Impact of Non-Alcoholic Fatty Liver Disease on the Clinical Course of Crohnʼs Disease Patients Followed at a Tertiary Care IBD Referral Center

Young, Steven; Walker, Caroline; Orr, Jordan; Fitzmorris, Paul; Xie, Fenglong; Malik, Talha A.; Kodali, Sudha

doi:10.14309/00000434-201510001-01933

Cited by 2 publications

(7 citation statements)

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“…McHenry et al . documented the presence of NAFLD in 38% of patients with CD [27], while other studies included in our analysis reported significantly lower numbers of NAFLD among IBD patients [18,23–26]. This variability in prevalence rate is most likely attributed to differences in sample sizes, population selection, as well as NAFLD diagnostic criteria used across studies.…”

Section: Discussionmentioning

confidence: 65%

“…Four studies included only inpatients with administrative data obtained from the Nationwide Readmissions Database [18,19,26] and the Nationwide Inpatient Sample Database (NIS) [25]. Three studies followed patients from initial outpatient settings, with their respective cohorts originating from US-based IBD centers [23,24,27]. Diagnostic codes that ascertain IBD-relatedness as a reason for admission are provided in Supplementary Material 2, Supplemental digital content 1, http://links.lww.com/EJGH/A891.…”

Section: Resultsmentioning

confidence: 99%

“…Only one cohort included and evaluated CD and UC patients separately (n = 18 170 CD and n = 9866 UC patients) [19]. Three articles included only patients with CD (n = 216 206) [18,23,27]. Additional patient characteristics are listed in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Four articles diagnosed NAFLD in their cohorts based on ICD coding [18,19,25,26] and two articles diagnosed the disease based on imaging findings [24,27]. Only one study failed to specify how NAFLD was diagnosed in its patient population [23]. Only one study reported NAFLD severity in its cohort [27] as provided in Table 3.…”

Section: Resultsmentioning

confidence: 99%

“…Even if the study quality was good, the overall certainty of evidence was limited, principally due to risk of bias, and both paucity and variability in the presentation of data that prevented quantitative summary analysis. Given the fact that four studies included only inpatients [18,19,26] whereas the other three evaluated outpatients [23,24,27], we opted to analyze the respective data separately. Another important limitation relates to the fact that the seven articles obtained reported their results after adjusting for differing confounding variables, further limiting the comparability of results.…”

Section: Discussionmentioning

confidence: 99%

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The impact of nonalcoholic fatty liver disease on inflammatory bowel disease-related hospitalization outcomes: a systematic review

Boustany

Rahhal

Mitri

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Evidence suggests that patients with inflammatory bowel disease are at higher risk of developing nonalcoholic fatty liver disease (NAFLD). However, there is limited information currently available on how NAFLD may affect the clinical course of IBD. Thus, we conducted a systematic review to evaluate the impact of NAFLD on IBD-related hospitalization outcomes. All observational studies assessing IBD-related hospitalization outcomes in patients with NAFLD were included. Exclusion criteria were studies published in languages other than English or French, or those involving pediatric population. Outcomes included IBD-related hospitalization and readmission rates, need for surgery, length of stay, inpatient mortality, and costs. Overall, 3252 citations were retrieved and seven studies met the inclusion criteria (1 574 937 patients); all were observational, of high quality, and originated in the United States. Measurable outcomes reported in these studies were few and with insufficient similarity across studies to complete a quantitative assessment. Only one study reports NAFLD severity. Two studies suggested a higher rate of hospitalization for patients with both NAFLD and IBD compared to IBD alone (incidence rate ratio of 1.54; 95% confidence interval: 1.33–1.79). This is the first systematic review to date that evaluates any possible association of NAFLD with IBD-related hospitalization outcomes. Despite the paucity and low quality of available data, our findings indicate that NAFLD may be associated with worse outcomes amongst IBD patients (especially Crohn’s disease). Further and higher certainty of evidence is needed for better characterization of such clinical impact.

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Section: Discussionmentioning

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

The impact of nonalcoholic fatty liver disease on inflammatory bowel disease-related hospitalization outcomes: a systematic review

Boustany

Rahhal

Mitri

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Systematic Review and Meta-Analysis: Prevalence of Non-Alcoholic Fatty Liver Disease and Liver Fibrosis in Patients with Inflammatory Bowel Disease

Navarro,

Gutiérrez-Ramírez,

Tejera-Muñoz

et al. 2023

Nutrients

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Background: Non-alcoholic fatty liver disease (NAFLD) is a common concomitant condition in patients with inflammatory bowel disease (IBD). We aim to assess the magnitude of this association. Methods: We searched MEDLINE, EMBASE and Scopus libraries for the period up to February 2023 to identify studies reporting cohorts of IBD patients in which NALFLD was evaluated. Results: Eighty-nine studies were analyzed. The overall prevalence of NAFLD was 24.4% (95%CI, 19.3–29.8) in IBD, 20.2% (18.3–22.3) in Crohn’s disease and 18.5% (16.4–20.8) for ulcerative colitis. Higher prevalence was found in male compared to female patients, in full papers compared to abstracts, and in cross-sectional studies compared to prospective and retrospective ones. The prevalence of NAFLD in IBD has increased in studies published from 2015 onwards: 23.2% (21.5–24.9) vs. 17.8% (13.2–22.9). Diagnostic methods for NAFLD determined prevalence figures, being highest in patients assessed by controlled attenuation parameter (38.8%; 33.1–44.7) compared to ultrasonography (28.5%; 23.1–34.2) or other methods. The overall prevalence of fibrosis was 16.7% (12.2–21.7) but varied greatly according to the measurement method. Conclusion: One-quarter of patients with IBD might present with NAFLD worldwide. This proportion was higher in recent studies and in those that used current diagnostic methods.

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Impact of Non-Alcoholic Fatty Liver Disease on the Clinical Course of Crohnʼs Disease Patients Followed at a Tertiary Care IBD Referral Center

Cited by 2 publications

References 0 publications

The impact of nonalcoholic fatty liver disease on inflammatory bowel disease-related hospitalization outcomes: a systematic review

The impact of nonalcoholic fatty liver disease on inflammatory bowel disease-related hospitalization outcomes: a systematic review

Systematic Review and Meta-Analysis: Prevalence of Non-Alcoholic Fatty Liver Disease and Liver Fibrosis in Patients with Inflammatory Bowel Disease

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