2016
DOI: 10.1016/j.ejso.2016.02.013
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Impact of novel histopathological factors on the outcomes of liver surgery for colorectal cancer metastases

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Cited by 25 publications
(23 citation statements)
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“…However, the significance of the dimensions of metastatic lesions as prognostic factors in CRLM surgery is controversial. Indeed, two independent studies found that the dimensions of metastases were not associated with local recurrence or 5-year survival rates (24,25). Thus, only the dimensions of metastases cannot be considered an exclusion criterion for surgery, unless they compromise the resection margins or the residual functional parenchyma (24).…”
Section: Discussionmentioning
confidence: 99%
“…However, the significance of the dimensions of metastatic lesions as prognostic factors in CRLM surgery is controversial. Indeed, two independent studies found that the dimensions of metastases were not associated with local recurrence or 5-year survival rates (24,25). Thus, only the dimensions of metastases cannot be considered an exclusion criterion for surgery, unless they compromise the resection margins or the residual functional parenchyma (24).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the specific number of nodules that drives a worse prognosis is actively debated. Whereas most authors consider four or more lesions to be a relative cut‐off associated with a worse prognosis, other investigators have reported more than one, two or even more than seven lesions . The highest level of evidence comes from a meta‐analysis conducted by Smith and McCall, which evaluated 9934 patients who underwent potentially curative therapy (surgical resection and/or ablation).…”
Section: Number Of Liver Metastasesmentioning
confidence: 99%
“…As with tumour number, there is no consensus on the size cut‐off that dictates a worse outcome, and some studies even dispute whether size matters at all. A few studies, most of them evaluating patients treated in the 1980s, have failed to detect any relationship between CRLM size and recurrence or survival . Lesions larger than 50 mm are most commonly associated with a worse prognosis, whereas some studies have utilised 80 mm as the cut‐off size .…”
Section: Size Of Liver Metastasesmentioning
confidence: 99%
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