Impact of Naples Prognostic Score on Midterm All-Cause Mortality in Patients with Decompensated Heart Failure

Abstract

Aim: This work was designed to investigate the relationship between cardiac outcomes and Naples Prognostic Score (NPS) among heart failure (HF) patients. Materials & methods: This retrospective observational study enrolled 298 consecutive individuals hospitalized for New York Heart Association class 3–4 HF. The primary outcome was all-cause mortality. Secondary outcomes were rehospitalization and in-hospital death. Results: The high NPS group had a statistically greater rate of all-cause mortality (p < 0.001). In Cox regression analysis, integrating NPS considerably improved the performance of the full model over the baseline model (adjusted hazard ratio = 2.28; p = 0.004). Based on time-dependent receiver operating characteristic curve analysis, the NPS model outperformed the baseline and CONUT score models in discriminatory power in predicting the probability of survival. Conclusion: NPS was associated with short- and midterm mortality as well as rehospitalization.

Clinical implication of the Naples prognostic score on transcatheter aortic valve replacement in patients with severe aortic stenosis

“…They also reported that only the NPS was an independent predictor of overall (HR = 2.0; p = 0.03) and disease‐free survival rates (HR = 2.6; p = 0.01) 8 . Moreover, several data for the prognostic significance of the NPS in cardiovascular diseases such as acute coronary syndrome and heart failure has recently been introduced to the literature 10,18,20 . Beyond the prognostic significance of the NPS, Birdal et al 25 have recently described a relationship between the NPS and the low left ventricular ejection fraction in patients with ST‐elevation myocardial infarction.…”

“…Initially, several scores were developed related to malnutrition, which was associated with poor clinical outcomes in cancer patients 8,15,16 . Additionally, malnutrition has also been associated with mortality, morbidity, and disease severity in cardiovascular disease 6,10,13,14,17–21 . Recently, several investigators have reported that malnutrition is a predictor of worse outcomes in patients with severe AS undergoing surgical aortic valve replacement 14,22 .…”

“…8,15,16 Additionally, malnutrition has also been associated with mortality, morbidity, and disease severity in cardiovascular disease. 6,10,13,14,[17][18][19][20][21] Recently, several investigators have reported that malnutrition is a predictor of worse outcomes in patients with severe AS undergoing surgical aortic valve replacement. 14,22 Likewise, Sudo et al have recently shown that patients with low nutritional status were more likely to have right-sided heart overload and exhibited an increased risk of 3-year mortality.…”

“…8 diseases such as acute coronary syndrome and heart failure has recently been introduced to the literature. 10,18,20 Beyond the prognostic significance of the NPS, Birdal et al 25 have recently described a relationship between the NPS and the low left ventricular ejection fraction in patients with ST-elevation myocardial infarction.…”