Impact of Obesity on the Left Ventricular Functions and Morphology of Healthy Asian Indians

Chadha, DS; Gupta, Nidhi; Goel, Mahesh C.; Pandey, Ravindra Mohan; Kondal, Dimple; Ganjoo, RK; Misra, Anoop

doi:10.1089/met.2008.0054

Cited by 21 publications

(15 citation statements)

References 22 publications

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“…Of importance is that LV remodeling (i.e., increased LVEDd and LVESd) was remarkably increased in obese animals compared to that in their normal counterparts. Accordingly, the results of the present study support the findings from previous clinical observational studies [31-33]. Another principal finding in the current study using Masson's Trichrome staining showed that the fibrotic area was substantially increased in obese mice.…”

Section: Discussionsupporting

confidence: 92%

“…Although the role of obesity in impairing LV function and increasing LV remodeling have been keenly investigated in previously clinical observational studies, the study of heart function in animal models of obesity has seldom been reported [31-33]. The most important finding in this experimental study is that LVEF and FS were significantly lower in obese mice than those in normal controls.…”

Section: Discussionmentioning

confidence: 78%

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Obesity suppresses circulating level and function of endothelial progenitor cells and heart function

et al. 2012

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Background and aimThis study tested the hypothesis that obesity suppresses circulating number as well as the function of endothelial progenitor cells (EPCs) and left ventricular ejection fraction (LVEF).MethodsHigh fat diet (45 Kcal% fat) was given to 8-week-old C57BL/6 J mice (n = 8) for 20 weeks to induce obesity (group 1). Another age-matched group (n = 8) were fed with control diet for 20 weeks as controls (group 2). The animals were sacrificed at the end of 20 weeks after obesity induction.ResultsBy the end of study period, the heart weight, body weight, abdominal fat weight, serum levels of total cholesterol and fasting blood sugar were remarkably higher in group 1 than in group 2 (all p<0.01). The circulating level of EPCs (C-kit/CD31, Sca-1/KDR, CXCR4/CD34) was significantly lower in group 1 than in group 2 (p<0.03) at 18 h after critical limb ischemia induction. The angiogenesis and migratory ability of bone marrow-derived EPCs was remarkably impaired in group 1 compared to that in group 2 (all p<0.01). The repair ability of aortic endothelium damage by lipopolysaccharide was notably attenuated in group 1 compared with that in group 2 (p<0.01). Collagen deposition (Sirius red staining) and fibrotic area (Masson's Trichrome staining) in LV myocardium were notably increased in group 1 compared with group 2 (p<0.001). LVEF was notably lower, whereas LV end-diastolic and end-systolic dimensions were remarkably higher in group 1 than in group 2 (all p<0.001).ConclusionsObesity diminished circulating EPC level, impaired the recovery of damaged endothelium, suppressed EPC angiogenesis ability and LVEF, and increased LV remodeling.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 78%

Obesity suppresses circulating level and function of endothelial progenitor cells and heart function

et al. 2012

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“…A study of Asian Indians demonstrated significant morphological and functional cardiac abnormalities in people with uncomplicated obesity, but its size of 239 study subjects was too small for the data to be generalized. 20 The Multi-Ethnic Study of Atherosclerosis (MESA) also showed a significant relationship of obesity with concentric LV remodeling in a multi-ethnic group including Chinese-Americans but could not clarify an ethnic-specific relationship. 21 .07) severe obese groups).…”

Section: Bmi LV Dysfunction and Remodelingmentioning

confidence: 99%

Effect of Overweight and Obesity (Defined by Asian-Specific Cutoff Criteria) on Left Ventricular Diastolic Function and Structure in a General Korean Population

Ryoo

Choi

et al. 2016

Circ J

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Background: Although obesity is a well-known risk factor for cardiovascular disease, the cutoff of body mass index (BMI) for elevated cardiovascular risk is still controversial in Asian. Thus, this study was conducted to investigate the functional and structural changes of the left ventricle (LV) according to the degree of obesity in a general Korean population. Methods and Results:A total of 31,334 apparently healthy Korean adults who underwent echocardiography were enrolled. The study population was stratified into 5 groups according to the degree of obesity classified by the AsianPacific obesity guideline. The odd ratios (ORs) with 95% confidence interval (CI) of impaired LV diastolic function, LV remodeling, and hypertrophy were compared among the 5 groups using multivariable logistic regression analysis. When the normal group was set as the reference, the adjusted ORs (95% CI) for impaired LV diastolic function showed a proportional relationship with BMI [OR; 0.86 (95% CI 0.59-1.22) in underweight, 1.81 (95% CI 1.63-2.00) in overweight, 2.75 (95% CI 2.49-3.03) in obese, and 4.34 (95% CI 3.65-5.16) in severe obese]. Adjusted ORs for LV remodeling and hypertrophy significantly increased proportional to BMI. Conclusions:Even with strict classification of obesity by the Asian-Pacific guideline, BMI of more than overweight (≥23 kg/m 2 ) was significantly associated with impaired LV diastolic function, remodeling, and hypertrophy. (Circ J 2016; 80: 2489 -2495

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“…R apidly changing dietary practices and an increasingly sedentary lifestyle predispose to obesity-related noncommunicable diseases, including insulin resistance, the metabolic syndrome, type 2 diabetes mellitus (T2DM), coronary artery diseases (CAD), polycystic ovarian syndrome (PCOS), nonalcoholic fatty liver disease (NAFLD), and site-specific neoplasms, both in children and in adults (1)(2)(3)(4). Recent data show that obesity-related noncommunicable diseases are increasing in many developing countries (2).…”

Section: Introductionmentioning

confidence: 99%

Childhood Obesity in Developing Countries: Epidemiology, Determinants, and Prevention

et al. 2012

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Rapidly changing dietary practices and a sedentary lifestyle have led to increasing prevalence of childhood obesity (5-19 yr) in developing countries recently: 41.8% in Mexico, 22.1% in Brazil, 22.0% in India, and 19.3% in Argentina. Moreover, secular trends indicate increasing prevalence rates in these countries: 4.1 to 13.9% in Brazil during 1974-1997, 12.2 to 15.6% in Thailand during 1991-1993, and 9.8 to 11.7% in India during 2006-2009. Important determinants of childhood obesity include high socioeconomic status, residence in metropolitan cities, female gender, unawareness and false beliefs about nutrition, marketing by transnational food companies, increasing academic stress, and poor facilities for physical activity. Childhood obesity has been associated with type 2 diabetes mellitus, the early-onset metabolic syndrome, subclinical inflammation, dyslipidemia, coronary artery diseases, and adulthood obesity. Therapeutic lifestyle changes and maintenance of regular physical activity through parental initiative and social support interventions are the most important strategies in managing childhood obesity. Also, high-risk screening and effective health educational programs are urgently needed in developing countries.

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Impact of Obesity on the Left Ventricular Functions and Morphology of Healthy Asian Indians

Abstract: Asian Indians with uncomplicated obesity (without associated co-morbidities) had significant morphological and functional cardiac dysfunction (systolic and diastolic), which correlated with anthropometric variables.

Cited by 21 publications

References 22 publications

Obesity suppresses circulating level and function of endothelial progenitor cells and heart function

Obesity suppresses circulating level and function of endothelial progenitor cells and heart function

Effect of Overweight and Obesity (Defined by Asian-Specific Cutoff Criteria) on Left Ventricular Diastolic Function and Structure in a General Korean Population

Childhood Obesity in Developing Countries: Epidemiology, Determinants, and Prevention

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