Impact of old Schistosomiasis infection on the use of transient elastography (Fibroscan) for staging of fibrosis in chronic HCV patients

Ramzy, Iman; Elsharkawy, Aisha; Fouad, Rabab; Hafez, Hassan A.; Raziky, Maissa El; El-Akel, Wafaa; El-Sayed, Mohammad; Khattab, H. M.; Shehata, Mohamed; Elsharkawy, Marwa; Radwan, Amr; Esmat, Gamal

doi:10.1016/j.actatropica.2017.08.019

Cited by 6 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, schistosomiasis was excluded based on history, antischistosomal antibody negativity, and the absence of significant periportal fibrosis in ultrasound examination. [ 36 ]…”

Section: Discussionmentioning

confidence: 99%

Liver stiffness measurement and spleen diameter as predictors for the presence of esophageal varices in chronic hepatitis C patients

et al. 2017

View full text Add to dashboard Cite

Although it is an invasive and unpleasant procedure, esophagogastroduodenoscopy (EGD) is still the gold standard for esophageal varices (EV) detection. The aim of this study was to investigate liver stiffness measurement (LSM) and spleen diameter as simple noninvasive tools for EV prediction in chronic hepatitis C patients (CHC).A total of 123 Egyptian patients with CHC have been included and were classified based on screening EGD result into 2 groups; group A (without EV) and group B (with EV). Group (B) was subclassified according to EV grade into 4 subgroups: (B1, grade I), (B2, grade II), (B3, grade III), and (B4, grade IV). LSM was taken for each patient on the next day by an independent Fibroscan operator and correlated to the EGD result. Demographic, clinical, and biochemical data were recorded and analyzed using advanced data-mining computational technology.Mean LSM was 9.94 ± 6 kPa for group A and 33.32 ± 14 kPa for group B, whereas it was 21.22 ± 3, 25.72 ± 6, 33.82 ± 8, and 46.1 ± 15 kPa for subgroups B1, B2, B3, and B4, respectively. Mean spleen diameter was 11.09 ± 1.7 cm for group A and 16.58 ± 1.6 cm for group B. However, LSM ≥17 kPa was the only independent factor for EV prediction; splenic longitudinal span ≥15 cm was a complementary predictor when LSM was <17 kPa. The overall accuracy was 98.33 ± 3.33, Mikro = 98.26%.LSM ≥17 kPa and spleen diameter ≥15 cm is a simple noninvasive algorithm that could be used for prediction of EV and discrimination among its different grades.

show abstract

“…Also, schistosomiasis was excluded based on history, antischistosomal antibody negativity, and the absence of significant periportal fibrosis in ultrasound examination. [ 36 ]…”

Section: Discussionmentioning

confidence: 99%

Liver stiffness measurement and spleen diameter as predictors for the presence of esophageal varices in chronic hepatitis C patients

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Although not statistically significant among the three groups, harmony existed between the histopathological (METAVIR) and the FibroScan results of the HCV patients (with no schistosomiasis infection). Despite the harmonization being higher among those with no PPT (70.7%) and the discrepancy being higher among those with positive schistosomal serology (66.5%), this relation was not statistically significant [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological changes

Gohary

Elyamany

Abdalla

et al. 2020

ceh

View full text Add to dashboard Cite

“…Another study from Egypt showed that higher anti‐ Schistosoma antibody titers may cause disagreements between liver biopsies and FibroScan results in patients with HCV–schistosomiasis coinfections 42 . The study described that the agreement was higher among those with HCV infection without periportal tract thickening and the disagreement was higher for those who had a positive anti‐ Schistosoma serology; however, the results were not statistically significant.…”

Section: Use Of Elastography Techniques For the Diagnosis Of Ppfmentioning

confidence: 96%

Noninvasive Assessment of Schistosoma‐Related Periportal Fibrosis

Hashim

Berzigotti

2021

J of Ultrasound Medicine

View full text Add to dashboard Cite

Schistosomiasis affects nearly 250 million individuals in the world. Hepatosplenic schistosomiasis (HSS) results in periportal fibrosis (PPF) and portal hypertension (pHTN). Ultrasound has been extensively used for the diagnosis of Schistosoma‐related PPF and a number of staging methods have been validated for this purpose such as Strickland classification and Niamey protocol. Nevertheless, the application of noninvasive techniques, particularly elastography modalities, has not been well explored. In this review, we describe the various noninvasive diagnostic tools for assessment of Schistosoma‐related PPF including US parameters, serum biomarkers, and US‐based elastography techniques. While elastography techniques have demonstrated value in the evaluation of HSS, the evidence remains limited with most studies recruiting a small number of patients. Longitudinal studies with larger sample size are required in order to devise robust criteria to accurately assess the performance of noninvasive techniques in the prediction of both regression and progression of the degree of PPF and identify their cost‐effectiveness in community screening.

show abstract

Impact of old Schistosomiasis infection on the use of transient elastography (Fibroscan) for staging of fibrosis in chronic HCV patients

Cited by 6 publications

References 26 publications

Liver stiffness measurement and spleen diameter as predictors for the presence of esophageal varices in chronic hepatitis C patients

Liver stiffness measurement and spleen diameter as predictors for the presence of esophageal varices in chronic hepatitis C patients

Comparison of hepatic and splenic stiffness in chronic hepatitis C infection with and without schistosomal infection; correlation with hepatic histopathological changes

Noninvasive Assessment of Schistosoma‐Related Periportal Fibrosis

Contact Info

Product

Resources

About