Impact of OSA treatment success on changes in hypertension and obesity: A retrospective cohort study

Shanmugam, Akash; Binney, Zachary; Voyles, Courtney B.; Bouldin, Emerson

doi:10.1016/j.sleep.2022.10.023

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…Thus, measuring BP in children could be considered a good CV risk marker. The pathophysiology of HBP in OSA depends on various factors, apart from increased sympathetic tone, such as peripheral vasoconstriction, increased renin–angiotensin–aldosterone activity, and proinflammatory responses [ 40 , 78 ], causing persistent increases in vascular resistance and altering BP [ 79 ]. Related to BP, it has been demonstrated that OSA in adults is a risk factor for developing a nondipping profile [ 80 , 81 ], produced when nocturnal BP decreases less than 10% of daytime BP.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Solano-Pérez,

Coso,

Castillo-García

et al. 2023

Biomedicines

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Obstructive sleep apnea (OSA) in children is a prevalent, but still, today, underdiagnosed illness, which consists of repetitive episodes of upper airway obstruction during sleep with important repercussions for sleep quality. OSA has relevant consequences in the pediatric population, mainly in the metabolic, cardiovascular (CV), and neurological spheres. However, contrary to adults, advances in diagnostic and therapeutic management have been scarce in the last few years despite the increasing scientific evidence of the deleterious consequences of pediatric OSA. The problem of underdiagnosis and the lack of response to treatment in some groups make an update to the management of OSA in children necessary. Probably, the heterogeneity of OSA is not well represented by the classical clinical presentation and severity parameters (apnea/hypopnea index (AHI)), and new strategies are required. A specific and consensus definition should be established. Additionally, the role of simplified methods in the diagnosis algorithm should be considered. Finally, the search for new biomarkers for risk stratification is needed in this population. In conclusion, new paradigms based on personalized medicine should be implemented in this population.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Solano-Pérez,

Coso,

Castillo-García

et al. 2023

Biomedicines

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“…The patients with BMI less than 27.5 had higher improvements in subjective outcomes including snoring VAS score and ESS, but the AHI improvement was higher in patients with BMI ≥ 27.5. Possible explanation by previous literature was fat deposits in the neck region resulting in upper airway collapse during sleep, 29 which was hard to be corrected and could possess negative sleep impact even after receiving surgical treatment (since obesity may not be the major and direct target of general sleep therapies 30 ).…”

Section: Discussionmentioning

confidence: 99%

Minimally invasive, single‐stage, multilevel surgery for obstructive sleep apnoea: A systematic review and meta‐analysis

Rahavi‐Ezabadi,

Su,

Wang

et al. 2023

Clinical Otolaryngology

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ObjectivesMinimally invasive, single‐staged multilevel surgery (MISS MLS) could be an optimal treatment for selected patients with obstructive sleep apnea (OSA). We aim to systematically review the efficacy of MISS MLS for patients with OSA, as well as the clinical outcomes and possible complications in OSA patients before and after MISS MLS.Design and settingSystematic review and meta‐analysis. Six databases were searched, and the PRISMA guideline was followed.ParticipantsPatients with OSA receiving MISS MLS.Main outcome measuresThe random‐effects model was adopted for the statistical synthesis. The percentage and 95% confidence interval (CI) were adopted as the effect measurements of MISS MLS for OSA. Subgroup analyses and sensitivity analyses were also performed to identify the heterogeneity among the studies.ResultsThere were initially 154 articles for identification. Eventually, six studies with a total of 848 OSA patients completely met the inclusion criteria and were further enrolled for analysis. The pooled analysis showed statistically significant lower AHI (apnea/hypopnea index, /hr.; mean difference: −8.931, 95% CI: −11.591 to −6.271, I2 = 87.4%), ESS (mean difference: −2.947, 95% CI: −4.465 to −1.429, I2 = 94.9%), and snoring severity with 0‐10 visual analog scale after surgery (mean difference: −4.966, 95% CI: −5.804 to −4.128, I2 = 96.4%). The success rate was 46% in mild/moderate OSA; however, 18% in severe OSA. There were no major complications occurred.ConclusionsThe acceptable surgical outcomes, esp. in mild/moderate OSA, and rare complications are the major advantages of MISS MLS. The evidence of this study could aid the decision making in selecting suitable treatment programs for OSA patients.

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Impact of OSA treatment success on changes in hypertension and obesity: A retrospective cohort study

Cited by 2 publications

References 40 publications

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Minimally invasive, single‐stage, multilevel surgery for obstructive sleep apnoea: A systematic review and meta‐analysis

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