Impact of Obesity on Outcomes of Operable Breast Cancer: A Retrospective Cohort Study

Engkakul, Tanapat; Thnogtang, Nuntakorn; Nimmannit, Akarin; Chuthapisith, Suebwong; Akewanlop, Charuwan

doi:10.31557/apjcp.2020.21.4.953

Cited by 5 publications

(6 citation statements)

References 29 publications

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“…There were 38 studies 43,45,46,59‐91,211,212 (40 cohorts; 2,361,275 participants) of cancer populations (Table S3); 17 cohorts were in East Asia, 10 cohorts in North America, 7 in Europe, 2 were international cohorts, 2 were in West Asia, and 1 each in South America and Africa. Mean age of participants ranged from 17 to 75 years.…”

Section: Resultsmentioning

confidence: 99%

Associations between body mass index and all‐cause mortality: A systematic review and meta‐analysis

2023

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SummaryFasting insulin and c‐reactive protein confound the association between mortality and body mass index. An increase in fat mass may mediate the associations between hyperinsulinemia, hyperinflammation, and mortality. The objective of this study was to describe the “average” associations between body mass index and the risk of mortality and to explore how adjusting for fasting insulin and markers of inflammation might modify the association of BMI with mortality. MEDLINE and EMBASE were searched for studies published in 2020. Studies with adult participants where BMI and vital status was assessed were included. BMI was required to be categorized into groups or parametrized as non‐first order polynomials or splines. All‐cause mortality was regressed against mean BMI squared within seven broad clinical populations. Study was modeled as a random intercept. β coefficients and 95% confidence intervals are reported along with estimates of mortality risk by BMIs of 20, 30, and 40 kg/m2. Bubble plots with regression lines are drawn, showing the associations between mortality and BMI. Splines results were summarized. There were 154 included studies with 6,685,979 participants. Only five (3.2%) studies adjusted for a marker of inflammation, and no studies adjusted for fasting insulin. There were significant associations between higher BMIs and lower mortality risk in cardiovascular (unadjusted β −0.829 [95% CI −1.313, −0.345] and adjusted β −0.746 [95% CI −1.471, −0.021]), Covid‐19 (unadjusted β −0.333 [95% CI −0.650, −0.015]), critically ill (adjusted β −0.550 [95% CI −1.091, −0.010]), and surgical (unadjusted β −0.415 [95% CI −0.824, −0.006]) populations. The associations for general, cancer, and non‐communicable disease populations were not significant. Heterogeneity was very large (I2 ≥ 97%). The role of obesity as a driver of excess mortality should be critically re‐examined, in parallel with increased efforts to determine the harms of hyperinsulinemia and chronic inflammation.

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Section: Resultsmentioning

confidence: 99%

Associations between body mass index and all‐cause mortality: A systematic review and meta‐analysis

2023

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“…Se estima que cerca de 20 000 muertes/año podrían evitarse, solo en Estados Unidos, en pacientes mayores de 50 años con cáncer de mama si durante su vida reproductiva mantuvieran valores de IMC menores a 25 Kg/m 2 (30). La evidencia demuestra que las pacientes menopaúsicas con diagnóstico de cáncer de mama tienen valores de IMC significativamente superiores a pacientes controles en el mismo rango de edad (31). Estudios prospectivos sobre cáncer y nutrición demostraron que el mayor riesgo de desarrollar cáncer de mama está relacionado a la ingesta de ácidos grasos saturados y alcohol, mientras que entre las menopáusicas tienen mayor riesgo aquellas con mayor IMC y menor actividad física (32).…”

Section: Factores De Riesgo De Obesidad Y Cáncer De Mamaunclassified

Sobrepeso, obesidad y cáncer de mama

Mejia-Montilla¹,

Reyna-Villasmil²

2022

RSOGV

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La obesidad produce trastornos metabólicos e insuficiencia orgánica y aumenta el riesgo de muchos tipos de cáncer. La posible relación entre obesidad y cáncer de mama depende de complicadas interacciones metabólicas entre estrógenos, insulina y actividad endocrina de los adipocitos. Las pacientes obesas tienen tres veces más riesgo de desarrollar cáncer comparado con las mujeres con peso normal. Además, las mujeres obesas tienden a presentar tumores no palpables, lo que lleva a diagnósticos en estadios más avanzados de la enfermedad y peores resultados por tratamientos tardíos. También tienen mayor riesgo de complicaciones anestésicas, quirúrgicas y posquirúrgicas. La obesidad es un factor de riesgo modificable para el cáncer de mama. Limitar la frecuencia de sobrepeso y obesidad en las mujeres puede disminuir de la tasa de morbimortalidad por esta condición. El objetivo de esta revisión fue evaluar la relación entre sobrepeso, obesidad y cáncer de mama. Palabras clave: Obesidad, Cáncer de mama, Diagnóstico, Tratamiento.

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“…But the tolerance of chemotherapy in obese patients was greater than non obese patients and they have less severe neutropenia. 47 In breast cancer patients, prognosis becomes poor due to obesity or high BMI which is also related to menopausal status. Diagnosis for disease free survival/overall survival is not being affected by obesity.…”

Section: Breast Cancer and Obesity Associated Risksmentioning

confidence: 99%

Review on: relevance of breast cancer recurrence with body mass index or obesity

Jangir

Kchhawa

2022

Int Surg J

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Breast cancer is considered to be the second most life taking malignancy after lung cancer in the world. Some studies also show that changed lifestyle including alcohol and junk food is also increasing incidence or prevalence. Obesity is one of the side effects of the changed lifestyle so it can be a key to evaluate the relationship between obesity and breast cancer. Recurrence happens in about 40% of the breast cancer cases and is lethal too. Besides the treatments developed, breast cancer mortality still is increasing. Relationship of obesity and breast cancer is in such a way that obesity is not responsible for the causing of cancer but obesity can increase the risk of recurrence or improper treatment due to higher level of hormones which may directly or indirectly affect the pathways.

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Impact of Obesity on Outcomes of Operable Breast Cancer: A Retrospective Cohort Study

Abstract: The explanation of these emerging events has been described in few researches as obesity increases numbers of pre-adipocytes and inflammatory cells, higher levels of leptin and free fatty acids, and greater release of cytokines and other inflammatory compounds (Goodwin, 2015;

Cited by 5 publications

References 29 publications

Associations between body mass index and all‐cause mortality: A systematic review and meta‐analysis

Associations between body mass index and all‐cause mortality: A systematic review and meta‐analysis

Sobrepeso, obesidad y cáncer de mama

Review on: relevance of breast cancer recurrence with body mass index or obesity

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