Impact of Number of Positive Lymph Nodes and Lymph Node Ratio on Survival of Women with Node-Positive Breast Cancer

Tonellotto, Fabiana; Bergmann, Anke; Abrahão, Karen de Souza; Aguiar, Suzana Sales de; Bello, Marcelo; Thuler, Luiz Cláudio Santos

doi:10.5152/ejbh.2019.4414

Cited by 128 publications

(43 citation statements)

References 23 publications

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“…Interestingly, smoking cessation after the diagnosis of breast cancer is likely to reduce the risk of breast mortality. 20,22,23 Schooling data were similar to those of another Brazilian cohort 23 and did not show association with response or survival outcomes. Similarly, a Norwegian cohort 24 also showed no influence of schooling on survival or response, whereas other results suggested that higher level of education may be associated with better survival and quality of life.…”

Section: Discussionsupporting

confidence: 64%

Sociodemographic, Clinical, and Pathological Factors Influencing Outcomes in Locally Advanced Triple Negative Breast Cancer: A Brazilian Cohort

Silva

Paula

Small

et al. 2020

Breast Cancer�(Auckl)

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Objective: To evaluate the association of sociodemographic, clinical, and pathological factors with response and survival in triple negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy (NACT). Methods: Clinical-pathological and sociodemographic data were obtained from medical records of 235 eligible women with TNBC diagnosed between 2010 and 2014 undergoing NACT and surgery at the Brazilian National Cancer Institute. They have been assessed for pathological complete response (pCR), event-free survival (EFS), and overall survival (OS). Both univariate and multivariate Cox regression analyses were performed. Results: The median follow-up was 64.3 months. Most patients had advanced clinical stage (III: 85.1%; cT3/T4: 86.4%; cN1-3: 74.4%) and high-grade tumors (72.1%). Clinical staging (III vs II, adjusted hazard ratio [HR] = 2.95, P = .012) significantly influenced the pCR rate. Alcohol intake negatively influenced EFS (adjusted HR = 1.67, P = .006) and OS (adjusted HR = 1.89, P = .005). Women with pCR showed better EFS (crude HR = 0.15, P < .001) and OS (crude HR = 0.12, P < .001) compared with non-pCR. The ypT (<0.001) and ypN (<0.001) gradually influenced survival outcomes. Conclusion: Clinical stage III were associated with lower response rate and worse survival. Alcohol intake, pCR, and burden of post-NACT residual disease have shown considerable influence on survival outcomes.

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Section: Discussionsupporting

confidence: 64%

Sociodemographic, Clinical, and Pathological Factors Influencing Outcomes in Locally Advanced Triple Negative Breast Cancer: A Brazilian Cohort

Silva

Paula

Small

et al. 2020

Breast Cancer�(Auckl)

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“…Therefore, there is a need for markers related to predicting outcomes in this group of patients. [ 31 , 34 , 35 ]…”

Section: Discussionmentioning

confidence: 99%

Assessment of IGF-1 expression in the peripheral blood of women with recurrent breast cancer

et al. 2020

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Breast cancer is the most common malignancy affecting women worldwide. The insulin-like growth factor 1 (IGF-1) gene encodes a protein responsible for a wide variety of physiological processes, including differentiation and cell proliferation. Despite several studies on tumor tissues, no study has evaluated IGF-1 expression in the peripheral blood of women with recurrent breast cancer. In this cross-sectional study, IGF-1 expression in the peripheral blood of 146 women with breast cancer treated approximately 5 years ago was quantified by quantitative reverse transcription polymerase chain. The women were divided into 2 groups: non-recurrence (n = 85) and recurrence (n = 61). Statistical analysis of the data was performed using ANOVA, Mann–Whitney, and Chi-squared tests ( P < .05). The results showed no significant difference in IGF-1 expression between the non-recurrence and recurrence groups ( P = .988). In the subgroups of patients with lymph node involvement, no statistically significant difference was observed in IGF-1 expression between women with recurrence and those non-recurrence ( P = .113). In patients without lymph node metastases, IGF-1 messenger ribonucleic acid (mRNA) expression levels were significantly higher in the non-recurrence group than in the recurrence group ( P = .019). Furthermore, using the median IGF-1 mRNA expression as the cutoff point, it was obtained a statistically significant difference in tumor histological grade among women with recurrent breast cancer ( P = .042). These data showed significantly higher IGF-1 expression in women without lymph node metastases in the non-recurrence group compared with the recurrence group. In addition, a significant difference was observed in median IGF-1 mRNA expression in relation to tumor histological grade in women with recurrent breast cancer.

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“…São vantagens da administração por esta via: 15,20,21,23,24,25 • 21 foram encontrados dados referentes ao uso de hipodermóclise para recuperação da hidratação em idosos pacientes de uma instituição de longa permanência. Neles, 88% apresentaram melhora do quadro geral e 84% demonstraram melhoras inclusive na cognição.…”

Section: /10unclassified

“…A absorção de medicamentos pela via subcutânea é uniforme e lenta, dependente dos capilares sanguíneos e linfáticos, o transporte ocorre por difusão capilar e perfusão tecidual, sendo assim, essa via elimina o primeiro passo do metabolismo hepático e proporciona uma alta biodisponibilidade. 11,15,20,23,24 Os sítios de punção (Figura 1) devem ser escolhidos considerando as características clínicas de cada paciente, o conforto, a mobilidade e independência do indivíduo. É importante também levar em consideração que, em pacientes desnutridos, pode ocorrer a diminuição da espessura do tecido subcutâneo.…”

Section: /10unclassified

“…O comportamento farmacocinético é semelhante da via intramuscular, porém, com concentração sérica menor e tempo de ação prolongado, evita-se o primeiro passo do metabolismo hepático, possibilitando alta biodisponibilidade e uma concentração sérica estável. 15,16,20,24 A literatura refere que os efeitos adversos da administração de fármacos pela via subcutânea são raros e facilmente evitáveis. Algumas características podem sinalizar a presença de complicações com o acesso e recomenda-se o registro em prontuário de tais reações quando percebidas.…”

Section: Administração De Medicamentos E Fluidosunclassified

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Hipodermóclise: alternativa para infusão de medicamentos em pacientes idosos e pacientes em cuidados paliativos

Figueiró

Milão

2019

PAJAR

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Aim: execute a theoretical review about the use and applicability of subcutaneous therapy and to construct a guide for dilutions and compatibilities between drugs, allowing a safe and effective use by elderly or in need of palliative care patients.Source of data: The research resource used was the search for scientific data in databases such as Lilacs, Medline, Pubmed, and Scielo, to perform a narrative review on the subject, using the terms "Hipodermóclise", "Terapia subcutânea", "Hypodermoclysis" and "Subcutaneous”.Summary of findings: Considering the progressive increase in the elderly population and also in the number of people with chronic or terminal diseases, is important the development of techniques which ensure the comfort and the autonomy of these patients. The Hypodermoclysis or subcutaneous therapy has its therapeutical efficiency proved and it also can be helpful with patients who don´t have the oral way as a possibility for medication administration and hydration. It presents a safe and low-risk way to adverse effects, also acting as relief resource to symptoms such as náusea, vomiting, hard control pain, and dehydration. However, there are some disadvantages such as the impossibility of fast doses and volume adjustment, the limited and infusion speed and the small number of medicine and electrolytes that can be infused.Conclusion: Hypodermoclysis is a safe way of administration, since the clinical characteristics of each patient are considered and, in order to fit the technique, it is necessary to create a database according to the reality of each institution, considering the characteristics of each medicine and the necessary care to promote the quality of life of these patients, so that they can reach their therapeutic goals.

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Impact of Number of Positive Lymph Nodes and Lymph Node Ratio on Survival of Women with Node-Positive Breast Cancer

Cited by 128 publications

References 23 publications

Sociodemographic, Clinical, and Pathological Factors Influencing Outcomes in Locally Advanced Triple Negative Breast Cancer: A Brazilian Cohort

Sociodemographic, Clinical, and Pathological Factors Influencing Outcomes in Locally Advanced Triple Negative Breast Cancer: A Brazilian Cohort

Assessment of IGF-1 expression in the peripheral blood of women with recurrent breast cancer

Hipodermóclise: alternativa para infusão de medicamentos em pacientes idosos e pacientes em cuidados paliativos

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