Impact of nucleotide enriched diets on the production of gilthead seabream, Sparus aurata fingerlings by modulation of liver mitochondrial enzyme activitity, antioxidant status, immune gene expression, and gut microbial ecology

El-Nokrashy, A.M.; El-Banna, R.A.; Edrise, B.M.; Abdel‐Rahim, Mohamed M.; Jover‐Cerdá, Miguel; Tomás‐Vidal, Ana; Prince, Abdelbary; Davies, Simon J.; El‐Haroun, Ehab; Goda, Ashraf

doi:10.1016/j.aquaculture.2021.736398

Cited by 23 publications

(5 citation statements)

References 88 publications

(94 reference statements)

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“…This enhancement could be attributed to charcoal's ability to remove harmful gases and toxins from the gut [16,24], as well as improving the absorption function of intestinal villi and intestinal epithelial cells [12], resulting in increased metabolic activity of digestive enzymes. Both tilapia and sea beam showed similar increases in amylase and lipase levels [65].…”

Section: Discussionmentioning

confidence: 88%

Dietary Wood and Activated Charcoal Improved Ammonium Removal, Heavy Metals Detoxification, Growth Performance, Blood Biochemistry, Carcass Traits, and Histopathology of European Seabass

Elhetawy,

Abdel-Rahim,

Sallam

et al. 2023

Aquaculture Nutrition

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A 120-day growth trial was completed to assess rearing water quality and fish performance in terms of growth, feed efficacy, digestive enzymes, immunity, and antioxidant activity of seabass fed an experimental diet (ED) supplemented with commercial wood charcoal (WC) and activated wood charcoal (AC). Three levels (0, 10, and 20 g) of WC and AC were administered, representing five treatments: control (CD) fish-fed ED without additives, (WC-1) fish-fed ED containing 10 g kg−1 WC, (WC-2) fish-fed ED containing 20 g kg−1 WC, (AC-1) fish-fed ED containing 10 g kg−1 AC, and (AC-2) fish-fed ED containing 20 g kg−1 AC. Three hundred fish (60.12 ± 0.20 g/fish) were stocked in 15 cement tanks (4.0 m × 2.0 m × 1.2 m, water volume 5 m3 each) at 20 fish/tank and a daily feed ration of 3% of body weight. Results revealed significant improvements with increased growth variables (final weight, weight gain, and specific growth rate), decreased FCR, and decreased ammonia levels and heavy metals (Cu, Cd, Fe, Mn, and Zn) content in rearing water, muscle, and liver with fish fed WC and AC supplemented diets. Furthermore, considerable improvements in digestive enzymes, immunity, and antioxidant activity, with enhanced kidneys, liver, intestines, gills, and spleen. Fish fed the WC-1 diet had a higher final weight (171.90 g), better FCR (1.25), and improved internal organs than the other groups.

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Section: Discussionmentioning

confidence: 88%

Dietary Wood and Activated Charcoal Improved Ammonium Removal, Heavy Metals Detoxification, Growth Performance, Blood Biochemistry, Carcass Traits, and Histopathology of European Seabass

Elhetawy,

Abdel-Rahim,

Sallam

et al. 2023

Aquaculture Nutrition

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“…This nucleotide extract is a highly sustainable product as it can be obtained through a fermentation process following a circular bioeconomy approach. To date, there is limited scientific evidence reporting its effects in companion animals [143][144][145][146][147][148][149][150], but prior publications support its use in humans [151,152], aquatic species [153][154][155][156][157][158][159][160][161][162][163], and in livestock species [164][165][166][167][168][169][170][171][172][173][174][175][176][177][178] (Table 1). These studies show a beneficial impact on the immune system and disease resistance, among other beneficial effects, which could serve as background for further studying the usefulness of this product as a tool for modulating the immune response in dogs suffering from diseases such as leishmaniosis, especially given the key role of the immune response in CanL.…”

Section: Immunonutrition and Bioactive Compoundsmentioning

confidence: 99%

Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis

Segarra

2021

Microorganisms

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Leishmaniasis is an emerging, uncontrolled, and neglected zoonotic disease. Climate change is contributing to its ongoing global expansion. The dog is the main reservoir; hence the importance of implementing effective treatment, prevention, and control measures in this animal species to protect public health. However, although the standard treatment for canine leishmaniosis (CanL) is effective, it does not provide full parasitological clearance, and side effects and drug resistance have been described. The host’s immune system plays a key role in the establishment and evolution of leishmaniasis. Dietary nucleotides modulate the immune response and, given their reported efficacy and safety in sick and clinically healthy Leishmania-infected dogs and because they represent a sustainable option with no associated side effects or resistance, they could be included within the prevention, treatment, and control strategies for leishmaniasis. This article briefly summarizes the scientific literature on CanL management, including unresolved issues, and reviews the scientific evidence on immunomodulatory effects of dietary nucleotides in different animal species. It also proposes a CanL management algorithm, including nucleotides. It is concluded that nutritional modulation of the immune response with nucleotides can contribute to better management of leishmaniasis following a One Health approach, especially in the COVID-19 era.

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“…Dietary nucleotide supplementation has important advantages in metabolism, immune function, healthy aging, advanced recovery under stress, and decreased risk of infection during surgery [ 2 ]. The investigations in this domain are very recent [ 3 , 4 , 5 ] and reflect the important role of this theme.…”

Section: Introductionmentioning

confidence: 99%

Polyurethane Microstructures for 2′-Deoxycytidinic Acid Delivery: Preparation and Preliminary Characterization

Jeleriu,

Cavaloiu,

Onofrei

et al. 2024

Medicina

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Background and Objectives: Nucleotide delivery has emerged as a noteworthy research trend in recent years because of its potential utility in addressing a range of genetic defects resulting in the presence of incorrect nucleotides. The primary goals of this research were to create and to characterize polyurethane microstructures, with the aim of utilizing them for nucleotide transport. Materials and Methods: Two samples were prepared using an aliphatic diisocyanate in reaction with a mixture of polyethylene glycol and polycaprolactone diol, where 2′-deoxycytidinic acid was used as the active agent and glycerol 1,2-diacetate was used as an enhancer of the aqueous solubility. The solubility, pH, size distribution, and surface charge of the samples were measured, and encapsulation efficacy and release, cell proliferation, and irritation tests on mouse skin were conducted. Results: The results showed almost neutral acidic–basic structures with a high heterogeneity, and a medium tendency to form clusters with non-cytotoxic and non-irritative potentials. Conclusions: Future research could explore the efficacy of this carrier in delivering other nucleotides, as well as investigating the long-term effects and safety of these microstructures in vivo.

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Impact of nucleotide enriched diets on the production of gilthead seabream, Sparus aurata fingerlings by modulation of liver mitochondrial enzyme activitity, antioxidant status, immune gene expression, and gut microbial ecology

Cited by 23 publications

References 88 publications

Dietary Wood and Activated Charcoal Improved Ammonium Removal, Heavy Metals Detoxification, Growth Performance, Blood Biochemistry, Carcass Traits, and Histopathology of European Seabass

Dietary Wood and Activated Charcoal Improved Ammonium Removal, Heavy Metals Detoxification, Growth Performance, Blood Biochemistry, Carcass Traits, and Histopathology of European Seabass

Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis

Polyurethane Microstructures for 2′-Deoxycytidinic Acid Delivery: Preparation and Preliminary Characterization

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