Impact of Nocturnal Heartburn on Quality of Life, Sleep, and Productivity: The SINERGE Study

Abstract

The aim of the SINERGE study was to assess the impact of nocturnal heartburn on quality of life, sleep, and productivity. Ambulatory patients >/=18 years old and classified as defined cases of nocturnal heartburn (n=337), nonnocturnal heartburn (n=139), uncontrolled hypertension (n=198), and symptomatic depression (n=104) were included in this cross-sectional study. Information on age, gender, body mass index, and comorbidity was collected and the following validated questionnaires were applied: SF-12, Pittsburgh Sleep Quality Index, and Work Productivity and Activity Impairment questionnaire. The prevalence of primary care consultation for heartburn and nocturnal heartburn was 4.7% and 1.9%, respectively. Health-related quality of life, sleep, and productivity were significantly impaired in patients with frequent nocturnal heartburn symptoms as compared with those of the patients without nocturnal symptoms or patients with hypertension. Nocturnal heartburn poses a considerable burden for the sufferer because of the impact on quality of life, sleep, and daily activities.

The Effect of Dexlansoprazole MR on Nocturnal Heartburn and GERD-Related Sleep Disturbances in Patients With Symptomatic GERD

“…Furthermore, this treatment was more eff ective in reducing the number of work hours missed due to GERD-related sleep disturbances. Th ese results are not unexpected when one considers the connection between repeated lack of sleep during the night and daytime sleepiness ( 9 ), as well as reduced HRQoL and work productivity ( 11 negative impact of nocturnal GERD on HRQoL and work productivity is well recognized ( 7,8,10 ). A recent survey of over 600 GERD patients on various PPI therapies found that the majority of patients continued to experience heartburn, with 83 % experiencing nocturnal symptoms and almost a quarter of these patients reporting severe or very severe nocturnal symptoms ( 32 ).…”

“…Among those reporting GERD symptoms, up to 89 % report nocturnal symptoms ( 1,4 -6 ), resulting in impairment in health-related quality of life (HRQoL) and signifi cantly worse sleep quality ( 7,8 ). Because continued sleep disruption leads to increased daytime sleepiness ( 9 ), nocturnal heartburn can reduce productivity while patients are present at work, as well as reduce function when performing normal daily activities ( 7,8,10,11 ). Th e continued presence of nocturnal heartburn despite routine medical treatment is strongly associated with decreases in HRQoL ( 12 ).…”

Validación del Cuestionario sobre Alteraciones de Reflujo (RDQ) y de la Escala de Impacto de la Enfermedad por Reflujo Gastroesofágico (GIS) para población española

“…Sin embargo, en otros estudios, que definen la enfermedad como la presencia de pirosis o regurgitación ácida de cualquier intensidad o frecuencia, se ha comunicado una mayor prevalencia anual de ERGE en España, del 31,6% 3 . La presencia de síntomas de ERGE se asocia a una disminución de la calidad de vida 4-7 y de la productividad 6,8,9 , y a un elevado consumo de recursos sanitarios en forma de consultas médicas, estudios de diagnóstico por la imagen y endoscopias 9 . Cuanto más graves son los síntomas de la ERGE menor es la calidad de vida y la productividad, y mayor es la utilización de recursos sanitarios 10 .…”

The strategy for choosing a new-generation proton pump inhibitor dexlansoprazole in the treatment of gastroesophageal reflux disease

“…Однако зарубежные данные свидетельствуют о нали-чии ночных симптомов в 89% случаях среди пациентов с симптомами ГЭРБ [34][35][36][37]. В результате этого снижается качество жизни и значительно ухудшается качество сна, приводящее к дневной сонливости, снижению работоспо-собности и ухудшению способности выполнять обычные повседневные обязанности [38][39][40][41]. В проведенном под эгидой Американской гастроэнтерологической ассоциа-ции исследовании Gallup показано, что большинство пациентов с ГЭРБ не были полностью удовлетворены при-нимаемыми безрецептурными или выписанными им пре-паратами из-за сохраняющихся ночных симптомов [37].…”