Impact of nicotine-induced green tobacco sickness on DNA damage and the relation with symptoms and alterations of redox status in tobacco farmers

Alves, Jodel; Silva, Fernanda R. Da; Kahl, Vivian Francília Silva; Reyes, Juliana; Lima, Elisiane; Abreu, Marina B.; Thiesen, Flávia Valladão; Santos, Denise Leal dos; Salvador, Mirian; Branco, Cátia Santos; Nersesyan, Armen; Knasmüller, Siegfried; Silva, Juliana da

doi:10.1016/j.ecoenv.2020.111397

Cited by 11 publications

(8 citation statements)

References 46 publications

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“…Smoking and smoking cessation are both slow processes. Especially when smoking for a long time, nicotine and other harmful substances (40) gradually infringe upon the body of smokers, which not only makes smokers dependent on it, but also causes grievous damage (41)(42)(43). Hence, it is difficult for us to imagine the secondary harm caused by relapse.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Relapse After Smoking Cessation: Results in China Family Panel Studies From 2010 to 2018

Yu²,

Du³

et al. 2022

Front. Public Health

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BackgroundTobacco use is still highly prevalent globally in spite of the tobacco control efforts made by the governments. In view of the harm of smoking and relapse after smoking cessation, the purpose of this study is to establish a competitive risk model to determine potential risk factors for smoking relapse.MethodsThe population-based cohort of ex-smokers over the age of 18 years was obtained from the China Family Panel Studies (CFPS) database from 2010 to 2018. Competing risk models were conducted to identify the risk factors for relapse.ResultsA total of 1,019 subjects were included in this study, of which 311 (30.52%) subjects relapsed during the follow-up period. A multivariate analysis indicated that age < 40 years [hazard ratio (HR) 19.142; 95% CI: 10.641–34.434, p < 0.01], cohabitation (HR: 1.422; 95% CI: 1.081–1.87, p = 0.01), and often depression [HR 1.422; 95% CI, (1.081–1.87), p = 0.01] were associated with a great risk of relapse while the age of quitting smoking < 60 years (HR: 0. 436; 95% CI: 0.229–0.831, p < 0.01) and joining the Chinese Communist Party (CCP) (HR 0.611; 95% CI: 0.397–0.939, p = 0.03) were reduced risk factors for relapse.ConclusionsApproximately 3 in 10 ex-smokers were observed to relapse. There are various risk factors for relapse as well. In the face of such a serious situation, it is urgent to take action to control smoking.

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Section: Discussionmentioning

confidence: 99%

Risk Factors of Relapse After Smoking Cessation: Results in China Family Panel Studies From 2010 to 2018

Yu²,

Du³

et al. 2022

Front. Public Health

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“…Occupational health risk are potential dangers and hazards that exist in the workplace that can have a negative impact on the health and welfare of workers (International Labour Organization, 2019). The activities of tobacco workers which include sowing, fertilizing flower buds, spraying pesticides, or herbicides, harvesting, and separating leaves will cause health problems for tobacco farmers (Alves et al, 2020). One disease that can occur is Green Tobacco Sickness.…”

Section: Introductionmentioning

confidence: 99%

Overview of the Occurrence of Green Tobacco Sickness (GTS) in Tobacco Farming Areas: A Literature Review

Kurniyawan

2023

JLT

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One of the occupational health risks of tobacco farmers is Green Tobacco Sickness (GTS). The large number of Green Tobacco Sickness incidents nationally and internationally experienced by green tobacco farmers has led to a great deal of research being conducted to determine the process of occurrence of the disease, the impact on health and other fields, the prevention, and management of this disease. The method used in this literature review is to re-expose published information and then return briefly without reducing the essence of the topic of discussion. The journal used in making literature reviews was obtained from 3 database source, namely Google Scholar, Pubmed, and Science Direct published between 2018-2021. The aim of the study was to describe the incidence of Green Tobacco Sickness in the farmers in the green tobacco farming area. The conclusion of this study is based on some research, it is stated that tobacco farmers already understand about GTS and the symptoms that can arise due to GTS. However, several other studies have shown that the educational level of tobacco farmers is included in the low category where this can affect workers to protect or prevent diseases caused by the work they do. Based on these results, it is hoped that there will be a role for nurses who can support the reduction of Green Tobacco Sickness (GTS) cases such as counseling to green tobacco farmers about the dangers of GTS and prevention efforts such as using good and correct PPE.

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“…A study shows that smokers exposed to the same amount of tobacco are more likely to become addicted if the body absorbs more nicotine, resulting in the decline of smokers' ability to quit smoking 4 . Exposure to nicotine, a precursor of cotinine in tobacco, can lead to green tobacco sickness and DNA damage 5 . Cotinine can also affect the reproductive function of men and women and increase the risk of cancer in offspring 6 .…”

Section: Introductionmentioning

confidence: 99%

Association between Metabolite Cotinine and Volatile Organic Compounds (VOCs) Serum Levels in Adults Living with HIV, HBV, or HCV: NHANES 2005–2018

Yang

Zhang

Lin

et al. 2022

Preprint

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Objectives: To identify the unilateral effect of VOCs on cotinine metabolism. Methods: Measurements of 13,652 participants included sociodemographic characteristics and serological indicators (VOCs and cotinine). Correlation between VOCs and cotinine and the effect of VOCs on cotinine metabolism were analyzed by Spearman analysis and multivariable logistic regression analysis. Results: Among smokers infected with HIV | HBV | HCV with the largest exposure dose to tobacco, the intensity of the association between VOCs and cotinine was the strongest. High concentrations of 1,2-Dichlorobenzene (OR: 1.101, CI: 1.069–1.134), Benzene (OR: 1.354, CI: 1.123–1.632), 2,5-Dimethylfuran (OR: 1.054, CI: 1.027–1.082) and Nitrobenzene (OR: 1.347, CI: 1.039–1.746) and low concentration of Carbon Tetrachloride (OR: 0.760, CI: 0.661–0.873) in blood might be independent risk factors leading to the increase of serum metabolite cotinine. Conclusions: The influence intensity of four VOCs (including 1,2-dichlorobenzene, benzene, carbon tetrachloride, 2,5-dimethylfuran and nitrobenzene) on serum cotinine metabolism has a dose-response relationship, that is, the higher the tobacco exposure, the stronger the influence intensity. In addition, this study used molecular epidemiology to indirectly provide new ideas and views on the harm of smoking for smokers.

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Impact of nicotine-induced green tobacco sickness on DNA damage and the relation with symptoms and alterations of redox status in tobacco farmers

Cited by 11 publications

References 46 publications

Risk Factors of Relapse After Smoking Cessation: Results in China Family Panel Studies From 2010 to 2018

Risk Factors of Relapse After Smoking Cessation: Results in China Family Panel Studies From 2010 to 2018

Overview of the Occurrence of Green Tobacco Sickness (GTS) in Tobacco Farming Areas: A Literature Review

Association between Metabolite Cotinine and Volatile Organic Compounds (VOCs) Serum Levels in Adults Living with HIV, HBV, or HCV: NHANES 2005–2018

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