Impact of Osteoporosis on High-Cost Chronic Diseases

Thayer, Sarah; Stolshek, Bradley S.; Rey, Gabriel Gomez; Seare, Jerald

doi:10.1016/j.jval.2013.11.004

Cited by 23 publications

(12 citation statements)

References 25 publications

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“…A possible explanation for this is the influence of musculoskeletal diseases on coexisting chronic diseases. Thayer et al reported that an incident osteoporosis increased the all‐cause total costs of patients with a coexisting disease by 66% to 91% (Thayer et al ., ). Further relevant observations supporting our explanation have been reported by Osiri and Sattayasomboon, who found that the all‐cause and rheumatoid arthritis specific total costs of rheumatoid arthritis patients were raised by 100% (all‐cause total costs) and 25% (rheumatoid arthritis specific total costs), respectively, by the existence of comorbid conditions (Osiri and Sattayasomboon, ).…”

Section: Discussionmentioning

confidence: 97%

Analysis of Health Care Costs in Elderly Patients with Multiple Chronic Conditions Using a Finite Mixture of Generalized Linear Models

et al. 2016

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In this paper we analysed healthcare costs in a sample of elderly patients suffering from multimorbidity. On the one hand, multimorbid individuals consume a disproportionally large share of healthcare resources. On the other hand, the patient specific number and combination of co-occurring single diseases result in inhomogeneous data leading to biased estimates when using traditional regression techniques. Therefore, we applied a mixture of regressions in order to control for unobserved heterogeneity focussing on the identification of multimorbidity patterns. We used a subsample of N = 1050 patients from a multicentre prospective cohort study of randomly selected multimorbid primary care patients aged 65 to 85 years in Germany (ISRCTN 89818205) who completed a detailed questionnaire on healthcare utilization during the 6-month period preceding the interview. Disease combinations of 1047 were included. We detected four different groups of patients with regard to total costs. These groups corresponded largely to findings from the epidemiological literature. The effect of the presence of an additional disease on costs differed between groups. Moreover, two diametrically opposed cost trends were detected with respect to the number of co-occurring diseases. While in one group costs increased with the number of co-occurring diseases, in a second group cost tended to decrease. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 97%

Analysis of Health Care Costs in Elderly Patients with Multiple Chronic Conditions Using a Finite Mixture of Generalized Linear Models

et al. 2016

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“…It has been estimated that 87% of all fractures in the elderly are the result of a fall and 5–10% of all falls result in a fracture [ 466 , 467 , 468 ]. Among 494,160 patients aged ≥50 years with OP, 9% had only OP, while the rest had also chronic diseases, including CVD (54%), DM (8%), depression (4%), COPD (1%), with two or more diseases in 24% [ 469 ]; the HPI status in this study has not been reported.…”

Section: Hpi-associated Chronic Extra-gastroduodenal Diseases Medmentioning

confidence: 98%

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Fisher

Smith

2020

JCM

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Osteoporosis (OP) and osteoporotic fractures (OFs) are common multifactorial and heterogenic disorders of increasing incidence. Helicobacter pylori (H.p.) colonizes the stomach approximately in half of the world’s population, causes gastroduodenal diseases and is prevalent in numerous extra-digestive diseases known to be associated with OP/OF. The studies regarding relationship between H.p. infection (HPI) and OP/OFs are inconsistent. The current review summarizes the relevant literature on the potential role of HPI in OP, falls and OFs and highlights the reasons for controversies in the publications. In the first section, after a brief overview of HPI biological features, we analyze the studies evaluating the association of HPI and bone status. The second part includes data on the prevalence of OP/OFs in HPI-induced gastroduodenal diseases (peptic ulcer, chronic/atrophic gastritis and cancer) and the effects of acid-suppressive drugs. In the next section, we discuss the possible contribution of HPI-associated extra-digestive diseases and medications to OP/OF, focusing on conditions affecting both bone homeostasis and predisposing to falls. In the last section, we describe clinical implications of accumulated data on HPI as a co-factor of OP/OF and present a feasible five-step algorithm for OP/OF risk assessment and management in regard to HPI, emphasizing the importance of an integrative (but differentiated) holistic approach. Increased awareness about the consequences of HPI linked to OP/OF can aid early detection and management. Further research on the HPI–OP/OF relationship is needed to close current knowledge gaps and improve clinical management of both OP/OF and HPI-related disorders.

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“…Because smoking is a major risk factor for chronic diseases, which may be seriously aggravated by concurrent osteoporosis (9), better understanding the interaction of smoking and calcium intake on bone health would be very important. However, large-scale epidemiological replications of this effect modification are lacking.…”

mentioning

confidence: 99%

Smoking as an Effect Modifier of the Association of Calcium Intake With Bone Mineral Density

Breitling

2015

The Journal of Clinical Endocrinology & Metabolism

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Impact of Osteoporosis on High-Cost Chronic Diseases

Abstract: The burden of osteoporosis in patients with CD is significant, particularly for patients with newly diagnosed osteoporosis.

Cited by 23 publications

References 25 publications

Analysis of Health Care Costs in Elderly Patients with Multiple Chronic Conditions Using a Finite Mixture of Generalized Linear Models

Analysis of Health Care Costs in Elderly Patients with Multiple Chronic Conditions Using a Finite Mixture of Generalized Linear Models

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Smoking as an Effect Modifier of the Association of Calcium Intake With Bone Mineral Density

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