Impact of Neoadjuvant Chemotherapy (NACT) on Nutritional Status and Treatment-related Morbidity in Medically Unfit Women with Advanced Ovarian Cancer (AOC)

Glaser, Gretchen; Hartman, Leighanne; Cliby, William A.; Torres, Michelle; Tabbaa, Zaid M.; Kalli, Kimberly R.; Weaver, Amy L.; Jatoi, Aminah; Mariani, Andrea

doi:10.1016/j.ygyno.2012.01.026

Cited by 2 publications

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“…The mean serum albumin increased significantly after NAC. Furthermore, pre-and post-NAC computerized tomography assessment revealed improvement in body composition measurements [12]. RC is a morbid operation, commonly followed by ileus (2-32%), infectious (5-39%), and urinary diversion-related (22-33%) complications [13].…”

Section: Introductionmentioning

confidence: 94%

Nutritional Status Impairment Due to Neoadjuvant Chemotherapy Predicts Post-Radical Cystectomy Complications

et al. 2021

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Background: Radical cystectomy (RC) is the standard treatment for muscle invasive bladder cancer (MIBC). Neoadjuvant chemotherapy (NAC) is associated with improved patient survival. The impact of NAC on nutritional status is understudied, while the association between malnutrition and poor surgical outcomes is well known. This study aims to examine the association between NAC, nutritional status impairment, and post-operative morbidity. Materials and Methods: We included MIBC patients who underwent RC and received NAC from multiple academic centers in Israel. Cross-sectional imaging was used to measure the psoas muscle area and normalized it by height (smooth muscle index, SMI). Pre- and post-NAC SMI difference was calculated (represents nutritional status change). The primary outcomes were post-RC ileus, infection, and a composite outcome of any complication. Logistic regression models were fit to identify independent predictors of the outcomes. Results: Ninety-one patients were included in the study. The median SMI change was −0.71 (−1.58, −0.06) cm2/m2. SMI decline was significantly higher in patients with post-RC complications (−18 vs. −203, p < 0.001). SMI change was an independent predictor of all complications, ileus, infection, and other complications. The accuracy of SMI change for predicting all complications, ileus, infection, and other complications was 0.85, 0.87, 0.75, and 0.86, respectively. Conclusions: NAC-related nutritional deterioration is associated with increased risk of complications after RC. Our results hint towards the need for nutritional intervention during NAC prior to RC.

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Section: Introductionmentioning

confidence: 94%