Impact of oral vitamin C on histamine levels and seasickness

Jarisch, Reinhart; Weyer, Dirk; Ehlert, Elias; Koch, C; Pinkowski, E.; Jung, Pa Jong; Kähler, Wataru; Girgensohn, R.; Kowalski, Jan; Weisser, Burkhard; Koch, Alexia

doi:10.3233/ves-140509

Cited by 10 publications

(10 citation statements)

References 12 publications

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“…A protein‐predominant beverage taken 5 or 30 min before optokinetic stimulation was found to be effective in suppressing gastric tachyarrhythmia and MS symptoms . A recent double‐blind, placebo‐controlled crossover study found that vitamin C was effective in suppressing symptoms of seasickness, particularly in youngsters .…”

Section: Nonpharmacological Countermeasuresmentioning

confidence: 99%

Motion Sickness: Current Knowledge and Recent Advance

et al. 2015

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Motion sickness (MS) is a common physiological response to real or virtual motion. Numerous studies have investigated the neurobiological mechanism and the control measures of MS. This review summarizes the current knowledge about pathogenesis and pathophysiology, prediction, evaluation, and countermeasures of MS. The sensory conflict hypothesis is the most widely accepted theory for MS. Both the hippocampus and vestibular cortex might play a role in forming internal model. The pathophysiology focuses on the visceral afference, thermoregulation and MS-related neuroendocrine. Single-nucleotide polymorphisms (SNPs) in some genes and epigenetic modulation might contribute to MS susceptibility and habituation. Questionnaires, heart rate variability (HRV) and electrogastrogram (EGG) are useful for diagnosing and evaluating MS. We also list MS medications to guide clinical practice. Repeated real motion exposure and combined visual-vestibular interaction training accelerate the progress of habituation. Behavioral and dietary countermeasures, as well as physiotherapy, are also effective in alleviating MS symptoms.

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Section: Nonpharmacological Countermeasuresmentioning

confidence: 99%

Motion Sickness: Current Knowledge and Recent Advance

et al. 2015

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“…It has been documented that the residents of the Samoa islets consumed one or two mangoes prior to their sailing trips to prevent sea sickness [ 123 ]. This could be attributed to the high levels of polyphenols [ 124 ] and ascorbic acid (vitamin C) in mangoes [ 124 , 125 ].…”

Section: Interventions For Mitigating Motion Sicknessmentioning

confidence: 99%

Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review

et al. 2023

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The mismatch in signals perceived by the vestibular and visual systems to the brain, also referred to as motion sickness syndrome, has been diagnosed as a challenging condition with no clear mechanism. Motion sickness causes undesirable symptoms during travel and in virtual environments that affect people negatively. Treatments are directed toward reducing conflicting sensory inputs, accelerating the process of adaptation, and controlling nausea and vomiting. The long-term use of current medications is often hindered by their various side effects. Hence, this review aims to identify non-pharmacological strategies that can be employed to reduce or prevent motion sickness in both real and virtual environments. Research suggests that activation of the parasympathetic nervous system using pleasant music and diaphragmatic breathing can help alleviate symptoms of motion sickness. Certain micronutrients such as hesperidin, menthol, vitamin C, and gingerol were shown to have a positive impact on alleviating motion sickness. However, the effects of macronutrients are more complex and can be influenced by factors such as the food matrix and composition. Herbal dietary formulations such as Tianxian and Tamzin were shown to be as effective as medications. Therefore, nutritional interventions along with behavioral countermeasures could be considered as inexpensive and simple approaches to mitigate motion sickness. Finally, we discussed possible mechanisms underlying these interventions, the most significant limitations, research gaps, and future research directions for motion sickness.

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“…Vitamin C was used as an adjuvant to correct the HI. A daily dose of 300–500 mg enhanced histamine degradation and inhibited mast cell degranulation [ 127 ]. Natural flavonoids (fisetin, kaempferol, quercetin, rutin, and luteolin) and the active alkaloid berberine inhibit mast cell degranulation in vitro [ 128 ].…”

Section: Principles Of Treatment For Histamine Intolerancementioning

confidence: 99%

Food Intolerance: The Role of Histamine

et al. 2021

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Histamine is a natural amine derived from L-histidine. Although it seems that our knowledge about this molecule is wide and diverse, the importance of histamine in many regulatory processes is still enigmatic. The interplay between different types of histamine receptors and the compound may cause ample effects, including histamine intoxication and so-called histamine intolerance or non-allergic food intolerance, leading to disturbances in immune regulation, manifestation of gastroenterological symptoms, and neurological diseases. Most cases of clinical manifestations of histamine intolerance are non-specific due to tissue-specific distribution of different histamine receptors and the lack of reproducible and reliable diagnostic markers. The diagnosis of histamine intolerance is fraught with difficulties, in addition to challenges related to the selection of a proper treatment strategy, the regular course of recovery, and reduced amelioration of chronic symptoms due to inappropriate treatment prescription. Here, we reviewed a history of histamine uptake starting from the current knowledge about its degradation and the prevalence of histamine precursors in daily food, and continuing with the receptor interactions after entering and the impacts on the immune, central nervous, and gastrointestinal systems. The purpose of this review is to build an extraordinarily specific method of histamine cycle assessment in regard to non-allergic intolerance and its possible dire consequences that can be suffered.

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Impact of oral vitamin C on histamine levels and seasickness

Cited by 10 publications

References 12 publications

Motion Sickness: Current Knowledge and Recent Advance

Motion Sickness: Current Knowledge and Recent Advance

Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review

Food Intolerance: The Role of Histamine

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