca

Akpak

2015

Int J Res Med Sci

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Section: Introductionmentioning

confidence: 99%

Thyroid disorders and fertility

Karaca

Akpak

2015

Int J Res Med Sci

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“…In the modern world, most of the couples marry in advanced ages due to concern for the future, have babies in advanced ages. This situation increases the application of assisted reproduction techniques [1]. The ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of ovarian stimulation treatments for ovulation induction and in vitro fertilization with the incidence of severe forms, 0.1% -5% [2].…”

Section: Introductionmentioning

confidence: 99%

The Importance of Prolactin Levels in Patients Treated with Cabergoline for the Prevention of OHSS: Is Cabergoline Really Effective in Patients with High Risk of OHSS?

Oral¹,

Akpak²,

Karaca³

et al. 2015

OJOG

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Background: OHSS is a dangerous and potentially life-threatening condition for which many researchers look for new ways to treat. Aim: To determine the effectiveness of prophylactic cabergoline administration on prolactine levels in patients with high risk for ovarian hyperstimulation syndrome (OHSS). Material and Methods: 163 in vitro fertilisation (IVF) patients with high risk for OHSS were enrolled in the study. The criteria for inclusion were more than 15 oocytes retrieved at oocyte pick up. A standard antagonist protocol was used for ovulation induction. Cabergoline treatments (0.5 mg/day) were started on the day of oocyte retrieval and continued for eight days. Prolactine levels were measured at the day of oocyte retrieval and the 9th day after the oocyte retrieval. Results: Of the 163 patients, 26 (15.9%) had OHSS. Prolactine levels on the day of oocyte retrieval were 44.22 ± 24.78 ng/mL and 37.6 ± 22.5 ng/mL in patients with OHSS and without OHSS, respectively (P > 0.05). In contrary prolactine levels were significantly higher in patients with OHSS patients (3.9 ± 5.07 ng/mL) than in patients without OHSS (2.1 ± 2.92 ng/mL) at the 9th day after oocyte retrieval (P < 0.05). Conclusion: Prolactine levels were higher in patients with OHSS than without OHSS who were treated with cabergoline for the prevention of OHSS.

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“…The treatment success of in vitro fertilization (IVF) is based on various factors, including the number of retrieved oocytes [ 1 ]. Failure to recruit adequate follicles, from which the oocytes are retrieved, is called a “poor response.” The incidence of poor ovarian response (POR) in controlled ovarian hyperstimulation (COH) has been reported in 9–24% of intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycles [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

A Flexible Multidose GnRH Antagonist versus a Microdose Flare-Up GnRH Agonist Combined with a Flexible Multidose GnRH Antagonist Protocol in Poor Responders to IVF

Celik

Sütçü

Akpak³

et al. 2015

BioMed Research International

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Objective. To compare the effectiveness of a flexible multidose gonadotropin-releasing hormone (GnRH) antagonist against the effectiveness of a microdose flare-up GnRH agonist combined with a flexible multidose GnRH antagonist protocol in poor responders to in vitro fertilization (IVF). Study Design. A retrospective study in Akdeniz University, Faculty of Medicine, Department of Obstetrics and Gynecology, IVF Center, for 131 poor responders in the intracytoplasmic sperm injection-embryo transfer (ICSI-ET) program between January 2006 and November 2012. The groups were compared to the patients' characteristics, controlled ovarian stimulation (COH) results, and laboratory results. Results. Combination protocol was applied to 46 patients (group 1), and a single protocol was applied to 85 patients (group 2). In group 1, the duration of the treatment was longer and the dose of FSH was higher. The cycle cancellation rate was significantly higher in group 2 (26.1% versus 38.8%). A significant difference was not observed with respect to the number and quality of oocytes and embryos or to the number of embryos transferred. There were no statistically significant differences in the hCG positivity (9.5% versus 9.4%) or the clinical pregnancy rates (7.1% versus 10.6%). Conclusion. The combination protocol does not provide additional efficacy.

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Impact of paternal age on intracytoplasmic sperm injection cycle results

Cited by 3 publications

References 25 publications

Thyroid disorders and fertility

Thyroid disorders and fertility

The Importance of Prolactin Levels in Patients Treated with Cabergoline for the Prevention of OHSS: Is Cabergoline Really Effective in Patients with High Risk of OHSS?

A Flexible Multidose GnRH Antagonist versus a Microdose Flare-Up GnRH Agonist Combined with a Flexible Multidose GnRH Antagonist Protocol in Poor Responders to IVF

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