Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D

Yang, Chen; Albietz, Julie; Harkin, Damien G.; Kimlin, Michael G.; Schmid, Katrina L.

doi:10.1016/j.clae.2017.09.007

Cited by 47 publications

(30 citation statements)

References 42 publications

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“…Bae and co-authors evaluated the efficacy of vitamin D supplementation in patients with DED refractory to conventional treatment who presented vitamin D deficiency, and reported a significant improvement of Schirmer test, break-up time, corneal staining, eyelid margin hyperemia and subjective discomfort symptoms [91]. In agreement with these results, Yang and co-workers observed a significant improvement of dry eye symptoms and corneal staining after 2 months of vitamin D supplementation [92] Furthermore, the therapeutic effect of tear substitutes depends on serum vitamin D levels, and oral supplementation has shown to synergistically enhance their efficacy [93].…”

Section: Vitamin Dmentioning

confidence: 69%

The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases

et al. 2020

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Dry eye disease (DED) is a multifactorial disease of the ocular surface system whose chore mechanisms are tear film instability, inflammation, tear hyperosmolarity and epithelial damage. In recent years, novel therapies specifically targeting inflammation and oxidative stress are being investigated and used in this field. Therefore, an increasing body of evidence supporting the possible role of different micronutrients and nutraceutical products for the treatment of ocular surface diseases is now available. In the present review, we analyzed in detail the effects on ocular surface of omega-3 fatty acids, vitamins A, B12, C, D, selenium, curcumin and flavonoids. Among these, the efficacy of omega-3 fatty acid supplementation in ameliorating DED signs and symptoms is supported by robust scientific evidence. Further long-term clinical trials are warranted to confirm the safety and efficacy of the supplementation of the other micronutrients and nutraceuticals.

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Section: Vitamin Dmentioning

confidence: 69%

The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases

et al. 2020

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“…This included not only multivitamin combinations, but also vitamin D preparations which accounted for the majority of vitamin use in our study population [32]. Vitamin D supplementation has been found to improve dry eye symptoms including tear quality and ocular surface conditions [33], particularly in those with low vitamin D levels and who have symptoms refractory to conventional treatment [34]. Further research should thus investigate the temporal association between vitamin use and dry eyes in longitudinal studies.…”

Section: Discussionmentioning

confidence: 99%

Dry Eyes, Ocular Lubricants, and Use of Systemic Medications Known or Suspected to Cause Dry Eyes in Residents of Aged Care Services

Aljeaidi

Keen

Bell

et al. 2020

IJERPH

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Ocular issues are common, burdensome, and under-researched among residents of aged care services. This study aims to investigate the prevalence of dry eyes or use of ocular lubricants among residents, and the possible association with systemic medications known or suspected to cause dry eyes. A cross-sectional study of 383 residents of six aged care services in South Australia was conducted. Data were extracted from participants’ medical histories, medication charts, and validated assessments. The main exposure was systemic medications known to cause, contribute to, or aggravate dry eyes. The primary outcome was documented dry eyes or regular administration of ocular lubricants. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between systemic medications and dry eyes/use of ocular lubricants. Dry eyes were documented for 53 (13.8%) residents and 98 (25.6%) residents were administered ocular lubricants. Overall, 116 (30.3%) residents had documented dry eyes/used ocular lubricants. Of these, half (n = 58) were taking a medication known to cause, contribute to, or aggravate dry eyes. Taking one or more medications listed as known to cause dry eyes was associated with having dry eyes/use of ocular lubricants (OR 1.83, 95% CI 1.15–2.94). In sub-analyses, no individual medication was associated with dry eyes/use of ocular lubricants. Dry eyes and use of ocular lubricants are common in residential aged care. Our hypothesis generating findings suggest the need for further research into the clinical significance of systemic medications as a possible cause of dry eyes.

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“…19 Study by Chih-Huang Yang et al in 2018 also found Vitamin D supplement increased the vitamin D levels, and improved dry eye symptoms, the tear quality and ocular surface conditions. 20 Demirci, Goktug et al, 2018 concluded that vitamin D deficiency is associated with tear hyperosmolarity and tear film dysfunction. 21 Dry eye disease is a grossly under-diagnosed entity.…”

Section: Discussionmentioning

confidence: 99%

Study of Association of Dry Eye Syndrome with Low Vitamin D Levels and Effect of Supplementation

Nanda¹,

Pattnaik²,

Khuntia³

2019

jebmh

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BACKGROUND Dry eye disease, though common, is a frequently under-recognized clinical state whose aetiology and management are challenging. Many external and internal factors have been studied, which affects the stability of tear film. This study aims at determining the association between serum 25(OH) Vitamin D and Dry Eye Syndrome (DES) incidence and how treatment with supplementation affects the outcome. METHODS This is a case-control study with 75 DES cases and 75 healthy controls. The main parameter to detect the level of vitamin D was Serum 25(OH)D. The DES parameters included ocular surface disease index (OSDI) scales, tear film breakup time (TBUT), fluorescein staining score (FSS), eyelid margin hyperemia, tear secretion test and Schirmer test. The differences in each parameter between case and control groups were detected and the association of serum 25(OH) D and DES parameter were studied. Deficient patients were given vitamin D-supplementation. The DES parameters were followed up after 8 and 12 weeks. Comparison was done between pre-treatment and post-treatment values. RESULTS 25(OH) D levels were lower in patients with DES than in healthy controls. Vitamin D deficiency was more common in the DES cases. Parameters were measured before treatment and after 8 and 12 weeks of vitamin D supplementation. Mean serum 25(OH)D level was 10.52 ± 4.61 ng/mL. TBUT, and tear secretion test showed an improvement at 8 and 12 weeks after vitamin D supplementation compared to pre-treatment values (p <0.05 for all, paired t-test). Eyelid margin hyperemia and the severity of symptoms showed improvement at 8 and 12 weeks after vitamin D supplementation (p <0.05). CONCLUSIONS A significant association between serum 25(OH)D level and DES incidence was detected in this study. It was found that vitamin D deficiency decreases the TBUT and Schirmer test values. Vitamin D supplementation promoted tear secretion, reduced tear instability, and reduced inflammation at the ocular surface and eyelid margin. Considering the effect of vitamin D on the immune system, it could be assumed that the immuno-regulatory effect of vitamin D might be influencing the development of DES.

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Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D

Cited by 47 publications

References 42 publications

The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases

The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases

Dry Eyes, Ocular Lubricants, and Use of Systemic Medications Known or Suspected to Cause Dry Eyes in Residents of Aged Care Services

Study of Association of Dry Eye Syndrome with Low Vitamin D Levels and Effect of Supplementation

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