Impact of neoadjuvant chemoradiation on pathologic response and survival of patients with locally advanced rectal cancer

Conde, S.; Borrego, Margarida; Teixeira, Tânia; Teixeira, Rui; Corbal, Maria; Sá, Anabela; Soares, Paula

doi:10.1016/j.rpor.2010.04.002

Cited by 12 publications

(14 citation statements)

References 32 publications

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“…However, ‘overall survival’ was defined in only 20 studies with six different definitions . ‘Disease‐free survival’ was reported in 43 (22.2%) articles and defined in 27 with 16 unique definitions . The most commonly used measures of short‐term operative mortality were ‘30‐day mortality’ and ‘postoperative mortality’, which were reported in 16 (8.2%) and 14 (7.2%) of the included publications, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…A further 13 (19.7%) individual outcomes concerned the time to recurrence, six (9.1%) concerned disease progression and two (3.0%) reported second primary malignancies. The two most frequently reported cancer‐related individual outcomes were ‘local recurrence’ (recorded in 44 studies and defined in 19, in 15 different ways) and ‘distant recurrence’ (recorded in 23 studies and defined in four, in four different ways) .…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of outcome reporting in colorectal cancer surgery

Whistance¹,

Forsythe²,

McNair³

et al. 2013

Colorectal Disease

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Method Systematic literature searches identified randomized and nonrandomized prospective studies reporting clinical outcomes of CRC surgery. Outcomes were listed verbatim, categorized into broad groups (outcome domains) and examined for a definition (an appropriate textual explanation or a supporting citation). Outcome reporting was considered inconsistent if results of the outcome specified in the methods were not reported. Outcome reporting was compared between randomized and nonrandomized studies.Results Of 5644 abstracts, 194 articles (34 randomized and 160 nonrandomized studies) were included reporting 766 different clinical outcomes, categorized into seven domains. A mean of 14 AE 8 individual outcomes were reported per study. 'Anastomotic leak', 'overall survival' and 'wound infection' were the three most frequently reported outcomes in 72, 60 and 44 (37.1%, 30.9% and 22.7%) studies, respectively, and no single outcome was reported in every publication. Outcome definitions were significantly more often provided in randomized studies than in nonrandomized studies (19.0% vs 14.9%, P = 0.015). One-hundred and twenty-seven (65.5%) papers reported results of all outcomes specified in the methods (randomized studies, n = 21, 61.5%; nonrandomized studies, n = 106, 66.2%; P = 0.617).Conclusion Outcome reporting in CRC surgery lacks consistency and method. Improved standards of outcome measurement are recommended to permit data synthesis and transparent cross-study comparisons.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A systematic review of outcome reporting in colorectal cancer surgery

Whistance¹,

Forsythe²,

McNair³

et al. 2013

Colorectal Disease

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“…When considering treatment options for rectal cancer, preoperative evaluations are important, because decisions regarding surgery and preoperative concurrent chemoradiotherapy are dependent on tumour location, mesorectal fascia involvement, and nodal status 6,7,9–13. Rectal MRI is commonly performed preoperatively for evaluating the mesorectal fascia or adjacent organ involvement, and nodal staging 6–9.…”

Section: Discussionmentioning

confidence: 99%

Is rectal MRI beneficial for determining the location of rectal cancer with respect to the peritoneal reflection?

Jung¹,

Ryu²,

Kim³

et al. 2012

Radiology and Oncology

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BackgroundAn objective method for determining the location of the cancer with respect to peritoneal reflection would be helpful to decide the treatment modality for rectal cancer. This study was designed to evaluate the accuracy and usefulness of rectal MRI to determine spatial relations between the peritoneal reflection and rectal cancer and to compare these with operative findings.Patients and methodsPatients that underwent a rectal cancer operation after a rectal MRI check between November 2008 and June 2010 were considered for the study. The patients that received preoperative concurrent chemoradiation or trans-anal local excision were excluded.ResultsFifty-four patients constituted the study cohort. By comparing surgical and radiologic findings, the accuracy for predicting tumour location in relation to the peritoneal reflection by rectal MRI in all patients was 90.7%. In terms of tumour location in relation to peritoneal reflection, the accuracy of rectal MRI was 93.5% in patients with a tumour located above the peritoneal reflection, 90.0% in patients with a tumour located on the peritoneal reflection, and 84.6% in patients with a tumour located below the peritoneal reflection (p=0.061). When the cohort was subdivided by gender, body mass index (BMI), operative findings, or tumour size, no significant difference was observed among subgroups.ConclusionsRectal MRI could be a useful tool for evaluating the relation between rectal cancer and peritoneal reflection especially when tumour size is less than 8cm. Rectal MRI can provide information regarding the location of rectal cancer in relation to the peritoneal reflection for treatment planning purposes.

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“…When considering only those patients cT3-4 who had downstaging to ypT0-2, we found a significantly better locoregional control (100% vs 89, p = 0.027), PFS (88% vs 43%, p = 0.003) and OS (89% vs 77%, p = 0.048). Adjuvant chemotherapy had no impact on locoregional control, PFS or on OS (Conde, 2010).…”

Section: Prognostic Factors For Responders To Chemoradiationmentioning

confidence: 86%