Impact of Partial Body Shielding from Very High Dose Rates on Untargeted Metabolomics in Biodosimetry
Evan L. Pannkuk,
Evagelia C. Laiakis,
Guy Garty
et al.
Abstract:A realistic exposure to ionizing radiation (IR) from an improvised nuclear device will likely include individuals who are partially shielded from the initial blast delivered at a very high dose rate (VHDR). As different tissues have varying levels of radiosensitivity, e.g., hematopoietic vs gastrointestinal tissues, the effects of shielding on radiation biomarkers need to be addressed. Here, we explore how biofluid (urine and serum) metabolite signatures from male and female C57BL/6 mice exposed to VHDR (5−10 … Show more
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