Impact of nonalcoholic fatty liver disease-related metabolic state on depression

Ntona, Smaragda; Papaefthymiou, Apostolis; Kountouras, Jannis; Gialamprinou, Dimitra; Kotronis, Georgios; Boziki, Marina; Polyzos, Stergios A.; Tzitiridou, Maria; Chatzopoulos, Dimitrios; Thavayogarajah, Tharshika; Gkolia, I; Ntonas, Georgios; Vardaka, Elisabeth; Doulberis, Michael

doi:10.1016/j.neuint.2023.105484

Cited by 5 publications

(5 citation statements)

References 143 publications

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“…It is widely acknowledged that liver steatosis, characterized by the accumulation of fat in liver cells, often leads to a proinflammatory environment and activates microglial cells [ 67 ]. Moreover, it has been suggested that liver steatosis can also trigger a systemic hyperinflammatory state, which can result in damage to the PFC—a phenomenon frequently observed in depression [ 68 ]. Our results showed that the morphology of liver cells was significantly altered in CUMS-induced depression in rats and that the increase in the expression of CD68, upregulation of P2X7R/NLRP3/IL-1β expression, and increase in the release of proinflammatory cytokine IL-1β were all improved by EA as well as the intraperitoneal injection of BBG.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Alleviates Depressive-like Behavior by Modulating the Expression of P2X7/NLRP3/IL-1β of Prefrontal Cortex and Liver in Rats Exposed to Chronic Unpredictable Mild Stress

et al. 2023

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Depression is a complex clinical disorder associated with poor outcomes. Electroacupuncture (EA) has been demonstrated to have an important role in both clinical and pre-clinical depression investigations. Evidence has suggested that the P2X7 receptor (P2X7R), NLRP3, and IL-1β play an important role in depressive disorder. Our study is aimed at exploring the role of EA in alleviating depression-like behaviors in rats. We therefore investigated the effects of EA on the prefrontal cortex and liver of rats subjected to chronic unpredictable mild stress (CUMS) through behavior tests, transmission electron microscopy, Nissl staining, HE staining, immunohistochemistry and Western blotting. Five weeks after exposure to CUMS, Sprague-Dawley (SD) rats showed depression-like behavior. Three weeks after treatment with brilliant blue G (BBG) or EA, depressive symptoms were significantly improved. Liver cells and microglia showed regular morphology and orderly arrangement in the BBG and EA groups compared with the CUMS group. Here we show that EA downregulated P2X7R/NLRP3/IL-1β expression and relieved depression-like behavior. In summary, our findings demonstrated the efficacy of EA in alleviating depression-like behaviors induced by CUMS in rats. This suggests that EA may serve as an adjunctive therapy in clinical practice, and that P2X7R may be a promising target for EA intervention on the liver–brain axis in treatment of depression.

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Section: Discussionmentioning

confidence: 99%

Electroacupuncture Alleviates Depressive-like Behavior by Modulating the Expression of P2X7/NLRP3/IL-1β of Prefrontal Cortex and Liver in Rats Exposed to Chronic Unpredictable Mild Stress

et al. 2023

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“…Compared to the non-NAFLD population, the risk of developing depression is 13% higher in individuals with NAFLD, and the risk of NAFLD is signi cantly increased by 46% in people with depression [16]. NAFLD and depression share some common risk factors such as obesity, metabolic syndrome, and T2D [17]. Adiposity and dysregulation of adipose tissue lipid metabolism in NAFLD are thought to be involved in the pathogenesis of depression, suggesting an important role for obesity and adipose tissue function in the liver-brain axis in NAFLD [18, 19.…”

Section: Introductionmentioning

confidence: 99%

Association between Weight-Adjusted Waist Index and Depression in NAFLD: The Modulating Roles of Sex and BMI

Zhang,

Wang,

Xie

et al. 2024

Preprint

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Background The Weight-Adjusted Waist Index (WWI) is a novel indicator of obesity that accurately reflects body composition. However, the association between WWI and depression in patients with non-alcoholic fatty liver disease (NAFLD) remains unclear. This study aims to explore this relationship through a nationally representative cross-sectional analysis. Methods This study included adult participants diagnosed with NAFLD from NHANES 2017–2020. WWI was calculated as the waist circumference (cm) divided by the square root of body weight (kg). NAFLD diagnosis relied on vibration-controlled transient elastography (VCTE) with a controlled attenuation parameter (CAP) exceeding 248 dB/m to indicate hepatic steatosis. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), with scores ≥ 10 indicating the presence of major depression. Results After adjusting for all covariates, a significant positive association was found between WWI and depression in NAFLD (OR = 1.725, 95% CI: 1.442–2.063, p < 0.00001), with a dose-response relationship indicated by restricted cubic spline analysis. The association was stronger in men and lean NAFLD patients. Adjusting further for BMI did not alter these findings (OR = 1.643, 95% CI: 1.357–1.989, p < 0.00001). BMI's association with depression was negated after adjusting for WWI. Conclusions WWI had a positive association with depression in NAFLD, independent of BMI. This association was more pronounced in men and lean NAFLD. These findings suggest that WWI may be a novel predictor of depression in NAFLD and potentially valuable in depression prevention.

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“…MAFLD, put forward by The International Fatty Liver Panel as a fresh nomenclature ( 2 ) in April 2020, presents a more comprehensive and precise understanding of the liver through various tests, such as biopsies, imaging scans, and blood markers, as well as accompanying health issues like obesity, diabetes, and metabolic disorders. MAFLD is commonly associated with a plethora of extra-hepatic conditions, such as diabetes, cardiovascular disease, and depression ( 3 , 4 ), which makes it a high-risk factor for health. There is currently no approved pharmacologic treatment for MAFLD; hence, it is important to better understand the modifiable risk factors for it.…”

Section: Introductionmentioning

confidence: 99%

Higher serum chromium level may be associated with the presentation of depression in patients with metabolic dysfunction-associated fatty liver disease: evidence from NHANES survey

Li,

Xia,

Jiang

et al. 2024

Front. Psychiatry

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BackgroundDepressive symptoms are frequently observed in patients with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD), a prevalent metabolic disorder that affects many individuals. It is not yet clear whether there is an association between serum chromium levels and depression.ObjectiveThe purpose of this research was to explore the association between serum chromium level and the manifestation of depression among patients with MAFLD.MethodsThe selection of 1837 patients diagnosed with MAFLD was based on data obtained from the 2017-2018 National Health and Nutrition Examination Survey (NHANES) database in this research. The Patient Health Questionnaire-9 (PHQ-9) was employed to evaluate the severity of depression. The researchers utilized logistic regression models that were weighted for multiple variables to investigate the association between depression and serum chromium levels.ResultsIn our study, we found that 8.98% of US adults with MAFLD were suffering from depression at the time of evaluation. In the logistic regression model, serum chromium levels showed an inverse association with depression (OR=0.82, 95%CI: 0.69-0.96; p=0.016), this relationship remained after adjusting for fully confounding factors (OR=0.83, 95%CI: 0.71-0.97; p=0.021), subgroup analyses showed that the association between serum chromium levels and depression existed in relatively high-prevalence of depression groups.ConclusionPatients diagnosed with MAFLD have a greater likelihood of experiencing depression, whereas individuals with higher levels of serum chromium are less likely to suffer from depression, and this association persists even after adjusting for other factors. These findings indicate supplementing chromium may be a viable treatment for their depressive symptoms.

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Impact of nonalcoholic fatty liver disease-related metabolic state on depression

Cited by 5 publications

References 143 publications

Electroacupuncture Alleviates Depressive-like Behavior by Modulating the Expression of P2X7/NLRP3/IL-1β of Prefrontal Cortex and Liver in Rats Exposed to Chronic Unpredictable Mild Stress

Electroacupuncture Alleviates Depressive-like Behavior by Modulating the Expression of P2X7/NLRP3/IL-1β of Prefrontal Cortex and Liver in Rats Exposed to Chronic Unpredictable Mild Stress

Association between Weight-Adjusted Waist Index and Depression in NAFLD: The Modulating Roles of Sex and BMI

Higher serum chromium level may be associated with the presentation of depression in patients with metabolic dysfunction-associated fatty liver disease: evidence from NHANES survey

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