Impact of Parental Adverse Childhood Experiences on Offspring Development in Early Head Start: Parental Adversity and Offspring Development

Miccoli, Antonela; Song, Joanne; Romanowicz, Magdalena; Howie, Flora; Simar, Sandy; Lynch, Brian

doi:10.1177/21501319221084165

Cited by 10 publications

(4 citation statements)

References 40 publications

(68 reference statements)

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“…Child outcomes were categorized into six domains: infant/toddler development, child physical/physiological problems, child mental health problems, child internalizing and externalizing problems, child temperament, and child academic performance. Fifteen studies (22.1%) assessed the effects of parental ACEs on infant and toddler developmental outcomes, mainly including four areas: fine and gross motor skills, speech and language development, cognitive development and problem solving, and social-emotional development (Brittain et al, 2021; Chang et al, 2020; Choi et al, 2017; Coe et al, 2020; Folger et al, 2018; Garon-Bissonnette et al, 2022; McDonnell et al, 2016; Miccoli et al, 2022; Racine et al, 2018; Riggs et al, 2022; Sun et al, 2017; Treat et al, 2019; Tu et al, 2021; Wurster et al, 2020; Zhang et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

Intergenerational Transmission of Parental Adverse Childhood Experiences and Children’s Outcomes: A Scoping Review

Zhang

Mersky

Gruber

et al. 2022

Trauma, Violence, & Abuse

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Adverse childhood experiences (ACEs) are among the leading environmental causes of morbidity and mortality. Extending research on within-generation effects, more recent scholarship has explored between-generation consequences of ACEs. Despite growing interest in the intergenerational effects of parents’ ACEs on children’s outcomes, this line of scholarship has yet to be coalesced into a comprehensive review. The current study is a scoping review on the intergenerational transmission of parental ACEs and children’s outcomes. Ten databases such as PubMed, APA PsycArticles, and Social Work Abstracts were searched. To be included, empirical studies must have been published in English and analyzed associations between a cumulative measure of at least four parental ACEs and children’s outcomes. Sixty-eight studies qualified for the review and, among these, 60 were published in the most recent 5 years (2018–2022). Fifty-one studies had sample sizes smaller than 500, and 55 focused on the effect of maternal ACEs. Nearly all studies demonstrated that parental ACEs could affect children’s outcomes directly or indirectly via mechanisms like maternal mental health problems or parenting-related factors. By scoping the extant literature, this review advances the knowledge base regarding the intergenerational impacts of parental childhood trauma and children’s outcomes. It also reveals methodological limitations that should be addressed in future research to strengthen causal inferences along with practical implications for interventions that aim to interrupt the intergenerational transmission of trauma.

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Section: Resultsmentioning

confidence: 99%

Intergenerational Transmission of Parental Adverse Childhood Experiences and Children’s Outcomes: A Scoping Review

Zhang

Mersky

Gruber

et al. 2022

Trauma, Violence, & Abuse

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“…Our research indicates that respondents aged 15–19 have a higher risk of suicide. This may be due to the fact that older adolescents, compared to their younger counterparts, are closer to puberty, are more emotionally sensitive, and are more likely to have various psychological issues ( 60 ). This study also found that Adolescents living in rural areas are at significantly lower risk of suicide than their urban peers.…”

Section: Discussionmentioning

confidence: 99%

Parent-child attachment mediates the association between parental conflict perceptions and suicide intention: a cross-sectional survey among middle school students in China

Wang,

Chen,

Huang

et al. 2024

Front. Public Health

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IntroductionAdolescent suicide is a prevalent issue globally, with various factors contributing to this phenomenon. This study aimed to investigate these factors and their interrelationships to better understand the causes of adolescent suicide and provide evidence for its prevention.MethodsThis study conducted among middle school students in Liaoning Province, China, from April to May 2016, A cross-sectional survey was administered to 1,028 students aged 10–19, using instruments such as the Behavior Questionnaire-Revised (SBQ-R), Children's Perception of Interparental Conflict Scale (CPIC), and revised version of Inventory of Parent Attachment (IPPA-R).ResultBinary logistic regression analysis revealed that adolescents aged 15–19, adolescents with strong perceptions of parental conflict were at high risk of suicide intention. Adolescents living in rural areas, adolescents with high mother-child attachment, adolescents with high father-child attachment were at low risk of suicide intention. Furthermore, parent-child attachment played a mediating role between two dimensions of parental conflict perception (resolved situations and response effect) and suicide intention.DiscussionThe study concludes that adolescents living in urban areas, older adolescents, adolescents with a high level of parental conflict intensity, and those with low levels of parent-child attachment are at high risk of suicide intention. parent-child attachment played a mediating role between two dimensions of parental conflict perception (resolved situations and response effect) and suicide intention. Interventions aimed at reducing family conflicts and improving parent-child relationships are recommended to decrease the incidence of adolescent suicide.

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“…59,80,81 This is notable because faster early childhood developmental trajectories can be detrimental to long-term health. 82,83 Parental ACEs have also been associated with developmental delays in offspring, 84,85 and lower gestational age and GAA have been associated with increased developmental delays. 86,87 In preterm newborns, accelerated epigenetic aging was associated with impaired neurodevelopmental and behavioral development in newborns and early childhood.…”

Section: Discussionmentioning

confidence: 99%

Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns

Dye,

Alschuler,

et al. 2024

JAMA Netw Open

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ImportanceAdverse childhood experiences (ACEs), potentially traumatic experiences occurring before the age of 18 years, are associated with epigenetic aging later in life and may be transmitted across generations.ObjectiveTo test evidence of the transmission of biological embedding of life experience across generations by analyzing maternal ACEs and epigenetic clocks measured in mothers during pregnancy and in their children at birth.Design, Setting, and ParticipantsFor this cross-sectional study, data from the Accessible Resource for Integrated Epigenomic Studies (ARIES) substudy of the Avon Longitudinal Study of Parents and Children (ALSPAC) were analyzed. The ALSPAC study recruited 14 541 women who gave birth in the Avon Health District in the UK between April 1, 1991, and December 31, 1992. The ARIES substudy comprised 1018 mother-offspring dyads based on the availability of DNA samples profiled in 2014. Epigenetic age was estimated using DNA methylation-based epigenetic clocks (including Horvath, Hannum, GrimAge, PhenoAge, and DunedinPACE) in mothers during pregnancy and the Knight and Bohlin cord blood epigenetic clocks in newborns. Analyses were performed between October 1, 2022, and November 30, 2023.ExposuresA composite measure of maternal ACEs was the primary exposure in both maternal and offspring models; as a secondary analysis, individual ACEs were measured separately. The Edinburgh Postnatal Depression Scale (EPDS) was used to investigate depression during pregnancy as an exposure.Main Outcomes and MeasuresChanges in epigenetic age acceleration (EAA) were investigated as the primary outcome in maternal models during pregnancy. Changes in epigenetic gestational age acceleration (GAA) were the primary outcome in offspring analyses. Linear regression analyses were used to determine the association between maternal ACEs and both outcomes.ResultsThis study included 883 mother-child dyads. The mean (SD) maternal age at delivery was 29.8 (4.3) years. Pregnant women with higher ACE scores exhibited higher GrimAge EAA (β, 0.22 [95% CI, 0.12 to 0.33] years; P &lt; .001). Maternal ACEs were not associated with GAA in newborns using P &lt; .05 as a cutoff to determine statistical significance. Depression was associated with higher GrimAge EAA (β, 0.06 [95% CI, 0.02 to 0.10] years; P = .01) in mothers during pregnancy, but not in newborns, and did not mediate the association between ACEs and EAA.Conclusions and RelevanceThe findings of this study suggest that maternal ACEs may be associated with epigenetic aging later in life, including during pregnancy, supporting a role for maternal ACEs in offspring development and health later in life.

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Impact of Parental Adverse Childhood Experiences on Offspring Development in Early Head Start: Parental Adversity and Offspring Development

Cited by 10 publications

References 40 publications

Intergenerational Transmission of Parental Adverse Childhood Experiences and Children’s Outcomes: A Scoping Review

Intergenerational Transmission of Parental Adverse Childhood Experiences and Children’s Outcomes: A Scoping Review

Parent-child attachment mediates the association between parental conflict perceptions and suicide intention: a cross-sectional survey among middle school students in China

Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns

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