Impact of neoadjuvant chemotherapy (NACT) on nutritional status and treatment-related morbidity in medically unfit women with advanced ovarian cancer (AOC)

Glaser, Gretchen; Hartmann, Lynn C.; Cliby, William A.; Torres, Michelle; Tabbaa, Zaid M.; Kalli, Kimberly R.; Weaver, A. D.; Jatoi, A.; Mariani, Andrea

doi:10.1016/j.ygyno.2011.12.242

Cited by 1 publication

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“…Neoadjuvant chemotherapy offers an alternative approach for patients with nutritional compromise. After two to three cycles of neoadjuvant chemotherapy, the serum albumin level shows improvement, patients start gaining weight, and their performance status improves [37]. This allows the surgeon to exercise maximum surgical efforts during delayed cytoreduction.…”

Section: Nutritional Statusmentioning

confidence: 99%

“…Firstly, patients with platinum-refractory disease will not receive an unnecessary peritoneal surgical debulking with the associated morbidity. Furthermore, neoadjuvant chemotherapy effectively eliminates pleural effusion and ascites, improves performance status and serum albumin level, and, therefore, provides the surgeon with an opportunity to exercise maximum surgical effort with acceptable morbidity [37,46].…”

Section: Stage 4 Diseasementioning

confidence: 99%

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Patient Selection for Ovarian Cancer Debulking Surgery

Balega¹

2018

Ovarian Cancer - From Pathogenesis to Treatment

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Complete surgical cytoreduction is the most important adverse prognostic factor for survival in ovarian cancer. To achieve this, surgeons often have to perform radical and ultraradical procedures with associated significant postoperative morbidity and mortality. Adverse events are most pronounced in patients with borderline or suboptimal capacity to withstand the stress related to surgery. In frail, elderly, malnourished patients, surgeons face limitations to exercise maximum surgical effort; therefore, alternative treatment strategies are required. Neoadjuvant chemotherapy offers a safe and effective way to enhance recovery after delayed debulking surgery in patients who are not optimal candidates for primary debulking surgery.

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Section: Nutritional Statusmentioning

confidence: 99%

Section: Stage 4 Diseasementioning

confidence: 99%