Impact of Obesity on Cardiovascular Disease

Zalesin, Kerstyn C.; Franklin, Barry A.; Miller, Wendy; Peterson, Eric D.; McCullough, Peter A.

doi:10.1016/j.ecl.2008.06.004

Cited by 130 publications

(94 citation statements)

References 116 publications

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“…A number of experimental and clinical studies have consistently demonstrated impaired arterial function manifested by reduced endothelium-dependent vasodilatation in obesity (Tziomalos et al, 2010;Lobato et al, 2010;Zalesin et al, 2008). We have previously demonstrated that obesity induced by monosodium glutamate (MSG) impairs microvascular reactivity in rats.…”

Section: Introductionmentioning

confidence: 96%

Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats

et al. 2012

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Section: Introductionmentioning

confidence: 96%

Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats

et al. 2012

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“…This is marked by increases in incident and prevalent cases of both diseases over the past several decades driven by rising rates of common risk factors for both CKD and HF including obesity, metabolic syndrome, diabetes, and hypertension [3,4,5,6]. Measures of renal function can now be calculated with a reasonable degree of accuracy with the use of multivariate equations based on serum creatinine and other demographic variables including age [7].…”

Section: Introductionmentioning

confidence: 99%

Impact of Reduced Kidney Function on Cardiopulmonary Fitness in Patients with Systolic Heart Failure

et al. 2010

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Background: Decreased renal function has been consistently associated with increased mortality among patients with systolic heart failure. The relationship between estimated glomerular filtration rate (eGFR) and other high-risk features including reduced cardiorespiratory fitness has not been previously reported in this patient population. Methods: The HF-ACTION trial was a prospective, randomized trial of exercise therapy versus usual care in patients with systolic heart failure. Patients with class 2–4 heart failure and a left ventricular ejection fraction of ≤35% were recruited. Serum creatinine was measured up to 1 year prior to entry. The 4-variable modified Modification of Diet in Renal Disease equation was used to calculate eGFR. Peak oxygen consumption (peak VO₂) was directly measured using gas exchange analysis during progressive exercise testing to volitional fatigue or adverse signs/symptoms. Results: Of 2,091 subjects (mean age 59 ± 13 years, with serum creatinine available at baseline), 72% were men, and 61, 33, and 5% were Caucasians, African Americans, and others, respectively. Older age, diabetes, and hypertension were all more frequent with declining eGFR. The Pearson correlation between eGFR and peak VO₂ was 0.22 (p < 0.0001). Age was negatively correlated with both eGFR (r = –0.44, p < 0.0001) and peak VO₂ (r = –0.27, p < 0.0001). The peak VO₂ tended to decline across decreasing levels of eGFR. Individuals with an eGFR <30 ml/min/1.73 m² had, on average, 2.1 high-risk features including peak VO₂ <14 ml/kg/min, age >75 years, diabetes, and functional class 3–4 symptoms. Conversely, those with an eGFR >90 ml/min/1.73 m² had relatively few (1.0) high-risk characteristics. Conclusions: Reduced renal filtration is associated with impaired cardiorespiratory fitness and a clustering of high-risk features in systolic heart failure patients which portend a more complicated course and higher all-cause mortality.

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“…There is a substantial increase in mortality among the obese [1,2,3]. Adiposity is an important determinant for a number of chronic diseases including certain types of cancer [4], cardiovascular disease [5], diabetes [6], chronic kidney disease [7] and respiratory disease [8]. Obesity may also be an important risk factor for allergic diseases [9].…”

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confidence: 99%

Association between Obesity and Atopy in Adults

Chen

Rennie

Cormier

et al. 2010

Int Arch Allergy Immunol

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Background/Aim: Previous literature on the association between obesity and atopy has been inconsistent. The aim of the study was to determine the relationship between obesity and atopic sensitization in adults. Methods: The study included a total of 1,997 residents aged 18–79 years and was conducted in the town of Humboldt, Sask., Canada in 2003. Body mass index (BMI) and waist circumference (WC) were objectively measured. Allergy skin tests were conducted to determine atopic sensitization. Results: Overall, the prevalence of one or more positive skin tests for atopy was 33.3% among those with a BMI of at least 30.0, 28.2% among those with a BMI of 25.0–29.9 and 27.3% among those with a BMI of less than 25 (p = 0.003). The odds ratio for atopy among those with a BMI of at least 30.0 versus those with a BMI of less than 25.0 was 1.51 (95% confidence interval, CI: 1.17, 1.95) after adjustment for sex, age, and other covariates. Stratified by sex, the adjusted odds ratios for obesity versus normal weight were 1.27 (95% CI: 0.73, 1.93) for men and 1.63 (95% CI: 1.18, 2.26) for women. WC was also significantly associated with the prevalence of atopy in both sexes after controlling for covariates. Conclusion: The data demonstrated a significant association between obesity, defined either by BMI or by WC, and atopy.

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Impact of Obesity on Cardiovascular Disease

Cited by 130 publications

References 116 publications

Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats

Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats

Impact of Reduced Kidney Function on Cardiopulmonary Fitness in Patients with Systolic Heart Failure

Association between Obesity and Atopy in Adults

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