Impact of Obesity on Cardiovascular Disease

Zalesin, Kerstyn C.; Franklin, Barry A.; Miller, Wendy; Peterson, Eric D.; McCullough, Peter A.

doi:10.1016/j.mcna.2011.06.005

Cited by 168 publications

(128 citation statements)

References 116 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…Obesity has been shown to be a predictor of cardiovascular disease (CVD), including CHD, stroke, and heart failure, in a large number of previous cohort studies 6, 7, 8. Ndumele et al have also recently shown that the adjustment for obesity‐related risk factors such as diabetes mellitus, hypertension, and dyslipidemia considerably attenuates the association between obesity and CHD and stroke but not heart failure 7.…”

Section: Introductionmentioning

confidence: 99%

Associations of Obesity With Incident Hospitalization Related to Peripheral Artery Disease and Critical Limb Ischemia in the ARIC Study

Hicks

Yang

Ndumele

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundWe conducted an analysis of data from the ARIC (Atherosclerosis Risk in Communities) study to assess the independent association of obesity with peripheral artery disease (PAD) and critical limb ischemia (CLI).Methods and ResultsAll black and white ARIC participants without prevalent PAD at baseline (1987–1989) were included. We used Cox proportional hazards models adjusting for potential confounders and then potential mediators to quantify the association between body mass index (BMI) and incident hospitalizations related to PAD without CLI and with CLI through 2013. Our analysis included 13 988 men and women followed for a median of 24 years. Incident PAD without CLI and PAD with CLI occurred in 373 and 201 participants, respectively. After adjusting for potential confounders, higher BMI at baseline was associated with increased risk of PAD without CLI when BMI was modeled continuously (hazard ratio per 1‐SD increment in BMI: 1.23; 95% confidence interval, 1.11–1.37) and with PAD with CLI regardless of whether BMI was modeled categorically (P<0.05) or continuously (hazard ratio per 1‐SD increment in BMI: 1.51; 95% confidence interval, 1.34–1.69). The associations of BMI with PAD without CLI and with CLI were attenuated after further accounting for potential mediators but remained significant for PAD with CLI when BMI was linearly modeled (hazard ratio per 1‐SD increment in BMI: 1.19; 95% confidence interval, 1.04–1.36). The positive association between BMI and PAD with CLI was stronger than the association between BMI and PAD without CLI for all models (P<0.001).ConclusionsIn the general population, BMI is positively associated with incident hospitalized PAD after adjusting for potential confounders, particularly its most severe form of CLI. Maintaining an optimal weight, in addition to controlling other cardiovascular risk factors, may play a role in reducing risk of PAD with CLI.

show abstract

Section: Introductionmentioning

confidence: 99%

Associations of Obesity With Incident Hospitalization Related to Peripheral Artery Disease and Critical Limb Ischemia in the ARIC Study

Hicks

Yang

Ndumele

et al. 2018

JAHA

View full text Add to dashboard Cite

show abstract

“…[2,3] The metabolic consequences of obesity, more particularly abdominal obesity associated with increased visceral adipose tissue, include atherogenic dyslipidaemia, [4] impaired glucose metabolism, [5] hypertension [6] and silent inflammation, [7] all CVD risk factors. [8,9] Obesity has a major impact on CVD, such as heart failure, coronary heart disease, sudden cardiac death, and atrial fibrillation, and is associated with reduced overall survival. [2,3] Weight loss is considered to be the initial step that helps to prevent or to control the clinical consequences of obesity.…”

mentioning

confidence: 99%

Cardiovascular Risk-Benefit Profile of Sibutramine

Scheen

2010

American Journal Cardiovascular Drugs

View full text Add to dashboard Cite

SUMMARYSibutramine is a combined norepinephrine and serotonin reuptake inhibitor used as an antiobesity agent to reduce appetite and promote weight loss in combination with diet and exercise. At a daily dose of 10-20 mg, it was initially considered to have a good safety profile as it does not induce primary pulmonary hypertension or adverse effects on cardiac valves, in contrast to what was previously reported with some other anti-obesity agents. However, it exerts

show abstract

“…OSA can be seen in non-obese patients with craniofacial abnormality and children with enlarged tonsils and adenoids too [8][9][10] . The growing prevalence of obesity and the increasing population body mass index has created major public health challenges [11] . Obstructive sleep apnea has been independently linked with hypertension, atrial fibrillation, cardiac disease, worsening of diabetes, insulin resistance, peri-operative and postoperative complications and coronary artery disease (CAD), to name the few [12][13][14][15][16] .…”

Section: Obstructive Sleep Apneamentioning

confidence: 99%

Diabetes, sleep apnea, obesity and cardiovascular disease: Why not address them together?

Surani

2014

WJD

View full text Add to dashboard Cite

Obesity, sleep apnea, diabetes and cardiovascular diseases are some of the most common diseases encountered by the worldwide population, with high social and economic burdens. Significant emphasis has been placed on obtaining blood pressure, body mass index, and placing importance on screening for signs and symptoms pointing towards cardiovascular disease. Symptoms related to sleep, or screening for sleep apnea has been overlooked by cardiac, diabetic, pulmonary and general medicine clinics despite recommendations for screening by several societies. In recent years, there is mounting data where obesity and obstructive sleep apnea sit at the epicenter and its control can lead to improvement and prevention of diabetes and cardiovascular complications. This editorial raises questions as to why obstructive sleep apnea screening should be included as yet another vital sign during patient initial inpatient or outpatient visit.

show abstract

Impact of Obesity on Cardiovascular Disease

Cited by 168 publications

References 116 publications

Associations of Obesity With Incident Hospitalization Related to Peripheral Artery Disease and Critical Limb Ischemia in the ARIC Study

Associations of Obesity With Incident Hospitalization Related to Peripheral Artery Disease and Critical Limb Ischemia in the ARIC Study

Cardiovascular Risk-Benefit Profile of Sibutramine

Diabetes, sleep apnea, obesity and cardiovascular disease: Why not address them together?

Contact Info

Product

Resources

About