Impact of obesity on outcomes of paediatric acute pancreatitis based on a national administrative database

Murata, Atsuhiko; Ohtani, Makoto; Muramatsu, Keiji; Kobori, Shinichiro; Tomioka, Shinichi; Matsuda, Shinya

doi:10.1111/ijpo.12041

Cited by 11 publications

(14 citation statements)

References 31 publications

(52 reference statements)

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“…1 The rising incidence and severity of AP probably reflects rising incidence of obesity in children and increasing awareness among pediatricians. [2][3][4] In spite of the growing awareness, pancreatitis is associated with considerable morbidity in children. Complications in the delayed phase (>4 weeks) of AP include infection and development of pancreatic fluid collections (PFC).…”

Section: Introductionmentioning

confidence: 99%

Endoscopic drainage of pancreatic fluid collections: Long‐term outcomes in children

Nabi

Lakhtakia

Basha

et al. 2017

Digestive Endoscopy

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Section: Introductionmentioning

confidence: 99%

Endoscopic drainage of pancreatic fluid collections: Long‐term outcomes in children

Nabi

Lakhtakia

Basha

et al. 2017

Digestive Endoscopy

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“…Taken together, study results indicate that the presence of obesity has negative effects on the trajectory of AP [16, 19–24]. Patients with obesity are at a greater risk for fatty infiltration of the pancreas.…”

Section: Effects Of Metabolic Syndromementioning

confidence: 86%

“…Age and obesity have been identified by many studies as easily accessible and negative predictive factors in patients with AP [27–30]. An increased risk of early shock, pulmonary and kidney failure, and an extended hospital stay are associated with obesity [16, 19–24, 31]. De Waele et al [32] found that in patients with AP, obesity is correlated with disease severity and an increased risk of local complications and mortality.…”

Section: Effects Of Metabolic Syndromementioning

confidence: 99%

Relationships between Metabolic Comorbidities and Occurrence, Severity, and Outcomes in Patients with Acute Pancreatitis: A Narrative Review

Guo

et al. 2019

BioMed Research International

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Background. The population of patients with acute pancreatitis treated by the staff at our department of gastroenterology includes those with mild and self-limited disease ranging to those with severe and fatal disease. Early diagnosis and accurate prediction of the severity and outcome of this disease, which is commonly seen by our department, is important for a successful outcome. Metabolic comorbidities (e.g., diabetes mellitus, fatty liver, obesity, and metabolic syndrome) are relevant to the severity and progression of many diseases. The objective of this review was to examine clinical relationships between metabolic comorbidities and occurrence, severity, and outcome of acute pancreatitis.

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“…20 Similar to adults, obese children with AP have worse outcomes compared to non-obese: severe AP, length of stay, medical costs, mortality are significantly higher in obese individuals. 27 The role of obesity as a risk factor for ARP or CP is largely unknown. In a study by Ammann et al, progression to CP in a group of adult patients was slower over time if BMI was >25 and they underwent a drainage surgery previously.…”

Section: Discussionmentioning

confidence: 99%

963 Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

Uç¹,

Abu‐El‐Haija²,

Barth³

et al. 2016

Gastroenterology

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Objective-To assess the impact of obesity on pediatric acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). Methods-We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used Cochran-Armitage to assess trends, Jonckheere-Terpstra to determine associations. Results-Of 446 subjects (ARP = 241, CP = 205), 22 were underweight, 258 normal weight, 75 overweight, 91 obese. The BMI groups were similar in sex, race, age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared to children with normal weight, obese or overweight were older at first acute pancreatitis (AP) episode and diagnosed with CP at an older age. Obese or overweight were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, require total pancreatectomy with islet autotransplantation (TPIAT). Diabetes was similar among all groups. Conclusions-Obesity or overweight seems to delay the initial AP episode and diagnosis of CP compared to normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.

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Impact of obesity on outcomes of paediatric acute pancreatitis based on a national administrative database

Abstract: This study demonstrated that obesity significantly influenced the outcomes of paediatric acute pancreatitis.

Cited by 11 publications

References 31 publications

Endoscopic drainage of pancreatic fluid collections: Long‐term outcomes in children

Endoscopic drainage of pancreatic fluid collections: Long‐term outcomes in children

Relationships between Metabolic Comorbidities and Occurrence, Severity, and Outcomes in Patients with Acute Pancreatitis: A Narrative Review

963 Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

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