Impact of osteopenia on surgical and oncological outcomes in patients with pancreatic cancer

Abe, Kyohei; Furukawa, Kenei; Okamoto, Tomoyoshi; Matsumoto, Michinori; Futagawa, Yasuro; Haruki, Koichiro; Shirai, Yoshio; Ikegami, Toru

doi:10.1007/s10147-021-01986-w

Cited by 16 publications

(6 citation statements)

References 30 publications

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“…In fact, there are several reports showing the poor prognostic impact of osteopenia in hepatocellular carcinoma, cholangiocarcinoma, pancreatic cancer, and esophageal cancer. [13][14][15][16][17][18] With regard to CRC, there are only a few reports with small cohort sizes. 12,13 This study aimed to assess the impact of preoperative osteopenia on the recurrence and survival of patients with CRC.…”

Section: E1226mentioning

confidence: 99%

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The Prognostic Impact of Preoperative Osteopenia in Patients With Colorectal Cancer

Kato,

Seishima,

Mizuno

et al. 2023

Diseases of the Colon &Amp; Rectum

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BACKGROUND: Osteopenia, a condition in which bone mineral density is lower than normal, is a noted risk factor that leads to a shortened healthy life expectancy. OBJECTIVE: This study aimed to investigate the prognostic impact of preoperative osteopenia in colorectal cancer patients. DESIGN: This was a retrospective study. SETTING: This study was conducted at a university hospital. PATIENTS: A total of 1,086 stage I-III colorectal cancer patients who underwent curative resection. MAIN OUTCOME MEASURES: Osteopenia was evaluated with computed tomography imaging. Overall survival, disease-specific survival, and recurrence-free survival were the primary endpoints. RESULTS: Osteopenia was identified in 300 patients (27.6%). Compared with the non-osteopenia group, the 5-year overall survival (74.0% vs. 93.4%, p < 0.001), disease-specific survival (81.6% vs. 97.2%, p < 0.001), and recurrence-free survival rates (57.1% vs. 88.3%, p < 0.001) were significantly lower in the osteopenia group. Multivariate analyses showed that preoperative osteopenia was significantly associated with worse overall survival (HR: 4.135; 95% CI: 2.963-5.770; p < 0.001), disease-specific survival (HR: 7.673; 95% CI: 4.646-12.675; p < 0.001), and recurrence-free survival (HR: 5.039; 95% CI: 3.811-6.662; p < 0.001). The prognosis of the osteopenia group was poorer than that of the non-osteopenia group in every stage: 5-year overall survival (stage I: 89.4% vs. 96.9%, p = 0.028; stage II: 76.5% vs. 91.9%, p < 0.001; stage III: 56.4% vs. 90.8%, p < 0.001) and 5-year RFS (stage I: 85.4% vs. 96.6%, p = 0.002; stage II: 62.0% vs. 86.5%, p < 0.001; stage III: 26.4% vs. 80.0%, p < 0.001). LIMITATIONS: The main limitations are retrospective single-institutional feature, and races of study population. CONCLUSION: Preoperative osteopenia could be a strong predictive marker for long-term prognosis in colorectal cancer regardless of stage.

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Section: E1226mentioning

confidence: 99%

mentioning

confidence: 99%

The Prognostic Impact of Preoperative Osteopenia in Patients With Colorectal Cancer

Kato,

Seishima,

Mizuno

et al. 2023

Diseases of the Colon &Amp; Rectum

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“…The immune-nutritional prognostic factors were also assessed using the total lymphocyte count (TLC), lymphocyte c-reactive protein (CRP) ratio (LCR) [15], neutrophil lymphocyte ratio (NLR) [16], modi ed Glasgow prognostic score (mGPS) [17], and prognostic nutritional index (PNI) [18]. The de nition of sarcopenia and osteopenia was described previously [19]. The frailty assessment was described previously [8,9].…”

Section: Patientsmentioning

confidence: 99%

Prognostic impact of frailty after gastrectomy in elderly gastric cancer patients

Nishi

Shimada

Yoshikawa

et al. 2022

Preprint

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Background Frailty plays a crucial role in cancer patients who have received surgery in this recent aging society. We aimed to investigate frailty as a prognostic factor in elderly gastric cancer (GC) patients who underwent curative gastrectomy. Methods In this study, we analyzed 86 elderly (over 75 years old) GC patients who underwent curative gastrectomy. Frailty was defined as clinical frailty scale score of ≥ 4. Patients were assigned to two groups; frailty group (n = 29) and no-frailty group (n = 57). Clinicopathological values, including comorbidity, immune-nutritional score, and long-term outcomes, were compared between the frailty and no-frailty groups.Results The frailty group displayed a positive correlation with a previous history of symptomatic stroke (p < 0.05). Moreover, the overall survival (OS) rate was significantly poorer in the frailty group (5-yr OS; frailty group 52.09% vs. no-frailty group 72.02%, p < 0.05). By contrast, there were no significant differences in both the cancer-specific survival (5-yr CSS; frailty group 82.33% vs. no-frailty group 89.32%, p = 0.14) and the disease-free survival (5-yr DFS; frailty group 74.68% vs. no-frailty group 86.91%, p = 0.33). Finally, frailty, differentiation, surgical procedure and the lymphocyte c-reactive protein ratio were identified among clinicopathological factors as independent prognostic factors for OS in multivariate analysis. Conclusion We identified the clinical impact of frailty as an independent prognostic factor for elderly GC patients who underwent gastrectomy.

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“…Sharma et al recently found that low BMD, a surrogate marker for bone loss, is independently associated with early deconditioning markers that precede sarcopenia [ 10 ]. Reports associated with several types of malignancies showed that osteopenia is associated with decreased survival [ 6 , 11 , 12 , 13 ]. Bone loss with age was reported to be more common in females as a consequence of post-menopausal findings.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Bone Loss Predicts Decreased Survival Associated with Microvascular Invasion after Resection of Hepatocellular Carcinoma

Ishida,

Miki,

Sakuma

et al. 2024

Cancers

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Background: Osteopenia is a well-known risk factor for survival in patients with hepatocellular carcinoma; however, it is unclear whether osteopenia can apply to both genders and how osteopenia is associated with cancer progression. The aim of this study was to elucidate whether osteopenia predicts reduced survival in regression models in both genders and whether osteopenia is associated with the pathological factors associated with reduced survival. Methods: This study included 188 consecutive patients who underwent hepatectomy. Bone mineral density was assessed using computed tomography (CT) scan images taken within 3 months before surgery. Non-contrast CT scan images at the level of the 11th thoracic vertebra were used. The cutoff value of osteopenia was calculated using a threshold value of 160 Hounsfield units. Overall survival (OS) curves and recurrence-free survival (RFS) were constructed using the Kaplan–Meier method, as was a log-rank test for survival. The hazard ratio and 95% confidence interval for overall survival were calculated using Cox’s proportional hazard model. Results: In the regression analysis, age predicted bone mineral density. The association in females was greater than that in males. The OS and RFS of osteopenia patients were shorter than those for non-osteopenia patients. According to univariate and multivariate analyses, osteopenia was an independent risk factor for OS and RFS. The sole pathological factor associated with osteopenia was microvascular portal vein invasion. Conclusion: Models suggest that osteopenia may predict decreased OS and RFS in patients undergoing resection of hepatocellular carcinoma due to the mechanisms mediated via microvascular portal vein invasion.

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Impact of osteopenia on surgical and oncological outcomes in patients with pancreatic cancer

Cited by 16 publications

References 30 publications

The Prognostic Impact of Preoperative Osteopenia in Patients With Colorectal Cancer

The Prognostic Impact of Preoperative Osteopenia in Patients With Colorectal Cancer

Prognostic impact of frailty after gastrectomy in elderly gastric cancer patients

Preoperative Bone Loss Predicts Decreased Survival Associated with Microvascular Invasion after Resection of Hepatocellular Carcinoma

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