Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: An integrated backscatter intravascular ultrasound study

Amano, Tetsuya; Matsubara, Tatsuaki; Uetani, Tadayuki; Kato, Masataka; Kato, Bunichi; Yoshida, Tomohiro; Harada, Ken; Kumagai, S.; Kunimura, Ayako; Shinbo, Yusaku; Kitagawa, Kakuya; Ishii, Hideki; Murohara, Toyoaki

doi:10.1016/j.atherosclerosis.2011.05.030

Cited by 75 publications

(55 citation statements)

References 29 publications

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“…An inflammation partially regulated by eicosanoids was produced from PUFA. Notably, the effects of such eicosanoids can be accelerated by competition between AA (ω-6) and EPA (ω-3) (15)(16)(17). Therefore, the present results seemed to be reasonable.…”

Section: Discussionsupporting

confidence: 60%

“…Vulnerable coronary plaques are usually highly inflamed, and have a large lipid-core (7). We have reported the association of a low serum content of ω-3 PUFA with lipid-rich coronary plaque using integrated backscatter intravascular ultrasound (15). In the present study, patients with a lower plasma EPA/AA ratio tended to have higher levels of high-sensitivity CRP which is a potent predictor for future CVD (14).…”

Section: Discussionsupporting

confidence: 46%

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Association of Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acid Ratio with Complexity of Coronary Artery Lesion

et al. 2012

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Objective Eicosapentaenoic acid (EPA) of the omega-3 polyunsaturated fatty acids (ω-3 PUFA) family plays important roles in the prevention of cardiovascular disease (CVD), while, arachidonic acid (AA) of the ω-6 PUFA family promotes inflammatory and prothrombotic influences. The complexity of coronary lesions represents the vulnerability of patients. The aim of this study was to investigate the association between the plasma EPA/AA ratio and the prevalence of complex coronary lesion morphology. Methods This study consisted of 206 consecutive patients with stable angina pectoris (sAP). Each coronary lesion was determined either as complex or simple based on angiographic findings. To examine the plasma fatty acid level, blood samples were obtained. Patients were divided into three groups according to the obtained plasma EPA/AA ratio: the highest tertile, n=67, the 2nd tertile, n=70, or the lowest tertile, n=69. Results A higher incidence of complex coronary lesion was obtained from patients with a lower plasma EPA/AA ratio [43 (62%) vs. 31 (44%) vs. 25 (37%), p=0.011]. High-sensitivity CRP levels and a low plasma EPA/AA ratio could independently predict the prevalence of complex coronary lesions on multivariate logistic regression analysis [odds ratio 1.83 (95%CI 1.03-3.25), p=0.038 and odds ratio 2.10 (95%CI 1.11-3.94), p=0.02)]. Conclusion In patients with sAP, a low plasma EPA/AA ratio was significantly associated with a high prevalence of complex coronary lesions.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionsupporting

confidence: 46%

Association of Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acid Ratio with Complexity of Coronary Artery Lesion

et al. 2012

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“…An integrated backscatter intravascular ultrasound analysis showed that the serum content of EPA correlates inversely with the % lipid volume (r 0.265, p 0.004) and positively with the % fibrous volume (r 0.268, p 0.004) in coronary plaques 19) . Additionally, a coronary computed tomography (CT) study demonstrated a low serum EPA level to be independently associated with high-risk plaque (a minimum CT density of 39 HU and remodeling index of 1.05) for ACS (HR 2.47, 95% CI 1.27-4.92; p 0.008) 20) , and a study using ultrasound imaging and laser-Doppler flowmetry revealed that six weeks of supplementation with EPA improved the macrovascular and microvascular function relative to that achieved with a placebo (maximum decrease in flow-mediated dilatation of the brachial artery 13%, and maximum increase in reactive hyperemia of the hand 27%) 21) .…”

Section: Imaging Studies Conducted Under Epa Treatmentmentioning

confidence: 98%

Impact of Eicosapentaenoic Acid Treatment on the Fibrous Cap Thickness in Patients with Coronary Atherosclerotic Plaque: An Optical Coherence Tomography Study

Yamano

Kubo

Shiono

et al. 2015

J Atheroscler Thromb

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“…Amano, et al showed that low levels of n-3 PUFAs are associated with lipid-rich plaques detected by using integrated backscatter intravascular ultrasound, 13) and Urabe, et al reported that a low serum EPA level is associated with the presence and extent of high-risk plaques detected by coronary computed tomography angiography in patients receiving statin therapy. 14) However, little is known about the relationship between n-3 PUFAs and coronary atherosclerosis in patients with acute coronary syndrome, especially in patients with ST elevation myocardial infarction (STEMI).…”

Section: Editorial P837mentioning

confidence: 99%

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

et al. 2017

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SummaryA relationship between serum polyunsaturated fatty acids (PUFAs) and cardiovascular disease has been reported; however, the existence of a relationship between serum PUFAs and extent of vessel disease (VD) in patients with ST elevation myocardial infarction (STEMI) remains unclear.Between July 2011 and June 2015, 866 consecutive STEMI patients underwent emergent percutaneous coronary intervention, 507 of whom were enrolled and classified into three groups according to the initial angiograms: 1VD, 294 patients; 2VD, 110 patients; and 3VD/left main trunk disease (LMTD), 103 patients. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, and other laboratory data during hospitalization were evaluated.The serum EPA level in the 3VD/LMTD group was significantly lower than that in the 1VD group (55.5 ± 22.1 versus 66.2 ± 28.7, P = 0.002) and was slightly lower than that in the 2VD group (55.5 ± 22.1 versus 65.2 ± 28.9, P = 0.0167). Multivariate adjustment analysis revealed that age !70 years (odds ratio, 1.72; 95% confidence interval, 1.03-2.89; P = 0.038) and a low serum EPA level (odds ratio, 0.98; 95% confidence interval, 0.99-1.00; P = 0.023) were independent risk factors for 3VD/LMTD, while a low serum DHA level was not.A low serum EPA level may be more strongly related than a low serum DHA level to the extent of VD in STEMI patients. Age !70 years and a low serum EPA level may be independent risk factors for 3VD/LMTD.(Int Heart J 2017; 58: 868-873) Key words: Eicosapentaenoic acid, Docosahexaenoic acid, Mulivessel disease, Acute coronary syndrome, Cardiovascular disease A n association between fish intake and risk of cardiovascular disease has been demonstrated in several epidemiological studies and clinical trials.

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Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: An integrated backscatter intravascular ultrasound study

Cited by 75 publications

References 29 publications

Association of Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acid Ratio with Complexity of Coronary Artery Lesion

Association of Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acid Ratio with Complexity of Coronary Artery Lesion

Impact of Eicosapentaenoic Acid Treatment on the Fibrous Cap Thickness in Patients with Coronary Atherosclerotic Plaque: An Optical Coherence Tomography Study

Relationship between n-3 Polyunsaturated Fatty Acids and Extent of Vessel Disease in Patients with ST Elevation Myocardial Infarction

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