Impact of Nutrients on the Hoof Health in Cattle

Langova, Lucie; Novotna, Ivana; Nemcova, Petra; Macháček, Miroslav; Havlicek, Zdenek; Zemanova, Monika; Chrast, Vladimir

doi:10.3390/ani10101824

Cited by 25 publications

(24 citation statements)

References 124 publications

(520 reference statements)

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“…In addition, Zn deficiency in grazing cattle is likely to be rare, as the Zn concentration of most forages tend to be marginally adequate. In a survey of 23 U.S. states, Mortimer et al [28] found that pasture/range grass Zn concentrations averaged 29 ± 9.2 mg/kg with fairly consistent results across four geographic regions of the U.S. (range = 19.5 to 42.9 mg/kg Zn; n = 164 samples).…”

Section: Zincmentioning

confidence: 91%

Trace Mineral Nutrition of Grazing Beef Cattle

Arthington

Ranches

2021

Animals

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The trace mineral requirements of grazing beef cattle are often complicated by different environmental factors, such as the lack of specific trace minerals or the presence of trace mineral antagonists in forage. Nearly every region of the world has specific implications related to trace mineral nutrition of grazing cattle. Since forage is the most significant contributor to trace mineral nutrition, it is important to consider the concentrations of trace minerals and antagonists and how they may impact the performance of cattle consuming them. This review attempts to provide an update on the trace minerals commonly found to be inadequate in forage, supplementation strategies to address deficiency including a discussion on supplemental trace mineral source, and the complications presented by mineral antagonists. Although the review focuses on beef cattle grazing systems of the United States, the information herein is derived from both extensive native range and intensive planted pasture.

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Section: Zincmentioning

confidence: 91%

Trace Mineral Nutrition of Grazing Beef Cattle

Arthington

Ranches

2021

Animals

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“…The pathogenesis of laminitis has not been fully elucidated. It is currently believed that nutrition disorder is one of the main causes [ 7 ]. The disproportion between a high share of rapidly-fermented carbohydrates and low physical effective NDF may cause impaired ruminal health through variation in the VFA concentrations and decreased ruminal fluid pH, which leads to subacute ruminal acidosis (SARA) [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…At present, there is still no effective method for the prevention and treatment of laminitis. Studies have shown that rumen modifiers like monensin can alleviate the severity of laminitis [ 7 , 12 ]. However, there are growing concerns about food safety and drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Angelica polysaccharide attenuates LPS-induced inflammation response of primary dairy cow claw dermal cells via NF-κB and MAPK signaling pathways

Tian

Liu

et al. 2021

BMC Vet Res

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Background Laminitis, an inflammation of the claw laminae, is one of the major causes of bovine lameness, which can lead to enormous economic losses and animal welfare problems in dairy farms. Angelica polysaccharide (AP) is proved to possess anti-inflammatory properties. But the role of AP on inflammatory response of the claw dermal cells has not been reported. The aim of this study was to investigate the anti-inflammatory effects of AP on lipopolysaccharide (LPS)-induced primary claw dermal cells of dairy cow and clarify the potential mechanisms. In the current research, the primary claw dermal cells were exposed to gradient concentrations of AP (10, 50, 100 µg/mL) in the presence of 10 µg/mL LPS. The levels of cytokines and nitric oxide (NO) were detected with ELISA and Griess colorimetric method. The mRNA expressions of TLR4, MyD88 and chemokines were measured with qPCR. The activation of NF-κB and MAPK signaling pathways was detected with western blotting. Results The results indicated that AP reduced the production of inflammatory mediators (TNF-α, IL-1β, IL-6 and NO), downregulated the mRNA expression of TLR4, MyD88 and some pro-inflammatory chemokines (CCL2, CCL20, CXCL2, CXCL8, CXCL10), and suppressed the NF-κB and MAPK signaling pathways evidenced by inhibition of the phosphorylation of IκBα, p65 and ERK, JNK, p38. Conclusions Our results demonstrated that AP may exert its anti-inflammatory effects on claw dermal cells of dairy cow by regulating the NF-κB and MAPK signaling pathways.

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“…Nutrition disorder is one of the main causes of laminitis [6]. A large intake of high-energy feed can lead to the excessive proliferation of rumen microorganisms and lactic acid production, followed with the release of histamine and endotoxins into peripheral blood, resulting in the blood vessels network damage in claw [7].…”

Section: Introductionmentioning

confidence: 99%

“…The preventive and therapeutic strategies for laminitis are concentrated on diet management. Gluconeogenic precursors and rumen modi ers like Monensin, Lasalocid were added to alleviate the severity of laminitis [6,9]. However, there are growing concerns about food safety and drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Angelica Polysaccharide Attenuates LPS-Induced Inflammation Response of Primary Dairy Cow Claw Dermal Cells Via NF-κB and MAPK Signaling Pathways

Tian

Liu

et al. 2021

Preprint

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Background: Laminitis, an inflammation of the claw laminae, is one of the major causes of bovine lameness, which can lead to enormous economic losses and animal welfare problems in dairy farms. Angelica polysaccharide (AP) is proved to possess anti-inflammatory properties. But the role of AP on inflammatory response of the claw dermal cells has not been reported. The aim of this study was to investigate the anti-inflammatory effects of AP on lipopolysaccharide (LPS)-induced primary claw dermal cells of dairy cow and clarify the potential mechanisms. In the current research, the primary claw dermal cells were exposed to gradient concentrations of AP (10, 50, 100 µg/mL) in the presence of 10 µg/mL LPS. The levels of cytokines and nitric oxide (NO) were detected with ELISA and Griess colorimetric method. The mRNA expressions of TLR4, MyD88 and chemokines were measured with qPCR. The activation of NF-κB and MAPK signaling pathways was detected with western blotting.Results: The results indicated that AP reduced the production of inflammatory mediators (TNF-α, IL-1β, IL-6 and NO), downregulated the mRNA expression of TLR4, MyD88 and some pro-inflammatory chemokines (CCL2, CCL20, CXCL2, CXCL8, CXCL10), and suppressed the NF-κB and MAPK signaling pathways evidenced by inhibition of the phosphorylation of IκBα, p65 and ERK, JNK, p38.Conclusions: Our results demonstrated that AP may exert its anti-inflammatory effects on claw dermal cells of dairy cow by regulating the NF-κB and MAPK signaling pathways.

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Impact of Nutrients on the Hoof Health in Cattle

Cited by 25 publications

References 124 publications

Trace Mineral Nutrition of Grazing Beef Cattle

Trace Mineral Nutrition of Grazing Beef Cattle

Angelica polysaccharide attenuates LPS-induced inflammation response of primary dairy cow claw dermal cells via NF-κB and MAPK signaling pathways

Angelica Polysaccharide Attenuates LPS-Induced Inflammation Response of Primary Dairy Cow Claw Dermal Cells Via NF-κB and MAPK Signaling Pathways

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