Impact of Nonosseous Findings on 18F-NaF PET/CT in a Patient with Ductal Breast Carcinoma

Kuyumcu, Serkan; Adalet, İşık; Işık, Emine Göknur; Ünal, Sabri

doi:10.1007/s13139-013-0235-3

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…[ 18 F]NaF is an FDAapproved bone PET imaging agent to define the altered osteogenic activity of bone and is currently widely used in clinical and preclinical studies. [25][26][27][28][29][30][31] Once administered, the 18 F ion infiltrates into the bone matrix, exchanges with hydroxyl groups and forms fluorapatite, which reflects the activity of osteoblasts. Combined [ 18 F]NaF µPET imaging and µCT analysis have been successfully used for monitoring bone regeneration in vivo.…”

Section: Introductionmentioning

confidence: 99%

Multiplexed Molecular Imaging Strategy Integrated with RNA Sequencing in the Assessment of the Therapeutic Effect of Wharton’s Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoporosis

Lu¹,

Chen²,

Ke³

et al. 2021

IJN

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Introduction:Osteoporosis is a result of an imbalance in bone remodeling. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been considered as a potentially promising treatment for osteoporosis. However, the therapeutic effect, genetic alterations, and in vivo behavior of exogenous EVs for osteoporosis in mice models remain poorly understood. Methods: A multiplexed molecular imaging strategy was constructed by micro-positron emission tomography (µPET)/computed tomography (CT), µCT, and optical imaging modality which reflected the osteoblastic activity, microstructure, and in vivo behavior of EVs, respectively. RNA sequencing was used to analyze the cargo of EVs, and the bone tissues of ovariectomized (OVX) mice post EV treatment. Results: The result of [ 18 F]NaF µPET showed an increase in osteoblastic activity in the distal femur of EV-treated mice, and the bone structural parameters derived from µCT were also improved. In terms of in vivo behavior of exogenous EVs, fluorescent dye-labeled EVs could target the distal femur of mice, whereas the uptakes of bone tissues were not significantly different between OVX mice and healthy mice. RNA sequencing demonstrated upregulation of ECMrelated genes, which might associate with the PI3K/AKT signaling pathway, in line with the results of microRNA analysis showing that mir-21, mir-29, mir-221, and let-7a were enriched in Wharton's jelly-MSC-EVs and correlated to the BMP and PI3K/AKT signaling pathways. Conclusion:The therapeutic effect of exogenous WJ-MSC-EVs in the treatment of osteoporosis was successfully assessed by a multiplexed molecular imaging strategy. The RNA sequencing demonstrated the possible molecular targets in the regulation of bone remodeling. The results highlight the novelty of diagnostic and therapeutic strategies of EV-based treatment for osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Multiplexed Molecular Imaging Strategy Integrated with RNA Sequencing in the Assessment of the Therapeutic Effect of Wharton’s Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoporosis

Lu¹,

Chen²,

Ke³

et al. 2021

IJN

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“…F-18 NaF uptake in soft tissues, with macrocalcification of the lesions shown on CT images, were reported in intracranial meningiomas, in metastases of a patient with ovarian carcinoma, a patient with an infiltrating ductal carcinoma of the breast, and a patient with osteosarcoma [1][2][3][4]. Although presence of microcalcification was not proved; accumulation of F-18 NaF in the metastatic brain lesion with no visible calcification on the CT in a patient with ductal breast carcinoma has also been reported [5]. The multiple hypodense metastatic lesions detected on CT images in our c a s e w e r e a l s o n o t m a c r o c a l c i f i e d .…”

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confidence: 99%

Microcalcified Hepatic Metastases Incidentally Detected on F-18 NaF PET/CT in a Patient with Prostate Cancer

Aktaş

Sarıkaya

Can

et al. 2016

Nucl Med Mol Imaging

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F-18 NaF PET/CT evaluation has gained importance in recent years. Achievements from F-18 NaF PET/CT are: higher sensitivity of positron imaging, higher target background ratio with higher tracer accumulation in bone hydroxyapatite and higher specificity through CT correlation. These properties have also given directions to new research fields based on imaging microcalcifications, very recently. A limited number of cases have reported the F-18 NaF uptake in macrocalcified soft tissue metastases. Although the presence of microcalcification was not proved; accumulation of F-18 NaF in the metastatic brain lesion with no visible calcification on the CT, in a patient with ductal breast carcinoma has also been reported. Herein we present a patient with microcalcified hepatic metastasis of prostate cancer incidentally detected on F-18 NaF PET/CT which was confirmed with histochemical staining.

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“…Lesions containing dystrophic or microscopic calcification or calcified visceral metastases can show focal uptake of 18F-NaF. [ 7 8 9 10 ] Tc-99m methylene diphosphonate uptake has been reported in ovarian carcinoma and its soft tissue metastases. [ 11 ] In literature, there is one case report of F-18 fluoride uptake in calcified extraosseous metastases from ovarian papillary serous adenocarcinoma.…”

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confidence: 99%

Calcified peritoneal metastasis identified on 18F-fluoride positron emission tomography/computed tomography: Importance of extraosseous uptake of F-18 fluoride

et al. 2016

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F-18 NaF positron emission tomography/computed tomography (PET/CT) is used for the evaluation of malignant and nonmalignant osseous disease. Extraosseous uptake of 18 fluoride-NaF has been observed in the arterial vasculature, gastrointestinal tract, and genitourinary tract. We describe a case of a woman with carcinoma of unknown primary in whom F-18 NaF PET/CT showed tracer uptake in the calcified peritoneal metastasis. Extraosseous findings on F-18 NaF PET/CT, though rare, may be visualized and may result in important management changes.

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Impact of Nonosseous Findings on 18F-NaF PET/CT in a Patient with Ductal Breast Carcinoma

Abstract: 18 F-NaF was used as a bone-seeking PET tracer for skeletal imaging until the introduction of the widely available 99m

Cited by 6 publications

References 9 publications

Multiplexed Molecular Imaging Strategy Integrated with RNA Sequencing in the Assessment of the Therapeutic Effect of Wharton’s Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoporosis

Multiplexed Molecular Imaging Strategy Integrated with RNA Sequencing in the Assessment of the Therapeutic Effect of Wharton’s Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoporosis

Microcalcified Hepatic Metastases Incidentally Detected on F-18 NaF PET/CT in a Patient with Prostate Cancer

Calcified peritoneal metastasis identified on 18F-fluoride positron emission tomography/computed tomography: Importance of extraosseous uptake of F-18 fluoride

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