Impact of Obesity on the Risk for Polycystic Ovary Syndrome

Yildiz, Bülent O.; Knochenhauer, Eric S.; Azziz, Ricardo

doi:10.1210/jc.2007-1834

Cited by 333 publications

(226 citation statements)

References 33 publications

Supporting

Mentioning

191

Contrasting

Unclassified

Order By: Relevance

“…This state corrects on its own after few years resulting into regular ovulatory cycles as the H-P-O axis matures. 1,2 In some young girls however anovulation persists and continues as chronic anovulation. The resulting hyperestrogenism, leads to hyperandrogenism, manifesting clinically as irregular menses, amenorrhea, menorrhagia, hirsutism, acne, oily skin, alopecia, obesity or a propensity for weight gain and multiple unruptured follicles in ovaries, collectively known as polycystic ovarian syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperandrogenemia is a risk factor for MBS independent of obesity and insulin resistance, (IR), glucose intolerance, dyslipidemia, hypertension and central obesity. 1,2 Many ways of diagnosing PCOS have been described using various criteria. The NIH criteria defines PCOS as unexplained hyper androgenic anovulation, oligomenorrhea and hyperandrogenism ,either clinical or biochemical after excluding other causes of anovulation like hypothyroidism and hyperprolactinamia.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?

Choudhary¹,

Jain²,

Chaudhari³

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Polycystic ovarian syndrome [PCOS] is a complex ill understood hormonal disorder resulting in myriads of symptoms like irregular menses, hyperandrogenism, metabolic disturbances and infertility. It occurs in about 8-11% of reproductive age group women. Recently changing lifestyles and rising obesity worldwide have contributed to rise in the incidence of PCOS. Objective of the present is to study the prevalence and symptomatology of PCOS in Indian women.Methods: 170 women in reproductive age group, with irregular menstrual cycles attending OPD, voluntarily participated in a cross sectional study. All were subjected to detailed history, examination and investigated with a battery of lab tests to confirm PCOS. Out of 170 women investigated 70 women with features of PCOS were included in the study (diagnosed as PCOS by NIH criteria).Results: The overall prevalence of PCOS in the study population was, 41%. It was 16% in married women and 24 % in unmarried girls. Common menstrual irregularity was-oligomenorrhea (40%), Menorrhagia (12.8%) amenorrhea (11%). Common symptoms were hirsutism, acne, infertility and alopecia.Conclusions: PCOS is rising in young women and to some extent the changing lifestyle in urban women may be linked to it. There in a world-wide increase in the incidence of obesity, diabetes mellitus and metabolic syndrome, PCOS and its accompanying insulin resistance is contributing to it. Treating PCOS and its complications is adding to health care burden.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?

Choudhary¹,

Jain²,

Chaudhari³

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…(5,6). The different prevalence of obesity in the clinical series of women with PCOS almost certainly reflects the overall rates of obesity (30-70%) in different populations (24,25,26). Interestingly, it has been shown that obesity may also cluster in PCOS families (27).…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

European survey of diagnosis and management of the polycystic ovary syndrome: results of the ESE PCOS Special Interest Group's Questionnaire

Conway¹,

Dewailly²,

Diamanti-Kandarakis³

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: There is evidence for differences between endocrinologists and other specialists in their approach to diagnosis and management of the polycystic ovary syndrome (PCOS). Objective: A mailed survey consisting of a simple questionnaire aiming to understand current practice for diagnosis and management of the PCOS by specialists across Europe. Methods: The questionnaire consisted of 23 questions grouped to achieve information on i) the general characteristics of the respondents, ii) patients with PCOS seen by endocrinologists, iii) the main diagnostic criteria, iv) biochemical parameters used in the differential diagnosis of hyperandrogenism, v) long-term concerns, and, finally vi) treatment choices. A total of 357 questionnaires representing 13.3% of the members of European Society of Endocrinology (ESE) were available for final analysis; 93% of the respondents were endocrinologists Results: In relation to the diagnostic criteria, respondents were most likely to select menstrual irregularity as the most frequent criteria used for the diagnosis of PCOS although very high rates were achieved for the use of hirsutism and biochemical hyperandrogenism. It therefore appears that the NIH criteria were followed by the majority of respondents. The most frequent biochemical parameters in the differential diagnosis of hyperandrogenism were total testosterone or free androgen index. Obesity and type 2 diabetes were regarded as the principal long-term concerns for PCOS. The most common treatments for patients with PCOS were metformin (33%), lifestyle modification (25%), and oral contraceptives (22%). More direct treatments of infertility include clomiphene citrate alone or in combination with metformin, prescribed by 9 and 23%, respectively, whereas only 6% used other methods for induction of ovulation.

show abstract

“…diagnosis, the prevalence of overweight and obesity in the PCOS population is above 50% in the United States [109] and between 30% and 50% in Europe [110]. Obesity by itself is associated with insulin resistance and compensatory hyperinsulinemia, which is worst following intra-abdominal accumulation of fat.…”

Section: Obesity and Pcos-atmentioning

confidence: 99%

Insulin and hyperandrogenism in women with polycystic ovary syndrome

Baptiste

Battista

Trottier

et al. 2010

The Journal of Steroid Biochemistry and Molecular Biology

259

199

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a very common endocrine disorder characterized by chronic anovulation, clinical and/or biochemical hyperandrogenism, and/or polycystic ovaries. But most experts consider that hyperandrogenism is the main characteristic of PCOS. Several theories propose different mechanisms to explain PCOS manifestations: (1) a primary enzymatic default in the ovarian and/or adrenal steroidogenesis; (2) an impairment in gonadotropin releasing hormone (GnRH) secretion that promotes luteal hormone (LH) secretion; or (3) alterations in insulin actions that lead to insulin resistance with compensatory hyperinsulinemia. However, in the past 20 years there has been growing evidence supporting that defects in insulin actions or in the insulin signalling pathways are central in the pathogenesis of the syndrome. Indeed, most women with PCOS are metabolically insulin resistant, in part due to genetic predisposition and in part secondary to obesity. But some women with typical PCOS do not display insulin resistance, which supports the hypothesis of a genetic predisposition specific to PCOS that would be revealed by the development of insulin resistance and compensatory hyperinsulinemia in most, but not all, women with PCOS. However, these hypotheses are not yet appropriately confirmed, and more research is still needed to unravel the true pathogenesis underlying this syndrome. The present review thus aims at discussing new concepts and findings regarding insulin actions in PCOS women and how it is related to hyperandrogenemia.

show abstract

Impact of Obesity on the Risk for Polycystic Ovary Syndrome

Abstract: Our results suggest that the risk of PCOS is only minimally increased with obesity, although the degree of obesity of PCOS patients has increased, similar to that observed in the general population. These data indicate that obesity in PCOS reflects environmental factors to a great extent.

Cited by 333 publications

References 33 publications

Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?

Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?

European survey of diagnosis and management of the polycystic ovary syndrome: results of the ESE PCOS Special Interest Group's Questionnaire

Insulin and hyperandrogenism in women with polycystic ovary syndrome

Contact Info

Product

Resources

About