Impact of Neutrophil to Lymphocyte Ratio (NLR) Index and Its Periprocedural Change (NLR<sub>Δ</sub>) for Percutaneous Coronary Intervention in Patients With Chronic Total Occlusion

Li, Chenguang; Zhang, Feng; Shen, Yi; Xu, Ran; Chen, Zhangwei; Dai, Yi; Lu, Hao; Chang, Shufu; Qian, Juying; Wang, Xiangfei

doi:10.1177/0003319716649112

Cited by 25 publications

(28 citation statements)

References 45 publications

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“…CD8+ T cells promote reendothelialization and inhibit neointima formation following arterial injury in mice [ 26 ]. Clinical studies indicate that the neutrophil to lymphocyte ratio reflects the severity of diseases with an inflammatory component and predicts the risk of developing in-stent restenosis and major adverse cardiac events [ 27 ][ 28 ]. Thus, there is a possibility that the Western diet promotes intimal lesion formation in the ligated carotid artery through action on CD8+ T cells.…”

Section: Discussionmentioning

confidence: 99%

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

et al. 2017

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Complete ligation of the common carotid artery near its bifurcation induces neointimal formation due to smooth muscle cell proliferation in normolipidemic wild-type mice, but it was unknown what would happen to hyperlipidemic apolipoprotein E-deficient (Apoe-/-) mice. Examination of these mice revealed rapid development of atherosclerotic lesions in completely ligated carotid arteries within 4 weeks. Mice were fed a Western diet, starting 1 week before ligation, or a chow diet. Foam cell lesions formed as early as 1 week after ligation in mice fed the Western diet and 2 weeks in mice fed the chow diet. Fibrous lesions comprised of foam cells and smooth muscle cells and more advance lesions containing neovessels occurred at 2 and 4 weeks after ligation, respectively, in the Western diet group. Lesions were larger and more advanced in the Western diet group than the chow group. Neutrophil infiltration was observed in growing intimal lesions in both diet groups, while CD8+ T cells were found in lesions of chow-fed mice. This study demonstrates that Apoe-/- mice develop the entire spectrum of atherosclerosis in ligated carotid arteries in an accelerated manner and this model could be a valuable tool for investigating the development and therapy of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

et al. 2017

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“…Li C et al observed that preprocedural NLR level was a powerful risk factor for early in-stent restenosis in patients who underwent successful PCI for CTO lesions [16]. To our knowledge, only one study showed that NLR △ , de ned as the change of NLR level between on admission and post-PCI, was independently associated with higher risks of in-stent restenosis and MACE in 160 CTO patients at 1-year follow-up [33].…”

Section: Discussionmentioning

confidence: 97%

Impact of Neutrophil-Lymphocyte Ratio on Long-term Outcomes of Patients with Coronary Chronic Total Occlusion After Percutaneous Coronary Intervention

Gao¹,

Li²,

Lei³

et al. 2020

Preprint

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Background: The impact of preprocedural neutrophil-lymphocyte ratio (NLR) level on subsequent adverse cardiovascular events and health status in coronary chronic total occlusion (CTO) patients after stent implantation is unclear. The present study aims to evaluate the impact of NLR level on long-term clinical outcomes and health status of CTO patients after percutaneous coronary intervention (PCI) in the drug eluting stent era.Methods: A total of 311 CTO patients who underwent successful PCI with new-generation drug-eluting stent and with follow-up were enrolled. Patients were classified into 3 groups according to the tertiles of NLR level at baseline. The primary endpoint (major adverse cardiac events, MACE) was a composite of cardiac death, target-vessel myocardial infarction (MI), and ischemia-driven target-vessel revascularization (TVR) on follow-up. Multivariable COX regression analysis was performed to estimate the relationships between the parameters and MACE.Results: Compared with the low and intermediate tertile groups, preprocedural platelet-lymphocyte ratio (PLR) level and age were significantly higher in the high NLR tertile group. After a median follow-up of 32 (interquartile range: 20 to 44) months, MACE was observed in 10 patients (9.7%) in the low tertile, in 21 (20.2%) in the intermediate tertile, and in 31 (29.8%) in the high tertile group (P = 0.001). Kaplan-Meier analysis demonstrated a significantly higher incidence of MACE, mainly driven by TVR, in patients with high tertile than the low and intermediate tertile groups. Multivariable COX regression analysis showed NLR and occluded length as independent predictors of MACE. No statistically differences were observed regarding the five domains of Seattle Angina Questionnaire (SAQ) scores among the 3 groups (all P > 0.05).Conclusions: In conclusion, in patients who underwent PCI for CTO lesions, elevated NLR level was independently associated with MACE (driven by TVR) on follow-up.

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“…Several studies have shown that NLR is elevated and related to poor clinical outcomes of cardiovascular disease in adults, including acute coronary syndrome, atherosclerosis, and heart failure [28][29][30]. However, few studies have looked at NLR levels in children with newly diagnosed hypertension [13,31].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil to Lymphocyte Ratio is Increased and Associated with Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children.

Miao

Cao

Ding

et al. 2020

Preprint

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Aim Hypertension is associated with cardiac structural and functional changes, including left ventricular hypertrophy (LVH), LV systolic dysfunction, and diastolic dysfunction. Neutrophil to lymphocyte ratio (NLR) is a novel inflammatory biomarker associated with cardiovascular diseases. The current study aimed to evaluate NLR in children with newly diagnosed essential hypertension and its relationship between blood pressure and cardiac changes. Methods and subjects 44 children with newly diagnosed essential hypertension and 43 healthy children were included. Clinical characteristics, blood cell counts and biochemical parameters were collected. LVH was assessed by calculation of LV mass index (LVMI), and LV systolic function was evaluated by measuring LV ejection fraction and fractional shortening. LV diastolic function was primarily assessed with E/E’ ratio by doppler and echocardiography. Results The hypertension children had significantly higher LVMI and E/E’ ratio compared to the controls, whereas there was no difference in LV systolic function between two groups. The NLR was significantly higher in the hypertension group than the control group. Moreover, NLR and it was positively correlated with SBP and DBP levels in the hypertension group. Additionally, a significantly positive correlation between NLR and E/E’ ratio was found in the hypertension group. However, NLR was not related to LVH and LV systolic function indicators in hypertension children.Conclusion The higher NLR may be a potential indicator of increased risk for the development of hypertension in children. Moreover, NLR may help to assess the presence of LV diastolic dysfunction in hypertension children.

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Impact of Neutrophil to Lymphocyte Ratio (NLR) Index and Its Periprocedural Change (NLR_Δ) for Percutaneous Coronary Intervention in Patients With Chronic Total Occlusion

Cited by 25 publications

References 45 publications

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

Impact of Neutrophil-Lymphocyte Ratio on Long-term Outcomes of Patients with Coronary Chronic Total Occlusion After Percutaneous Coronary Intervention

Neutrophil to Lymphocyte Ratio is Increased and Associated with Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children.

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Impact of Neutrophil to Lymphocyte Ratio (NLR) Index and Its Periprocedural Change (NLRΔ) for Percutaneous Coronary Intervention in Patients With Chronic Total Occlusion

Cited by 25 publications

References 45 publications

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

Impact of Neutrophil-Lymphocyte Ratio on Long-term Outcomes of Patients with Coronary Chronic Total Occlusion After Percutaneous Coronary Intervention

Neutrophil to Lymphocyte Ratio is Increased and Associated with Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children.

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Impact of Neutrophil to Lymphocyte Ratio (NLR) Index and Its Periprocedural Change (NLR_Δ) for Percutaneous Coronary Intervention in Patients With Chronic Total Occlusion