Impact of partial-volume correction in oncological PET studies: a systematic review and meta-analysis

Cysouw, Matthijs C.F.; Krämer, G.; Schoonmade, Linda J.; Boellaard, Ronald; Vet, Henrica C.W. de; Hoekstra, Otto S.

doi:10.1007/s00259-017-3775-4

Cited by 39 publications

(32 citation statements)

References 47 publications

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“…Despite the large number of PVC methodologies proposed in the literature, explicit corrections for PVE are still far from being fully utilized in clinical routine [178]. This is due to several challenges associated with their automated implementation.…”

Section: Partial Volume Correction In Pet and Spectmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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Section: Partial Volume Correction In Pet and Spectmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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“…DWI and 18 F-FDG-PET/CT). Subgroup analyses was performed for tumors with a MATV > 4.2 ml [22], to avoid bias from partial volume effect in small tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Although some studies use histogram analysis, the predictive accuracy of the combination of DWI and 18 F-FDG-PET/CT for primary tumor and lymph node metastasis was not investigated [20,21]. Finally, quantification of based on robust whole-lesion delineation by multiple independent observers, including partial volume correction [22], was not performed previously [5,16,20,21]. The purpose of this study was to identify predictive pretreatment DWI-and 18 F-FDG-PET/CT-parameters for treatment failure, locoregional recurrence and death in a large cohort of HNSCC-patients treated with (chemo) radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Martens

Noij

Zwezerijnen

et al. 2019

European Journal of Radiology

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Background and purpose: In head and neck squamous cell carcinoma (HNSCC) (chemo)radiotherapy is increasingly used to preserve organ functionality. The purpose of this study was to identify predictive pretreatment DWI-and 18 F-FDG-PET/CT-parameters for treatment failure (TF), locoregional recurrence (LR) and death in HNSCC patients treated by (chemo)radiotherapy. Materials and methods: We retrospectively included 134 histologically proven HNSCC patients treated with (chemo)radiotherapy between 2012-2017. In 58 patients pre-treatment DWI and 18 F-FDG-PET/CT were performed, in 31 patients DWI only and in 45 patients 18 F-FDG-PET/CT only. Primary tumor (PT) and largest lymph node (LN) metastasis were quantitatively assessed for TF, LR and death. Multivariate analysis was performed for 18 F-FDG-PET/CT and DWI separately and thereafter combined. In patients with both imaging modalities, positive and negative predictive value in TF and differences in LR and death, were assessed. Results: Mean follow-up was 25.6 months (interquartile-range; 14.0-37.1 months). Predictors of treatment failure, corrected for TNM-stage and HPV-status, were SUV max-PT , ADC max-PT , total lesion glycolysis (TLG-LN), ADCp20-LN (P = 0.049, P = 0.024, P = 0.031, P = 0.047, respectively). TLG-PT was predictive for LR (P = 0.003). Metabolic active tumor volume (MATV-PT) (P = 0.003), ADC GTV-PT (P < 0.001), ADCSD (P = 0.048) were significant predictors for death. In patients with both imaging modalities SUV max-PT remained predictive for treatment failure (P = 0.049), TLG-LN for LR (P = 0.003) and ADC GTV-PT for death (P < 0.001). Higher predictive value for treatment failure was found for the combination of SUV max-PT and ADC max-PT , compared to either one separately. Conclusion: Both DWI-and 18 F-FDG-PET/CT-parameters appear to have predictive value for treatment failure, locoregional recurrence and death. Combining SUV max-PT and ADC max-PT resulted in better prediction of treatment failure compared to single parameter assessment.

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“…Similarly, it is always possible to compare different ways to combine measurements into a rule, and -given a sufficient sample size -such comparisons can clarify the optimal way to construct such rules. Elements such as cut-off points, definitions of the assignment rule for response/non-response, and combination of PET parameters are easily obtainable, whereas others (time points, modalities, tracers) depend on meticulous planning before the study is conducted.Accurate quantification of small lesions requires partial volume correction in order to prevent underestimation of tumour tracer uptake on PET/CT[172,173]. Taking the perspective that a few lesions may not necessarily represent the overall disease activity in a patient (e.g.…”

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confidence: 99%

PET/CT-Based Response Evaluation in Cancer—a Systematic Review of Design Issues

et al. 2019

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Positron emission tomography/computed tomography (PET/CT) has long been discussed as a promising modality for response evaluation in cancer. When designing respective clinical trials, several design issues have to be addressed, especially the number/timing of PET/CT scans, the approach for quantifying metabolic activity, and the final translation of measurements into a rule. It is unclear how well these issues have been tackled in quest of an optimised use of PET/CT in response evaluation. Medline via Ovid and Science Citation Index via Web of Science were systematically searched for articles from 2015 on cancer patients scanned with PET/CT before and during /after treatment. Reports were categorised as being either developmental or evaluative, i.e. focusing on either the establishment or the evaluation of a rule discriminating responders from non-responders. Of 124 included papers, 112 (90%) were accuracy and/or prognostic studies; the remainder were response-curve studies. No randomised controlled trials were found. Most studies were prospective (62%) and from single centres (85%); median number of patients was 38.5 (range 5-354). Most (69%) of the studies employed only one post-baseline scan. Quantification was mainly based on SUVmax (91%), while change over time was most frequently used to combine measurements into a rule (79%). Half of the reports were categorised as developmental, the other half evaluative. Most development studies assessed only one element (35/62, 56%), most frequently the choice of cutoff points (25/62, 40%). In summary, the majority of studies did not address the essential open issues in establishing PET/CT for response evaluation. Reasonably sized multicentre studies are needed to systematically compare the many different options when using PET/CT for response evaluation.

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Impact of partial-volume correction in oncological PET studies: a systematic review and meta-analysis

Cited by 39 publications

References 47 publications

Hybrid Imaging: Instrumentation and Data Processing

Hybrid Imaging: Instrumentation and Data Processing

Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

PET/CT-Based Response Evaluation in Cancer—a Systematic Review of Design Issues

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