Impact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus

Wu, Mei‐Zhen; Chen, Yan; Yuan, Zuyi; Zhen, Zhe; Yu, Yu-Juan; Liu, Yingxian; Yuen, Mantak; Ho, Lai‐Ming; Lam, Karen S.L.; Tse, Hung‐Fat; Yiu, Kai‐Hang

doi:10.1093/ehjci/jey217

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…Reported associations of LVDD in patients with T2DM are age, female gender, duration of T2DM, HbA 1c status, obesity, higher systolic blood pressure, and presence of albuminuria, CKD ≥ Stage 3, and retinopathy (1,15,17,19,21,(23)(24)(25)(26). Upon univariate analysis, we found that age, hypertension, hyperlipidemia, insulin therapy, and ethnicity were correlated with presence of asymptomatic LVDD.…”

Section: Discussionmentioning

confidence: 73%

Prevalence and Predictors of Left Ventricular Diastolic Dysfunction in Malaysian Patients With Type 2 Diabetes Mellitus Without Prior Known Cardiovascular Disease

Chee

Tan

Luqman

et al. 2021

Front. Cardiovasc. Med.

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Objective: Existing data showed that left ventricular diastolic dysfunction is common in individuals with type 2 diabetes mellitus (T2DM). However, most of the studies included diabetic patients who have prior cardiovascular disease, which might be the compounding factor for ventricular dysfunction. This study aimed to determine the prevalence and predictors of left ventricular diastolic dysfunction in an Asian population with T2DM without prior cardiovascular disease using the latest recommended echocardiographic assessment for left ventricular diastolic dysfunction.Design and Participants: This is a cross-sectional study in which eligible patients with T2DM without history of coronary artery disease, heart failure, or valvular heart disease were recruited. Demographic data, diabetic control, comorbidities, microvascular/macrovascular complications, and medications prescribed were recorded. Venous blood was sent to test for B-type natriuretic peptide, and transthoracic echocardiography was performed to assess left ventricular dysfunction.Setting: This study was performed in a tertiary healthcare center located in Kuala Lumpur, Malaysia.Results: Of the 301 patients, 83.1% have had T2DM for >10 years, with 45.8% being poorly controlled. Comorbidities include hypertension (77.1%), hyperlipidemia (91.0%), and pre-obesity/obesity (72.9%). Majority had absence of microvascular (albuminuria, retinopathy, and neuropathy) and macrovascular (peripheral vascular disease and stroke) complications. None had raised B-type natriuretic peptide levels, and 93.7% had no symptoms of heart failure. On echocardiographic assessment, 70.1% had left ventricular diastolic dysfunction, and 90.5% had Grade 1/mild severity. Age, ethnicity, insulin therapy, presence of hypertension, and hyperlipidemia were significantly associated with left ventricular diastolic dysfunction. Older T2DM patients of Chinese ethnicity and on insulin are about two times more likely to develop left ventricular diastolic dysfunction.Conclusion: There was a high prevalence of asymptomatic left ventricular diastolic dysfunction among patients with T2DM without prior known cardiovascular disease. Older age, insulin therapy, and Chinese ethnicity were risk factors for left ventricular diastolic dysfunction in T2DM.

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Section: Discussionmentioning

confidence: 73%

Prevalence and Predictors of Left Ventricular Diastolic Dysfunction in Malaysian Patients With Type 2 Diabetes Mellitus Without Prior Known Cardiovascular Disease

Chee

Tan

Luqman

et al. 2021

Front. Cardiovasc. Med.

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“…Although we [45] and others [51,52] have previously demonstrated the close relationship between obesity as measured by BMI and LV remodelling, and that an increase in BMI was negatively associated with diastolic function [4,51,53], there are also limitations in using BMI to distinguish between fat mass and fat-free mass. In this regard, circulating AFABP level has been shown to correlate with fat mass as measured by bioelectrical impedance and magnetic resonance imaging independent of BMI levels [54].…”

Section: Table 3 Multiple Linear Regression Showing the Association Omentioning

confidence: 82%

“…Chronic kidney disease was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m 2 AFABP, adipocyte fatty acid-binding protein; BMI, body mass index; CKD, chronic kidney disease; E, trans-mitral early diastolic peak velocity; e′, early diastolic peak velocity of mitral valve at septal or lateral annulus; LV, left ventricular patients. In prospective echocardiography studies, retinopathy [43], BNP [44], obesity [45] and female sex [46] were found to be associated with longitudinal changes of LV remodelling and myocardial dysfunction in T2DM patients. In this study, we demonstrated that baseline circulating AFABP level was also independently associated with increase in LV mass and worsening of average E/e′ ratio over a 28-month follow-up period, which provided firm evidence that an elevated circulating AFABP level not only correlated with cross-sectional assessments of LV mass and average E/e′ ratio, but could also predict a further deterioration of LV remodelling and diastolic function in T2DM patients.…”

Section: Table 3 Multiple Linear Regression Showing the Association Omentioning

confidence: 93%

Association between adipocyte fatty acid-binding protein with left ventricular remodelling and diastolic function in type 2 diabetes: a prospective echocardiography study

Lee

Chen

et al. 2020

Cardiovasc Diabetol

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Background The relationship between adipocyte fatty acid-binding protein (AFABP) and cardiac remodelling has been reported in cross-sectional studies, although with conflicting results. Type 2 diabetes mellitus (T2DM) is associated with left ventricular (LV) hypertrophy and diastolic dysfunction, as well as elevated circulating AFABP levels. Here we investigated prospectively the association between AFABP with the longitudinal changes of cardiac remodelling and diastolic dysfunction in T2DM. Methods Circulating AFABP levels were measured in 176 T2DM patients without cardiovascular diseases (CVD) at baseline. All participants received detailed transthoracic echocardiography both at baseline and after 1 year. Multivariable linear and Cox regression analyses were used to evaluate the associations of circulating AFABP levels with changes in echocardiography parameters and incident major adverse cardiovascular events (MACE), respectively. Results The median duration between baseline and follow-up echocardiography assessments was 28 months. Higher sex-specific AFABP quartiles at baseline were associated with increase in LV mass and worsening of average E/e′ (all P < 0.01). Multivariable linear regression demonstrated that AFABP in the highest quartile was independently associated with both increase in LV mass (β = 0.89, P < 0.01) and worsening of average E/e′ (β = 0.57, P < 0.05). Moreover, multivariable Cox regression analysis showed that elevated baseline circulating AFABP level independently predicted incident MACE (HR 2.65, 95% CI 1.16–6.05, P < 0.05) after adjustments for age, sex, body mass index, glycated haemoglobin, hypertension, dyslipidemia and presence of chronic kidney disease. Conclusion Circulating AFABP level at baseline predicted the development of LV hypertrophy, diastolic dysfunction and MACE in T2DM patients without CVD.

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“…Prior cross-sectional studies using echocardiography have highlighted various factors contributing to left ventricular hypertrophy and diastolic dysfunction in individuals with type 2 diabetes, including oxidative stress [ 36 ], autonomic dysfunction [ 37 ], microvascular disease [ 38 ], obesity [ 39 ] and poor glycaemic control [ 40 ]. Prospective echocardiography studies have also shown that longitudinal changes in left ventricular remodelling and myocardial dysfunction in individuals with type 2 diabetes are associated with factors such as retinopathy [ 41 ], B-type natriuretic peptide (BNP) [ 42 ], obesity [ 43 ] and female sex [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated ITGA1 levels in type 2 diabetes: implications for cardiac function impairment

Su,

Hou,

Cai

et al. 2024

Diabetologia

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Aims/hypothesis Type 2 diabetes mellitus is known to contribute to the development of heart failure with preserved ejection fraction (HFpEF). However, identifying HFpEF in individuals with type 2 diabetes early on is often challenging due to a limited array of biomarkers. This study aims to investigate specific biomarkers associated with the progression of HFpEF in individuals with type 2 diabetes, for the purpose of enabling early detection and more effective management strategies. Methods Blood samples were collected from individuals with type 2 diabetes, both with and without HFpEF, for proteomic analysis. Plasma integrin α1 (ITGA1) levels were measured and compared between the two groups. Participants were further categorised based on ITGA1 levels and underwent detailed transthoracic echocardiography at baseline and during a median follow-up period of 30 months. Multivariable linear and Cox regression analyses were conducted separately to assess the associations between plasma ITGA1 levels and changes in echocardiography indicators and re-hospitalisation risk. Additionally, proteomic data for the individuals’ left ventricles, from ProteomeXchange database, were analysed to uncover mechanisms underlying the change in ITGA1 levels in HFpEF. Results Individuals with type 2 diabetes and HFpEF showed significantly higher plasma ITGA1 levels than the individuals with type 2 diabetes without HFpEF. These elevated ITGA1 levels were associated with left ventricular remodelling and impaired diastolic function. Furthermore, during a median follow-up of 30 months, multivariable analysis revealed that elevated ITGA1 levels independently correlated with deterioration of both diastolic and systolic cardiac functions. Additionally, higher baseline plasma ITGA1 levels independently predicted re-hospitalisation risk (HR 2.331 [95% CI 1.387, 3.917], p=0.001). Proteomic analysis of left ventricular myocardial tissue provided insights into the impact of increased ITGA1 levels on cardiac fibrosis-related pathways and the contribution made by these changes to the development and progression of HFpEF. Conclusions/interpretation ITGA1 serves as a biomarker for monitoring cardiac structural and functional damage, can be used to accurately diagnose the presence of HFpEF, and can be used to predict potential deterioration in cardiac structure and function as well as re-hospitalisation for individuals with type 2 diabetes. Its measurement holds promise for facilitating risk stratification and early intervention to mitigate the adverse cardiovascular effects associated with diabetes. Data availability The proteomic data of left ventricular myocardial tissue from individuals with type 2 diabetes, encompassing both those with and without HFpEF, is available from the ProteomeXchange database at http://proteomecentral.proteomexchange.org. Graphical Abstract

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Impact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus

Cited by 6 publications

References 45 publications

Prevalence and Predictors of Left Ventricular Diastolic Dysfunction in Malaysian Patients With Type 2 Diabetes Mellitus Without Prior Known Cardiovascular Disease

Prevalence and Predictors of Left Ventricular Diastolic Dysfunction in Malaysian Patients With Type 2 Diabetes Mellitus Without Prior Known Cardiovascular Disease

Association between adipocyte fatty acid-binding protein with left ventricular remodelling and diastolic function in type 2 diabetes: a prospective echocardiography study

Elevated ITGA1 levels in type 2 diabetes: implications for cardiac function impairment

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