Impact of new radiotherapy modalities on the surgical management of cancer of the esophagus and cardia

Flores, Albino D.; Nelems, Bill; Evans, K E; Hay, John; Stoller, J L; Jackson, Stewart M.

doi:10.1016/0360-3016(89)90139-9

Cited by 53 publications

(20 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Intraluminal radiotherapy (brachytherapy) is not new, but recent technical advances allowing HDR brachytherapy may offer several advantages over the conventional technique of external irradiation alone: better local control, reduction of treatment time and, when given before external radiotherapy, rapid improvement of dysphagia. Several studies (Hyden et al, 1988;Petrovich et al, 1991;Sur et al, 1992) (Flores et al, 1989;Hishikawa et al, 1991).…”

Section: Resultsmentioning

confidence: 99%

“…Since the review of the literature on the role of radiotherapy by Earlam and Cunho-Melo (1980), radiation techniques have changed, especially after brachytherapy was in favour again when remote control techniques became available, as described by Rowland and Pagliero (1985); followed by others (Petrovich et al, 1991;Smalley et al, 1994). In most studies (Caspers et al, 1993;Flores et al, 1989;Gaspar, 1994;Hishikawa et al, 1991;Hyden et al, 1988;Sur et al, 1992), intracavitary irradiation has been used as a booster following external radiotherapy, which has the advantage of delivering a high dose to a small tumour volume.…”

mentioning

confidence: 99%

“…Aiming at optimal tumour regression and improved quality of life, at the cost of minimal side-effects, we based our regimen on the two largest series in the literature: that of Flores et al (1989), who combined a short course of EBRT (40 Gy over 3 weeks) with medium dose rate brachytherapy (15 Gy), and the wide experience of Hishikawa et al (1991) using high dose rate (2 x 6 Gy) in addition to EBRT (60 Gy over 6 weeks). With regard to dysphagia and the generally short life expectancy, we applied 10 Gy HDR brachytherapy before a short duration radiotherapy scheme, 40 Gy over 3 weeks EBRT.…”

mentioning

confidence: 99%

See 2 more Smart Citations

High dose rate brachytherapy before external beam irradiation in inoperable oesophageal cancer

Taal

Aleman²,

Koning³

et al. 1996

Br J Cancer

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

High dose rate brachytherapy before external beam irradiation in inoperable oesophageal cancer

Taal

Aleman²,

Koning³

et al. 1996

Br J Cancer

View full text Add to dashboard Cite

“…Syed et al [ 161 reported excellent palliation of symptoms in 8 1 % of patients using intraluminal radiation and 5-FU infusion. Flores et al [27] achieved normal swallowing for solids in 56% patients with external radiotherapy and intraluminal radiotherapy. George [ 191 reported excellent improvement in dysphagia in 50% and fair to good improvement in another 40% patients after external radiation and intracavitary radium therapy.…”

Section: Discussionmentioning

confidence: 97%

The role of intraluminal radiotherapy and concurrent 5‐fluorouracil infusion in the management of carcinoma esophagus: A pilot study

Dinshaw

Sharma

Pendse

et al. 1991

Journal of Surgical Oncology

View full text Add to dashboard Cite

Fifty patients with carcinoma of the esophagus were entered in a randomized pilot study to test the efficacy of intraluminal radiotherapy (ILRT) and concurrent 5-fluorouracil (5-FU) infusion. The median age was 65 years, with 80% having middle third lesions; in 62%, the lesions were longer than 5 cm. After external beam therapy of 50 Gy in 5 weeks, patients were randomized to receive chemotherapy. Significant improvement in dysphagia was recorded in 76% patients with complete response in 47 cases ranging from 6 to 27 months. The overall survival at 2 years was 15% with ILRT alone versus 22% with ILRT plus 5-FU infusion.

show abstract

“…Radiotherapy in combination with surgery positively affects functional status, swallowing, weight, and pain in patients with cancer of the esophagus and cardia (61).…”

Section: Gastrointestinal Cancermentioning

confidence: 99%

Quality of Life

Cj¹

1996

Acta Oncologica

View full text Add to dashboard Cite

Summary and ConclusionsThis synthesis of the literature on the quality of life in relation to radiotherapy is based on 78 scientific articles. including 12 randomized studies, 25 prospective studies, and 20 retrospective studies. These studies involve 9 884 patients.Radiotherapy is often organ-preserving, which inherently promotes a better quality of life. Many quality of life aspects related to radiotherapy have been studied, but seldom by prospective randomized studies that compare radiotherapy t o other treatment (eg, surgery or chemotherapy). Radiotherapy involves numerous physical and psychological symptoms, mainly during the course of treatment. Examples include skin irritation and fatigue. Radiotherapy directed at the brain has delayed effects. in children treatment carries a substantial risk for lowering the IQ. The risk for encephalopathy in adults is probably underestimated. Patients with cancer in the head and neck may cxperience adverse side effects in the irradiated area long after the conclusion of radiotherapy. There are no confirmed differences in quality of life between breast cancer patients receiving adjuvant radiotherapy and those receiving chemotherapy. Impotency problems and urinary incontinence appear following radical surgery and radiotherapy for prostate cancer. The risk for delayed complications is low after radiotherapy for testicular cancer. Patients receiving radiotherapy for gynecologic cancers are often troubled by local side effects long after the conclusion of treatment.

show abstract

Impact of new radiotherapy modalities on the surgical management of cancer of the esophagus and cardia

Cited by 53 publications

References 13 publications

High dose rate brachytherapy before external beam irradiation in inoperable oesophageal cancer

High dose rate brachytherapy before external beam irradiation in inoperable oesophageal cancer

The role of intraluminal radiotherapy and concurrent 5‐fluorouracil infusion in the management of carcinoma esophagus: A pilot study

Quality of Life

Contact Info

Product

Resources

About